ChemicalBook > CAS DataBase List > 6-Hydroxy-5-nitronicotinic acid

6-Hydroxy-5-nitronicotinic acid

Product Name
6-Hydroxy-5-nitronicotinic acid
CAS No.
6635-31-0
Chemical Name
6-Hydroxy-5-nitronicotinic acid
Synonyms
135339;6-Hydroxy-5-Nitro Niacin;6-hyroxy-5-nitronicotinic acid;6-HYDROXY-5-NITRONICOTINIC ACID;5-Nitro-6-hydroxynicotinic acid;6-Hydroxy-5-nitronicotinicAcid>5-CARBOXY-3-NITRO-2(1H)-PYRIDINONE;6-Hydroxy-5-nitronicotinic acid 97%;6-Hydroxy-5-nitropyridine-3-carboxylicaci;6-Hydroxy-5-nitropyridin-3-carboxylic acid
CBNumber
CB3671957
Molecular Formula
C6H4N2O5
Formula Weight
184.11
MOL File
6635-31-0.mol
More
Less

6-Hydroxy-5-nitronicotinic acid Property

Melting point:
269-271
Boiling point:
363.6±42.0 °C(Predicted)
Density 
1.70±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
form 
powder to crystal
pka
3.09±0.50(Predicted)
color 
Light yellow to Yellow
BRN 
177986
InChI
InChI=1S/C6H4N2O5/c9-5-4(8(12)13)1-3(2-7-5)6(10)11/h1-2H,(H,7,9)(H,10,11)
InChIKey
VJMXJGVEVASJOD-UHFFFAOYSA-N
SMILES
C1NC(=O)C([N+]([O-])=O)=CC=1C(O)=O
CAS DataBase Reference
6635-31-0(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37
Safety Statements 
26
WGK Germany 
3
Hazard Note 
Irritant/Keep Cold
HazardClass 
IRRITANT
HS Code 
2933399990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
669679
Product name
6-Hydroxy-5-nitropyridine-3-carboxylic acid
Purity
97%
Packaging
1g
Price
$118
Updated
2022/05/15
Sigma-Aldrich
Product number
669679
Product name
6-Hydroxy-5-nitropyridine-3-carboxylic acid
Purity
97%
Packaging
5g
Price
$704
Updated
2022/05/15
TCI Chemical
Product number
H1410
Product name
6-Hydroxy-5-nitronicotinic Acid
Purity
>97.0%(GC)(T)
Packaging
1g
Price
$105
Updated
2024/03/01
TCI Chemical
Product number
H1410
Product name
6-Hydroxy-5-nitronicotinic Acid
Purity
>97.0%(GC)(T)
Packaging
5g
Price
$360
Updated
2024/03/01
TRC
Product number
H950838
Product name
6-Hydroxy-5-nitronicotinic Acid
Packaging
500mg
Price
$65
Updated
2021/12/16
More
Less

6-Hydroxy-5-nitronicotinic acid Chemical Properties,Usage,Production

Uses

6-Hydroxy-5-nitronicotinic acid is mainly used as an antibacterial agent and pharmaceutical intermediate.

Chemical Reactivity

6-Hydroxy-5-nitronicotinic acid is stable under proper conditions, it reacts with oxidizing agents.

Synthesis

6-Hydroxy-5-nitronicotinic acid is synthesised using 6-Hydroxynicotinic acid as a raw material by chemical reaction. The specific synthesis steps are as follows:
6-Hydroxynicotinic acid 2 (25.0 g, 180 mmol) was dissolved in HNO3 fuming (1.52) (95 mL) and stirred at 50 oC for 18 h. After the solution was cooled to room temperature, the mixture was concentrated, and then co-evaporated with water, followed by the addition of MeOH to afford a brown precipitate. The precipitate was filtered and washed with 50 mL of cold MeOH twice. After drying under reduced pressure, a brown color product 3 was obtained; yield: 9.67 g (29percent); 1H NMR (300 MHz, CD3OD) 8.44 (d, J = 2.6 Hz, 1H), 8.85 (d, J = 2.6 Hz, 1H) ; HRMS (ES+): m/z 185.0194 (M+H+) (calcd for C6H5N2O5: 185.0198).

