Methyl 5-aminopyridine-3-carboxylate

Uses

Product Name: Methyl 5-aminopyridine-3-carboxylate
CAS No.: 36052-25-2
Chemical Name: Methyl 5-aminopyridine-3-carboxylate
Synonyms: METHYL 5-AMINONICOTINATE;5-AMINO-NICOTINIC ACID METHYL ESTER;Methyl 5-amino-3-pyridinecarboxylate;methyl 5-aminopyridine-3-carboxylate;Methyl 5-aminopyridine-3-carboxylate ,98%;3-Pyridinecarboxylicacid,5-amino-,methylester;5-Aminopyridine-3-carboxylic acid methyl ester;5-Aminopyridine-3-carboxylic acid methyl ester ,98%;Methyl 5-aminopyridine-3-carboxylate, CAS 36052-25-2;5-AMINO-NICOTINIC ACID METHYL ESTER ISO 9001：2015 REACH
CBNumber: CB5129386
Molecular Formula: C7H8N2O2
Formula Weight: 152.15
MOL File: 36052-25-2.mol

More

Less

Methyl 5-aminopyridine-3-carboxylate Property

Melting point:: 135-137℃
Boiling point:: 319.4±22.0 °C(Predicted)
Density: 1.238
storage temp.: 2-8°C
pka: 4.13±0.20(Predicted)
form: solid
Appearance: Light brown to yellow Solid
BRN: 128569
InChI: InChI=1S/C7H8N2O2/c1-11-7(10)5-2-6(8)4-9-3-5/h2-4H,8H2,1H3
InChIKey: MBGSRKHDEJNWED-UHFFFAOYSA-N
SMILES: C1=NC=C(N)C=C1C(OC)=O

More

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38-26
Safety Statements: 26-36/37/38
WGK Germany: 3
HS Code: 29339900
Storage Class: 11 - Combustible Solids
Hazard Classifications: Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 672629
Product name: Methyl 5-aminopyridine-3-carboxylate
Purity: 97%
Packaging: 1g
Price: $138
Updated: 2025/07/31

Sigma-Aldrich

Product number: 672629
Product name: Methyl 5-aminopyridine-3-carboxylate
Purity: 97%
Packaging: 5g
Price: $583
Updated: 2023/06/20

TRC

Product number: M332918
Product name: Methyl5-Aminonicotinate
Packaging: 10mg
Price: $45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA51255
Product name: 5-Aminonicotinic acid methyl ester
Packaging: 1g
Price: $40
Updated: 2021/12/16

Matrix Scientific

Product number: 073368
Product name: Methyl 5-aminonicotinate
Purity: 95+%
Packaging: 1g
Price: $15
Updated: 2021/12/16

More

Less

Methyl 5-aminopyridine-3-carboxylate Chemical Properties,Usage,Production

Uses

It is used in organic synthesis and can be used as a starting material for the synthesis of 5-(hydroxymethyl)pyridine-3-ol.

Chemical Properties

Off-white solid

Synthesis

67-56-1

24242-19-1

36052-25-2

SOCl2 (10.4 g, 86.9 mmol) was slowly added dropwise to a stirred methanolic solution (100 mL) of 5-aminonicotinic acid (10.0 g, 72.5 mmol) at 0 °C. After gradually warming the reaction mixture to room temperature, the reaction was continued at reflux for 16 hours. After completion of the reaction, the mixture was cooled and concentrated under vacuum. The residue was diluted with deionized water (200 mL) and subsequently neutralized with aqueous NaHCO3 to pH=7. The aqueous phase mixture was extracted with dichloromethane (DCM, 100 mL x 2). The organic layers were combined, washed with saturated saline (100 mL × 2), dried over anhydrous Na2SO4, filtered, and the filtrate was concentrated to dryness under vacuum to give 9.5 g of methyl 5-aminopyridine-3-carboxylate as a white solid in 86% yield. The product was characterized by 1H NMR (DMSO-d6, 400 MHz): δ=8.24 (1H, d), 8.12 (1H, d), 7.42 (1H, dd), 5.65 (2H, brs), 3.84 (3H, s).

