Methyl 6-(1H-pyrazol-1-yl)pyridine-3-carboxylate
- Product Name
- Methyl 6-(1H-pyrazol-1-yl)pyridine-3-carboxylate
- CAS No.
- 321533-62-4
- Chemical Name
- Methyl 6-(1H-pyrazol-1-yl)pyridine-3-carboxylate
- Synonyms
- METHYL 6-(1H-PYRAZOL-1-YL)NICOTINATE;6-PYRAZOL-1-YL-NICOTINIC ACID METHYL ESTER;methyl 6-pyrazol-1-ylpyridine-3-carboxylate;6-Pyrazol-1-yl-nicotinic acid methyl ester ,97%;METHYL 6-(1H-PYRAZOL-1-YL)PYRIDINE-3-CARBOXYLATE;Methyl 6-(1H-pyrazol-1-yl)-3-pyridinecarboxylate;6-(1-pyrazolyl)-3-pyridinecarboxylic acid methyl ester;3-Pyridinecarboxylic acid, 6-(1H-pyrazol-1-yl)-, methyl ester
- CBNumber
- CB6349185
- Molecular Formula
- C10H9N3O2
- Formula Weight
- 203.2
- MOL File
- 321533-62-4.mol
Methyl 6-(1H-pyrazol-1-yl)pyridine-3-carboxylate Property
- Boiling point:
- 330.8±27.0 °C(Predicted)
- Density
- 1.27±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- -0.42±0.19(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M593163
- Product name
- Methyl6-(1H-pyrazol-1-yl)nicotinate
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- JK244528
- Product name
- 6-Pyrazol-1-yl-nicotinicacidmethylester
- Purity
- 97%
- Packaging
- 1g
- Price
- $180
- Updated
- 2021/12/16
- Product number
- 138460
- Product name
- Methyl 6-(1H-pyrazol-1-yl)nicotinate
- Purity
- 95%+
- Packaging
- 1g
- Price
- $182
- Updated
- 2021/12/16
- Product number
- 138460
- Product name
- Methyl 6-(1H-pyrazol-1-yl)nicotinate
- Purity
- 95%+
- Packaging
- 2.500g
- Price
- $393
- Updated
- 2021/12/16
- Product number
- Z3008
- Product name
- 6-(1H-Pyrazol-1-yl)nicotinicacidmethylester
- Packaging
- 10g
- Price
- $481
- Updated
- 2021/12/16
Methyl 6-(1H-pyrazol-1-yl)pyridine-3-carboxylate Chemical Properties,Usage,Production
Chemical Properties
Off-white solid
Synthesis
288-13-1
73781-91-6
321533-62-4
Example 7. Preparation of 0-(6-pyrazol-1-yl-pyridin-3-ylmethyl)-hydroxylamine (compound of Formula (XI)); Step 7a. Preparation of methyl 6-pyrazol-1-yl-nicotinate (compound of Formula (XI-a)); To a solution of pyrazole (19.4 g, 0.28 mol) dissolved in 100 mL of anhydrous DMSO (at temperature 0°C) was added, in one portion, over 30 minutes, a solution of pyrazole (19.4 g, 0.28 mol) dissolved in NaH (7.5 g, 0.3 mol). The reaction mixture was slowly warmed up to room temperature and stirred continuously at that temperature for 30 min. Subsequently, methyl 6-chloronicotinate (35 g, 0.2 mol) was added to the stirring reaction mixture and stirred vigorously for 6 hours. Upon completion of the reaction, the mixture was cooled to about 0 °C and slowly poured into pre-cooled saturated aqueous NH4Cl solution. The precipitate formed was collected by filtration, washed with water and dried to give the compound of formula (XI-a) (38.3 g, 93% yield) as an off-white solid.
References
[1] Patent: WO2005/70918, 2005, A1. Location in patent: Page/Page column 40
[2] Patent: US2008/153812, 2008, A1. Location in patent: Page/Page column 102
Methyl 6-(1H-pyrazol-1-yl)pyridine-3-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl 6-(1H-pyrazol-1-yl)pyridine-3-carboxylate manufacturers
- Product
- Methyl 6-(1H-pyrazol-1-yl)pyridine-3-carboxylate 321533-62-4
- Price
- US $2.00/KG
- Min. Order
- 1g
- Purity
- 98%min
- Supply Ability
- ask
- Release date
- 2020-01-08