ChemicalBook > CAS DataBase List > (6-AMINO-3-PYRIDINYL)METHANOL

(6-AMINO-3-PYRIDINYL)METHANOL

Product Name: (6-AMINO-3-PYRIDINYL)METHANOL
CAS No.: 113293-71-3
Chemical Name: (6-AMINO-3-PYRIDINYL)METHANOL
Synonyms: 2-Amino-5-hydroxymethyL;Abemaciclib Impurity 33;2-Amino-5-pyridinemethanol;2-AMinopyridine-5-Methanol;(6-aminopyridin-3-yl)metha;(6-Amino-3-pyridyl)methanol;2-Amino-5-hydroxymethylpy...;3-Pyridinemethanol, 6-amino-;(6-AMINO-3-PYRIDINYL)METHANOL;2-Aminopyridine-5-methanol,97%
CBNumber: CB0176628
Molecular Formula: C6H8N2O
Formula Weight: 124.14
MOL File: 113293-71-3.mol

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(6-AMINO-3-PYRIDINYL)METHANOL Property

Melting point:: 120 °C
Boiling point:: 320.2±27.0 °C(Predicted)
Density: 1.257±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
form: powder to crystal
pka: 13.61±0.10(Predicted)
color: White to Light yellow to Light orange
Water Solubility: Sparingly soluble in water.(0.26 g/L) (25°C),
InChI: InChI=1S/C6H8N2O/c7-6-2-1-5(4-9)3-8-6/h1-3,9H,4H2,(H2,7,8)
InChIKey: TXPRFSOGPYITOT-UHFFFAOYSA-N
SMILES: C1=NC(N)=CC=C1CO
CAS DataBase Reference: 113293-71-3

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22-36/37/38-20/21/22
Safety Statements: 22-26-36/37/39
RIDADR: 2811
Hazard Note: Irritant
HS Code: 29221990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: MNO000168
Product name: 2-Amino-5-pyridinemethanol
Packaging: 1g
Price: $179
Updated: 2025/07/31

TCI Chemical

Product number: A3148
Product name: 2-Amino-5-pyridinemethanol
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $113
Updated: 2025/07/31

TRC

Product number: A615648
Product name: (6-Aminopyridin-3-yl)methanol
Packaging: 500mg
Price: $130
Updated: 2021/12/16

Apolloscientific

Product number: OR14503
Product name: 2-Amino-5-(hydroxymethyl)pyridine
Purity: 97%
Packaging: 250mg
Price: $24
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-1-VG
Product name: 2-Amino-5-(hydroxymethyl)pyridine
Purity: 97%
Packaging: 250mg
Price: $32
Updated: 2021/12/16

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(6-AMINO-3-PYRIDINYL)METHANOL Chemical Properties,Usage,Production

Chemical Properties

White to light yellow solid

Uses

It is used as pharmaceutical intermediate. Benzoylthiophenes are allosteric enhancers (AE) of agonist activity at the A1 adenosine receptor.

Synthesis

3167-49-5

113293-71-3

1. Concentrated sulfuric acid (0.95 mL, 17.2 mmol, 0.5 eq.) was slowly added to a solution of 6-aminonicotinic acid (5.0 g, 34.4 mmol) in ethanol (50 mL). 2. The reaction mixture was heated and refluxed for 16 h. 3. Upon completion of the reaction the mixture was carefully poured into a concentrated aqueous solution of Na2CO3 to neutralize. 4. The aqueous phases were extracted three times using EtOAc. 5. The organic layers were combined, washed with saturated brine, dried over anhydrous Na2SO4, filtered, and concentrated under reduced pressure.6 The concentrated residue was dissolved in anhydrous THF (25 mL).7 Lithium aluminium hydride (2.68 g, 68.6 mmol, 3.0 eq.) was added slowly at -60 °C.8 The reaction mixture was gradually warmed to 0 °C, followed by refluxing for 1 h. The reaction was completed by cooling to room temperature and then refluxing for 1 h. The reaction was completed by cooling to room temperature. At the end of the reaction, the reaction was cooled to room temperature and quenched by the addition of water (1.5 mL) and 5N aqueous NaOH (1.5 mL). 10. The precipitate was removed by filtration, and the filtrate was concentrated under reduced pressure. 11. The residue was purified by fast column chromatography (eluent: EtOAc/MeOH 95:5) to afford the target product, 6-amino-3-pyridinemethanol (2.15 g, 72% yield). 12. The structure of the product was determined by 1.5 mL of fast column chromatography (eluent: EtOAc/MeOH 95:5). The product structure was confirmed by 1H NMR and mass spectrometry: 1H NMR (400 MHz, d6-DMSO): δ= 7.82 (d, J = 1.7 Hz, 1H), 7.32 (dd, J = 8.3/2.5 Hz, 1H), 6.40 (dd, J = 9.3/1.0 Hz, 1H), 5.77 (br s, 2H), 4.88 ( t, J = 5.5 Hz), 4.88 (br s, 2H), 4.88 (t, J = 5.5 Hz, 4.88), 4.88 ( t, J = 5.5 Hz, 1H), 4.27 (d, J = 5.5 Hz, 2H). MS (ES+): 125 (M + H)+.

