Methyl 2-aminonicotinate

Product Name: Methyl 2-aminonicotinate
CAS No.: 14667-47-1
Chemical Name: Methyl 2-aminonicotinate
Synonyms: RARECHEM AL BF 1234;Methyl 2-aminonicoti;Methyl 2-aminonicotite;METHYL 2-AMINONICOTINATE;2- aMinoMethyl nicotinate;Methyl2-Aminonicotinate>Methyl2-aminonicotinate,97%;Methyl 2-aMinonicotinate, >95%;2-AMINO-NICOTINIC ACID METHYL ESTER;Methyl 2-aminopyridin-3-carboxylate
CBNumber: CB6279529
Molecular Formula: C7H8N2O2
Formula Weight: 152.15
MOL File: 14667-47-1.mol

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Methyl 2-aminonicotinate Property

Melting point:: 82-86 °C
Boiling point:: 251.3±20.0 °C(Predicted)
Density: 1.238±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: soluble in Methanol
form: powder to crystal
pka: 4.71±0.36(Predicted)
color: White to Almost white
InChI: InChI=1S/C7H8N2O2/c1-11-7(10)5-3-2-4-9-6(5)8/h2-4H,1H3,(H2,8,9)
InChIKey: NZZDEODTCXHCRS-UHFFFAOYSA-N
SMILES: C1(N)=NC=CC=C1C(OC)=O
CAS DataBase Reference: 14667-47-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22-36/37/38
Safety Statements: 22-26-36/37/39
WGK Germany: 2
HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 715107
Product name: Methyl 2-aminopyridine-3-carboxylate
Purity: 97%
Packaging: 5g
Price: $161
Updated: 2025/07/31

Sigma-Aldrich

Product number: 715107
Product name: Methyl 2-aminopyridine-3-carboxylate
Purity: 97%
Packaging: 1g
Price: $81
Updated: 2023/06/20

TCI Chemical

Product number: M2125
Product name: Methyl 2-Aminonicotinate
Purity: >97.0%(GC)(T)
Packaging: 1g
Price: $29
Updated: 2025/07/31

TCI Chemical

Product number: M2125
Product name: Methyl 2-Aminonicotinate
Purity: >97.0%(GC)(T)
Packaging: 5g
Price: $78
Updated: 2025/07/31

TRC

Product number: M286995
Product name: Methyl 2-Aminonicotinate
Packaging: 1g
Price: $70
Updated: 2021/12/16

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Methyl 2-aminonicotinate Chemical Properties,Usage,Production

Chemical Properties

Off white powder

Uses

Methyl 2-Aminonicotinate is used to prepare 2-{4-[(3S)-Piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827)as a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors. It is also used to synthesize quinazolinone/quinazoline thione derivatives as phosphodiesterase 7 inhibitors.

Synthesis

67-56-1

5345-47-1

14667-47-1

Concentrated sulfuric acid (96%, 144 mL, 2.69 mol, 18.6 eq.) was slowly added dropwise to a stirred suspension of 2-aminonicotinic acid (20.0 g, 0.145 mol) in methanol (228 mL, 7.12 mol, 49.2 eq.), and the reaction system was kept at 0 °C. Subsequently, the reaction mixture was irradiated in a microwave reactor (power input 300 W) at 60 °C and atmospheric pressure for 1.5 hours. Upon completion of the reaction, the light brown mixture was carefully poured into ice water, maintained at 0 °C, and solid sodium carbonate was added by batchwise addition until complete neutralization (pH > 8). The aqueous layer was extracted three times with ethyl acetate. The organic layers were combined, washed sequentially with saturated brine and deionized water, and then dried with anhydrous magnesium sulfate. Finally, the organic solvent was evaporated to afford methyl 2-aminopyridine-3-carboxylate (21.15 g, 93% yield) as colorless needle-like crystals with purity meeting the analytical requirements.

References

[1] Tetrahedron, 2014, vol. 70, # 35, p. 5541 - 5549
[2] European Journal of Medicinal Chemistry, 2012, vol. 52, p. 284 - 294
[3] Synthetic Communications, 2006, vol. 36, # 2, p. 181 - 186
[4] Patent: WO2005/32481, 2005, A2. Location in patent: Page/Page column 38
[5] Patent: WO2005/32481, 2005, A2. Location in patent: Page/Page column 38

Methyl 2-aminonicotinate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl 2-aminonicotinate Suppliers

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View Lastest Price from Methyl 2-aminonicotinate manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Methyl 2-aminonicotinate 14667-47-1
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-04-30

Henan Aochuang Chemical Co.,Ltd.

Product: Methyl 2-aminonicotinate 14667-47-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-10-09

Shaanxi Haibo Biotechnology Co., Ltd

Product: Methyl 2-aminonicotinate 14667-47-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000ton
Release date: 2023-08-31

14667-47-1, Methyl 2-aminonicotinateRelated Search:

Methyl 2-aminonicotinate Morniflumate Talniflumate METHYL 2-AMINOPYRIDINE-4-CARBOXYLATE 2-Pyridinecarboxylicacid,5-amino-,methylester(9CI) METHYL 3-AMINOPYRIDINE-4-CARBOXYLATE Methyl 6-aminopyridine-2-carboxylate,Methyl 6-aminopyridine-2-carboxylate 98% Methyl 5-aminopyridine-3-carboxylate ,98%,METHYL 5-AMINONICOTINATE Methyl 6-aminonicotinate METHYL-4-AMINONICOTINATE,methyl 4-aminopyridine-3-carboxylate methyl 3-aminopyridine-2-carboxylate Methyl 4-aminopyridine-2-carboxylate 2-Aminonicotinic acid Methyl nicotinate 2-AMINO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER Clonixeril Methyl 2-(dimethylamino)pyridine-4-carboxylate ,97% ISOPROPYL 2-(4-PHENYLPIPERAZINO)NICOTINATE

Methyl 2-aminonicoti

2- aMinoMethyl nicotinate

2-aMinopyridine-3- forMic acidMethyl ester

Methyl 2-amino-3-pyridinecarboxylate

2-Aminonicotinic Acid Methyl Ester Methyl 2-Aminopyridine-3-carboxylate 2-Aminopyridine-3-carboxylic Acid Methyl Ester

Methyl 2-aMinonicotinate, >95%

Methyl2-aminonicotinate,97%

Methyl 2-aminonicotite

METHYL 2-AMINONICOTINATE

RARECHEM AL BF 1234

Methyl 2-aminopyridine-3-carboxylate

2-Amino-3-pyridinecarboxylic acid methyl ester

2-Aminopyridine-3-carboxylic acid methyl ester

3-Pyridinecarboxylic acid, 2-amino-, methyl ester

2-AMINO-NICOTINIC ACID METHYL ESTER

2-METHYL-4-(TRIFLUOROMETHYL)-5-AMINOTHIAZOLE

Methyl2-Aminonicotinate&gt

Methyl 2-aminonicotinate ISO 9001：2015 REACH

3-Pyridinecarboxylic acid, 2-amino-, methyl ester (9CI, ACI)

2-amino-3-Pyridinecarboxylic acid methyl ester (9CI ACI)

2-Aminopyridin-3-carboxylic acid methyl ester

Methyl 2-aminopyridin-3-carboxylate

14667-47-1

pyridine

pharmacetical

Pyridine series

API intermediates