(2-Aminopyridin-3-yl)methanol
- Product Name
- (2-Aminopyridin-3-yl)methanol
- CAS No.
- 23612-57-9
- Chemical Name
- (2-Aminopyridin-3-yl)methanol
- Synonyms
- (2-AMINO-PYRIDIN-3-YL)-METHANOL;RARECHEM AL BD 1234;(2-Aminopyridin-3-yL;2-(Aminopyridine-3-yl);2-Amino-3-Hydroxymethyl;2-Amino-3-pyridylmethanol;2-Amino-3-pyridinemethanol;2-AMINOPYRIDINE-3-METHANOL;3-Pyridinemethanol, 2-amino-;(2-AMINO-3-PYRIDINYL)METHANOL
- CBNumber
- CB2276999
- Molecular Formula
- C6H8N2O
- Formula Weight
- 124.14
- MOL File
- 23612-57-9.mol
(2-Aminopyridin-3-yl)methanol Property
- Melting point:
- 66-68°C
- Boiling point:
- 320.7±27.0 °C(Predicted)
- Density
- 1.257±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- soluble in Methanol
- form
- Powder
- pka
- 13.54±0.10(Predicted)
- color
- Pale-Yellow
- Sensitive
- Air Sensitive
- CAS DataBase Reference
- 23612-57-9(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-22
- Safety Statements
- 26-36-37
- WGK Germany
- 3
- Hazard Note
- Irritant
- HazardClass
- 6.1
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H301Toxic if swalloed
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- ADE000265
- Product name
- (2-Amino-pyridin-3-yl)-methanol
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $216
- Updated
- 2025/07/31
- Product number
- A2358
- Product name
- 2-Amino-3-pyridinemethanol
- Purity
- >96.0%(GC)
- Packaging
- 1g
- Price
- $49
- Updated
- 2025/07/31
- Product number
- A2358
- Product name
- 2-Amino-3-pyridinemethanol
- Purity
- >96.0%(GC)
- Packaging
- 5g
- Price
- $167
- Updated
- 2025/07/31
- Product number
- A628995
- Product name
- (2-Aminopyridin-3-yl)methanol
- Packaging
- 25g
- Price
- $1540
- Updated
- 2021/12/16
- Product number
- FA17841
- Product name
- (2-Aminopyridin-3-yl)methanol
- Packaging
- 25g
- Price
- $1911
- Updated
- 2021/12/16
(2-Aminopyridin-3-yl)methanol Chemical Properties,Usage,Production
Chemical Properties
Light yellow Cryst
Uses
(2-Aminopyridin-3-yl)methanol is an intermediate used in the synthesis of mirtazapine, an antidepressant.
Synthesis
13362-26-0
23612-57-9
In a three-necked flask, 5 g of ethyl 2-aminonicotinate (0.0302 mol) and 80 mL of tetrahydrofuran were added, and 13 g of sodium borohydride (0.2416 mol) powder was slowly added under stirring. The reaction mixture was stirred at 65 °C for 15 min before 65 mL of methanol was added dropwise, followed by heating and refluxing the reaction. The reaction process was monitored by thin layer chromatography (TLC, unfolding agent ratio of trichloromethane: methanol = 4:1). Upon completion of the reaction, vacuum concentration was performed while hot. To the concentrate, 40 mL of the mixture and 1 g of sodium hydroxide were added and hydrolyzed at 70-80 °C for 7-8 hours. After completion of the reaction, the organic phase was separated and dried with anhydrous sodium sulfate and subsequently concentrated to give Intermediate A (2-amino-3-pyridinecarboxylic acid ethanol) as a light yellow solid powder 2.7 g in 75% yield with a melting point of 67.5-68 °C.
References
[1] Patent: CN104892608, 2017, B. Location in patent: Paragraph 0040; 0041; 0047; 0048
[2] Polish Journal of Chemistry, 2003, vol. 77, # 5, p. 535 - 545
[3] Patent: US2005/20587, 2005, A1. Location in patent: Page 17
(2-Aminopyridin-3-yl)methanol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (2-Aminopyridin-3-yl)methanol manufacturers
- Product
- 2-Aminopyridine-3-methanol 23612-57-9
- Price
- US $1.10-9.90/KG
- Min. Order
- 1KG
- Purity
- 99%min
- Supply Ability
- 100KG
- Release date
- 2025-08-20
- Product
- (2-Aminopyridin-3-yl)methanol 23612-57-9
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-25
- Product
- (2-Aminopyridin-3-yl)methanol 23612-57-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27