References

[1] Patent: WO2008/74752, 2008, A2. Location in patent: Page/Page column 27-28
[2] Patent: EP1798221, 2007, A1. Location in patent: Page/Page column 32
[3] Patent: EP1956013, 2008, A1. Location in patent: Page/Page column 30-31
[4] Patent: US2007/99930, 2007, A1. Location in patent: Page/Page column 42
[5] Patent: WO2013/13817, 2013, A1

(6-AMINO-3-PYRIDINYL)METHANOL Preparation Products And Raw materials

Raw materials

2-Amino-5-methylpyridine Ammonium hydroxide Ethanol Acetic anhydride Tetrahydrofuran Benzene Sulfuryl chloride Lithium Aluminum Hydride Hydrochloric acid Potassium permanganate Sodium hydroxide Thionyl chloride

Preparation Products

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(6-AMINO-3-PYRIDINYL)METHANOL Suppliers

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View Lastest Price from (6-AMINO-3-PYRIDINYL)METHANOL manufacturers

Zibo Hangyu Biotechnology Development Co., Ltd

Product: (6-AMINO-3-PYRIDINYL)METHANOL 113293-71-3
Price: US $10.00-95.00/KG
Min. Order: 1KG
Purity: 0.98
Supply Ability: 20 tons
Release date: 2023-09-28

Henan Fengda Chemical Co., Ltd

Product: (6-Amino-3-pyridinyl)methanol 113293-71-3
Price: US $200.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-01-02

Shanghai Rlavie Technology Co ltd

Product: (6-Amino-pyridin-3-yl)methanol 113293-71-3
Price: US $0.00-0.00/KG
Min. Order: 1g
Purity: 98%min
Supply Ability: 100kgs/month
Release date: 2021-11-27

113293-71-3, (6-AMINO-3-PYRIDINYL)METHANOLRelated Search:

6-(1H-Pyrazol-1-yl)nicotinic acid 2-ACETAMIDO-5-PYRIDINECARBOXYLIC ACID 6-Aminonicotinic acid Methyl 6-(1H-pyrazol-1-yl)pyridine-3-carboxylate (2-AMINO-3-PYRIDINYL)METHANOL 3-Pyridinemethanol METHYL 6-(1H-IMIDAZOL-1-YL)NICOTINATE 6-(1H-Pyrrol-1-yl)pyridine-3-carboxylic acid 6-(1H-IMIDAZOL-1-YL)NICOTINIC ACID DIETHYL 2-HYDROXY-6-(2-PHENYLHYDRAZINO)-3,5-PYRIDINEDICARBOXYLATE DIETHYL 2-AMINO-6-(2-ISONICOTINOYLHYDRAZINO)-3,5-PYRIDINEDICARBOXYLATE 7-(dimethylamino)-4-methoxy-1-methyl-1,8-naphthyridin-2(1H)-one DIETHYL 2-(3,5-DIMETHYL-1H-PYRAZOL-1-YL)-6-HYDROXY-3,5-PYRIDINEDICARBOXYLATE DIETHYL 2-(2-[1-(6-FLUORO-2-PYRIDINYL)-4-PIPERIDINYLIDENE]HYDRAZINO)-6-HYDROXY-3,5-PYRIDINEDICARBOXYLATE DIETHYL 2-HYDROXY-6-[2-(1-METHYL-4-PIPERIDINYLIDENE)HYDRAZINO]-3,5-PYRIDINEDICARBOXYLATE DIETHYL 2-HYDROXY-6-(2-[1-(4-NITROPHENYL)-4-PIPERIDINYLIDENE]HYDRAZINO)-3,5-PYRIDINEDICARBOXYLATE 2-AMINO-7,7-DIMETHYL-7,8-DIHYDRO-5H-PYRANO[4,3-B]PYRIDINE-3-CARBOXYLIC ACID DIETHYL 2-(2-(1-[2,6-DINITRO-4-(TRIFLUOROMETHYL)PHENYL]-4-PIPERIDINYLIDENE)HYDRAZINO)-6-HYDROXY-3,5-PYRIDINEDICARBOXYLATE

2-Amino-5-(hydroxymethyl)pyridine

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2-AMINO-5-PYRIDINEMETHANOL(2-AMINO-5-HYDROXYMETHYLPYRIDINE)

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2-Amino-5-hydroxymethylpy...

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(6-AMINO-3-PYRIDINYL)METHANOL ISO 9001：2015 REACH

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(6-aminopyridin-3-yl)metha

Abemaciclib Impurity 33

113293-71-3

Furans

PYRIDINE

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