References

[1] Tetrahedron Letters, 1999, vol. 40, # 12, p. 2227 - 2230
[2] Tetrahedron Letters, 2012, vol. 53, # 5, p. 535 - 538
[3] Patent: WO2016/138335, 2016, A1. Location in patent: Paragraph 00372
[4] Journal of the American Chemical Society, 1956, vol. 78, p. 423
[5] Journal of the Chemical Society, 1951, p. 2590,2593

6-Hydroxy-5-nitronicotinic acid Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

6-Hydroxy-5-nitronicotinic acid Suppliers

Americas 1 China 226 Europe 1 France 1 Germany 3 India 14 Japan 1 United Kingdom 3 United States 19 Global 269
Shanghai Jinsheng Pharmaceutical Co., Ltd.
Tel
1365-13651960330 13651960330
Email
xiangfeixia@jspharmatech.com
Country
China
ProdList
356
Advantage
58
Shandong Zhonghan Pharmaceutical Co.,Ltd.
Tel
19862069201
Email
3844950497@qq.com
Country
China
ProdList
289
Advantage
55
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
ZHIWE CHEMTECH CO LTD
Tel
021-20221225 13917446399
Fax
QQ:115820162
Email
zwchem@163.com
Country
China
ProdList
616
Advantage
61
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
Advantage
56
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
Advantage
66
Beijing Ouhe Technology Co., Ltd
Tel
010-010-82967028 13522913783
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12000
Advantage
60
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9310
Advantage
66
Shangchem Co., Ltd.
Tel
+86-21-68182121
Fax
+86-21-68182121
Country
China
ProdList
882
Advantage
52
Suzhou Zehou Biotechnology Co. , Ltd.
Tel
0512-68716880 19984816880
Fax
18075373931
Email
sales@growingchem.com
Country
China
ProdList
212
Advantage
64
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9883
Advantage
59
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
16077
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
SHANGHAI HOHANCE CHEMICAL CO.,LTD
Tel
021-31115312 18217084087
Fax
86 021 31115317
Email
mary@hohance.com
Country
China
ProdList
165
Advantage
62
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11705
Advantage
57
ChangZhou SIDU chemical Co., Ltd.
Tel
0519-81291281 18015082300
Fax
0519-81291281
Email
siduchem@hotmail.com
Country
China
ProdList
274
Advantage
62
skychemical Co.Ltd
Tel
021-20958197 20965099
Fax
021-20960837
Email
sales@skychemical.com
Country
China
ProdList
1183
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
Advantage
57
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
Country
China
ProdList
7247
Advantage
62
Nanjing Vital Chemical Co., Ltd.
Tel
Please Send Email 18652950785
Fax
025-87193546
Email
chemweiao@163.com
Country
China
ProdList
4378
Advantage
65
Changzhou Standard Chemicals Ltd.
Tel
0519-85607885 13776800733
Fax
+86 519 8552788
Email
email@standardschem.com
Country
China
ProdList
114
Advantage
62
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9865
Advantage
52
Shanghai Jian Chao Chemical Technology Co., Ltd.
Tel
150-2103-5486 18017383231
Fax
qq：2817624287
Email
983544897@qq.com
Country
China
ProdList
9342
Advantage
55
China Shenyang Tyschem CO. ,LTD
Tel
+86-024-83607930; 18640359690
Fax
024-83607930
Email
sales@honghuchem.com
Country
China
ProdList
256
Advantage
58
Shanghai Yolne Chemical Co., Ltd.
Tel
021-62960152
Fax
021-52212593
Email
934678158@qq.com
Country
China
ProdList
9899
Advantage
55
Shanghai Raise Chemical Technology Co.,Ltd
Tel
+86-021-50935922
Fax
+86-021-33847795
Country
China
ProdList
7865
Advantage
55
AstaTech (Chengdu) Pharma. Co., Ltd.
Tel
15928766785 15928766785
Fax
QQ961458712
Email
wupengcheng@astatech.cn
Country
China
ProdList
1987
Advantage
55
Anhui Dexinjia Biopharm Co., Ltd
Tel
0531-82375892 15553111391
Email
3276840968@qq.com
Country
China
ProdList
301
Advantage
58
ShangHai Zexin Chemical Technology Co., Ltd.
Tel
021-60136491 15901897992
Fax
021-60136492
Country
China
ProdList
455
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Zhengzhou HongSheng Pharmaceutical Co., Ltd.
Tel
0371-0371-13526885213 15637198702
Fax
0371-63709726
Email
hsyykjchem@163.com
Country
China
ProdList
3853
Advantage
58
Porse Fine Chemical Co.,LTD
Tel
20-66003216 18666003216
Fax
+86-20-28069063
Email
info@porsefinechemical.com
Country
China
ProdList
1941
Advantage
62
Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
Country
China
ProdList
9637
Advantage
58
Wuhan Dahua Pharmaceutical Co., Ltd.
Tel
027-59262863 13277907145 3091977954
Fax
027-59420980
Country
China
ProdList
4942
Advantage
58
Shanghai Yongye Biotechnology Co., Ltd.
Tel
86-021-61559134 15921386130
Fax
021-55068248
Email
3423497944@qq.com
Country
China
ProdList
8144
Advantage
55
Shanghai Song Yuan Chemical Technology Co., Ltd.
Tel
010-1234567 18521000990
Fax
86-021-33275113
Email
sonyuanchemical@163.com
Country
China
ProdList
6479
Advantage
50
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66028182 18626450290
Email
yftan@aikonchem.com
Country
China
ProdList
16679
Advantage
50
Credit Asia Chemical Co., Ltd.
Tel
+86 (21) 61124340
Fax
+86 (21) 6129-4103
Country
China
ProdList
9756
Advantage
58
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51395
Advantage
80
Giant chemicals
Tel
028-85434334 18108076537
Fax
QQ：245797092
Email
market@gianthx.com
Country
China
ProdList
4505
Advantage
56
SPIRO PHARMA
Tel
Fax
-
Email
eric_feng1954@126.com
Country
China
ProdList
9248
Advantage
55
CHMA Chemical Technology (Shanghai) Co., Ltd
Tel
021-61556450 15800904410
Fax
021-61556450
Country
China
ProdList
2832
Advantage
58
Wuhan Chemwish Technology Co.， Ltd
Tel
027-67849912
Fax
027-87531808
Email
sales@chemwish.com
Country
China
ProdList
9148
Advantage
60
skychemical Co.Ltd
Tel
021-20960837,QQ1332204249
Fax
021-20960837
Email
sales@skychemical.com
Country
China
ProdList
3341
Advantage
55
Nanjing Vital Chemical Co., Ltd.
Tel
025-87193546 18652950785
Fax
025-87193546
Email
chemweiao@163.com
Country
China
ProdList
9021
Advantage
60
More
Less