References

[1] Patent: WO2013/126608, 2013, A1. Location in patent: Paragraph 00492-00493
[2] Patent: WO2006/117549, 2006, A1. Location in patent: Page/Page column 97
[3] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 22, p. 6305 - 6310
[4] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 17, p. 6340 - 6350
[5] Chemistry - A European Journal, 2002, vol. 8, # 5, p. 1218 - 1226

Methyl 5-aminopyridine-3-carboxylate Preparation Products And Raw materials

Raw materials

Ninhydrin hydrate Ammonium hydroxide 5-Bromonicotinic acid Sodium sulfate Ethyl acetate Hydrochloric acid Sodium bicarbonate Copper(II) sulfate Methanol PETROLEUM ETHER

Preparation Products

More

Less

Methyl 5-aminopyridine-3-carboxylate Suppliers

China 105 Germany 1 India 2 Switzerland 1 United Kingdom 3 United States 20 Global 132

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 11997
Advantage: 60

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11034
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12984
Advantage: 57

Shijiazhuang Dowell Chemical Co., Ltd

Tel: 0311-89805679 17692413312
Fax: 0311-85262695
Email: sell@dowechem.com
Country: China
ProdList: 61
Advantage: 62

Nanjing Norris-Pharm Technology Co., Ltd

Tel: 18652989687
Fax: +86-25-52131256
Email: sales@norris-pharm.com
Country: China
ProdList: 8878
Advantage: 55

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66113011 17798518460
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 19906
Advantage: 55

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25378
Advantage: 65

More

Less

View Lastest Price from Methyl 5-aminopyridine-3-carboxylate manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 5-AMINO-NICOTINIC ACID METHYL ESTER 36052-25-2
Price: US $21.00/KG
Min. Order: 1KG
Purity: 99.0% min
Supply Ability: 100 tons
Release date: 2021-04-16

Career Henan Chemical Co

Product: 5-AMINO-NICOTINIC ACID METHYL ESTER 36052-25-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 96%
Supply Ability: 500kg
Release date: 2018-08-20

36052-25-2, Methyl 5-aminopyridine-3-carboxylateRelated Search:

3-METHOXYCARBONYL-5-NITRO-2(1H)-PYRIDINONE ETHYL 2-METHYL-5-NITRONICOTINATE Methyl-6-chloro-5-nitronicotinate 2-CHLORO-5-NITRONICOTINIC ACID METHYL ESTER 2-CHLORO-5-NITRONICOTINIC ACID ETHYL ESTER 5-AMINO-NICOTINIC ACID METHYL ESTER 4-Amino-nicotinic acid methyl ester ,97% 2-AMINO-NICOTINIC ACID METHYL ESTER 3-AMINO-ISONICOTINIC ACID METHYL ESTER Methyl 2-aminopyridine-4-carboxylate 3-Aminopyridine-2-carboxylic acid methyl ester 5-Aminonicotinic acid 4,6-Dihydroxy-5-nitropyridine-3-carboxylic acid ethyl ester 5-Amino-6-chloro-3-pyridinecarboxylic acid methyl ester methyl 6-amino-5-nitropyridine-3-carboxylate 5-AMINO-2-CHLORO-NICOTINIC ACID ETHYL ESTER 4,6-Dichloro-5-nitronicotinic acid ethyl ester TERT-BUTYL 5-AMINOPYRIDINE-3-CARBOXYLATE

METHYL 5-AMINONICOTINATE

5-AMINO-NICOTINIC ACID METHYL ESTER

Methyl 5-aminopyridine-3-carboxylate ,98%

5-Aminopyridine-3-carboxylic acid methyl ester

methyl 5-aminopyridine-3-carboxylate

Methyl 5-amino-3-pyridinecarboxylate

5-Aminopyridine-3-carboxylic acid methyl ester ,98%

3-Pyridinecarboxylicacid,5-amino-,methylester

5-AMINO-NICOTINIC ACID METHYL ESTER ISO 9001：2015 REACH

Methyl 5-aminopyridine-3-carboxylate, CAS 36052-25-2

36052-25-2

pharmacetical