(6-AMINO-3-PYRIDINYL)METHANOL
- Product Name
- (6-AMINO-3-PYRIDINYL)METHANOL
- CAS No.
- 113293-71-3
- Chemical Name
- (6-AMINO-3-PYRIDINYL)METHANOL
- Synonyms
- 2-Amino-5-hydroxymethyL;Abemaciclib Impurity 33;2-Amino-5-pyridinemethanol;2-AMinopyridine-5-Methanol;(6-aminopyridin-3-yl)metha;(6-Amino-3-pyridyl)methanol;2-Amino-5-hydroxymethylpy...;3-Pyridinemethanol, 6-amino-;(6-AMINO-3-PYRIDINYL)METHANOL;2-Aminopyridine-5-methanol,97%
- CBNumber
- CB0176628
- Molecular Formula
- C6H8N2O
- Formula Weight
- 124.14
- MOL File
- 113293-71-3.mol
(6-AMINO-3-PYRIDINYL)METHANOL Property
- Melting point:
- 120 °C
- Boiling point:
- 320.2±27.0 °C(Predicted)
- Density
- 1.257±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- powder to crystal
- pka
- 13.61±0.10(Predicted)
- color
- White to Light yellow to Light orange
- Water Solubility
- Sparingly soluble in water.(0.26 g/L) (25°C),
- InChI
- InChI=1S/C6H8N2O/c7-6-2-1-5(4-9)3-8-6/h1-3,9H,4H2,(H2,7,8)
- InChIKey
- TXPRFSOGPYITOT-UHFFFAOYSA-N
- SMILES
- C1=NC(N)=CC=C1CO
- CAS DataBase Reference
- 113293-71-3
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 22-36/37/38-20/21/22
- Safety Statements
- 22-26-36/37/39
- RIDADR
- 2811
- Hazard Note
- Irritant
- HS Code
- 29221990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- MNO000168
- Product name
- 2-Amino-5-pyridinemethanol
- Packaging
- 1g
- Price
- $179
- Updated
- 2025/07/31
- Product number
- A3148
- Product name
- 2-Amino-5-pyridinemethanol
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $113
- Updated
- 2025/07/31
- Product number
- A615648
- Product name
- (6-Aminopyridin-3-yl)methanol
- Packaging
- 500mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- 4H56-1-VG
- Product name
- 2-Amino-5-(hydroxymethyl)pyridine
- Purity
- 97%
- Packaging
- 1g
- Price
- $84
- Updated
- 2021/12/16
- Product number
- OR14503
- Product name
- 2-Amino-5-(hydroxymethyl)pyridine
- Purity
- 97%
- Packaging
- 250mg
- Price
- $24
- Updated
- 2021/12/16
(6-AMINO-3-PYRIDINYL)METHANOL Chemical Properties,Usage,Production
Chemical Properties
White to light yellow solid
Uses
It is used as pharmaceutical intermediate. Benzoylthiophenes are allosteric enhancers (AE) of agonist activity at the A1 adenosine receptor.
Synthesis
3167-49-5
113293-71-3
1. Concentrated sulfuric acid (0.95 mL, 17.2 mmol, 0.5 eq.) was slowly added to a solution of 6-aminonicotinic acid (5.0 g, 34.4 mmol) in ethanol (50 mL). 2. The reaction mixture was heated and refluxed for 16 h. 3. Upon completion of the reaction the mixture was carefully poured into a concentrated aqueous solution of Na2CO3 to neutralize. 4. The aqueous phases were extracted three times using EtOAc. 5. The organic layers were combined, washed with saturated brine, dried over anhydrous Na2SO4, filtered, and concentrated under reduced pressure.6 The concentrated residue was dissolved in anhydrous THF (25 mL).7 Lithium aluminium hydride (2.68 g, 68.6 mmol, 3.0 eq.) was added slowly at -60 °C.8 The reaction mixture was gradually warmed to 0 °C, followed by refluxing for 1 h. The reaction was completed by cooling to room temperature and then refluxing for 1 h. The reaction was completed by cooling to room temperature. At the end of the reaction, the reaction was cooled to room temperature and quenched by the addition of water (1.5 mL) and 5N aqueous NaOH (1.5 mL). 10. The precipitate was removed by filtration, and the filtrate was concentrated under reduced pressure. 11. The residue was purified by fast column chromatography (eluent: EtOAc/MeOH 95:5) to afford the target product, 6-amino-3-pyridinemethanol (2.15 g, 72% yield). 12. The structure of the product was determined by 1.5 mL of fast column chromatography (eluent: EtOAc/MeOH 95:5). The product structure was confirmed by 1H NMR and mass spectrometry: 1H NMR (400 MHz, d6-DMSO): δ= 7.82 (d, J = 1.7 Hz, 1H), 7.32 (dd, J = 8.3/2.5 Hz, 1H), 6.40 (dd, J = 9.3/1.0 Hz, 1H), 5.77 (br s, 2H), 4.88 ( t, J = 5.5 Hz), 4.88 (br s, 2H), 4.88 (t, J = 5.5 Hz, 4.88), 4.88 ( t, J = 5.5 Hz, 1H), 4.27 (d, J = 5.5 Hz, 2H). MS (ES+): 125 (M + H)+.
References
[1] Patent: WO2008/74752, 2008, A2. Location in patent: Page/Page column 27-28
[2] Patent: EP1798221, 2007, A1. Location in patent: Page/Page column 32
[3] Patent: EP1956013, 2008, A1. Location in patent: Page/Page column 30-31
[4] Patent: US2007/99930, 2007, A1. Location in patent: Page/Page column 42
[5] Patent: WO2013/13817, 2013, A1
(6-AMINO-3-PYRIDINYL)METHANOL Preparation Products And Raw materials
Raw materials
Preparation Products
(6-AMINO-3-PYRIDINYL)METHANOL Suppliers
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
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- Americas
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View Lastest Price from (6-AMINO-3-PYRIDINYL)METHANOL manufacturers
- Product
- (6-AMINO-3-PYRIDINYL)METHANOL 113293-71-3
- Price
- US $10.00-95.00/KG
- Min. Order
- 1KG
- Purity
- 0.98
- Supply Ability
- 20 tons
- Release date
- 2023-09-28
- Product
- (6-Amino-3-pyridinyl)methanol 113293-71-3
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-01-02
- Product
- (6-Amino-pyridin-3-yl)methanol 113293-71-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1g
- Purity
- 98%min
- Supply Ability
- 100kgs/month
- Release date
- 2021-11-27