View Lastest Price from 6-Hydroxy-5-nitronicotinic acid manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
6-Hydroxy-5-nitronicotinic acid 6635-31-0
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-13
Henan Aochuang Chemical Co.,Ltd.
Product
6-Hydroxy-5-nitronicotinic acid 6635-31-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-13
Shaanxi Dideu New Materials Co. Ltd
Product
6-Hydroxy-5-nitronicotinic acid 6635-31-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-02-12

6635-31-0, 6-Hydroxy-5-nitronicotinic acidRelated Search:

Oseltamivir phosphate 2,5-Dibromo-3-nitropyridine 2-PYRIDYLTHIOUREA 2-tert-Butyl-1,4-benzoquinone 5-Fluorotryptamine hydrochloride 3-Nitropyridine 3-Nitro-2-pyridinol 2-HYDROXY-5-NITRONICOTINIC ACID,2-Hydroxy-5-nitronicotinic acid 98% 5-NITRONICOTINIC ACID 3-AMINO-5-HYDROXYMETHYLPYRIDINE 6-Hydroxy-5-nitronicotinic acid 5-Aminonicotinic acid 2-Hydroxy-5-methyl-3-nitropyridine 4,6-Dihydroxy-5-nitropyridine-3-carboxylic acid ethyl ester 2-HYDROXY-3-AMINO-5-PICOLINE 2,6-Dimethoxy-5-nitropyridine-3-carboxylic Acid 5-NITRO-6-OXO-1,6-DIHYDRO-PYRIDINE-3-CARBOXYLIC ACID METHYL ESTER 5-NITRONICOTINALDEHYDE

  • 6-HYDROXY-5-NITRONICOTINIC ACID
  • 2-HYDROXY-3-NITRO-5-PYRIDINECARBOXYLIC ACID
  • 2-HYDROXY-3-NITROPYRIDINE-5-CARBOXYLIC ACID
  • 6-Hydroxy-5-nitronicotinic acid 97%
  • 5-CARBOXY-3-NITRO-2(1H)-PYRIDINONE
  • 6-hyroxy-5-nitronicotinic acid
  • 6-Hydroxy-5-nitropyridine-3-carboxylic acid, 5-Carboxy-2-hydroxy-3-nitropyridine
  • 135339
  • 6-Hydroxy-5-nitronicotinicAcid&gt
  • 3-Pyridinecarboxylic acid, 1,6-dihydro-5-nitro-6-oxo-
  • 6-Hydroxy-5-nitropyridine-3-carboxylicaci
  • 6-Hydroxy-5-nitro-3-pyridinecarboxylic Acid
  • 6-Hydroxy-5-nitronicotinic acid ISO 9001：2015 REACH
  • 6-Hydroxy-5-Nitro Niacin
  • 5-Nitro-6-hydroxynicotinic acid
  • 6-Hydroxy-5-nitropyridine-3-carboxylic acid, CAS 6635-31-0
  • 6-Hydroxy-5-nitropyridin-3-carboxylic acid
  • 6635-31-0
  • 6365-31-0
  • CHIRAL CHEMICALS
  • blocks
  • Carboxes
  • NitroCompounds
  • Pyridines