Methyl 4,6-dihydroxynicotinate
- Product Name
- Methyl 4,6-dihydroxynicotinate
- CAS No.
- 79398-27-9
- Chemical Name
- Methyl 4,6-dihydroxynicotinate
- Synonyms
- EOS-61393;4,6-dihydroxynicotinate;Methyl 4,6-dihydroxynicotinate;4,6-Dihydroxy-nicotinic acid methyl ester;Methyl 4,6-dihydroxypyridine-3-carboxylate;methyl 6-hydroxy-4-oxo-1H-pyridine-3-carboxylate;methyl 4-hydroxy-6-oxo-1H-pyridine-3-carboxylate;4,6-Dihydroxy-pyridin-3-carboxylic acid methyl ester;methyl 4-hydroxy-6-oxo-1,6-dihydropyridine-3-carboxylate;Methyl 4,6-dihydroxypyridine-3-carboxylate, 2,4-Dihydroxy-5-(m
- CBNumber
- CB61459485
- Molecular Formula
- C7H7NO4
- Formula Weight
- 169.13
- MOL File
- 79398-27-9.mol
Methyl 4,6-dihydroxynicotinate Property
- Melting point:
- 252-255°
- Boiling point:
- 331.7±42.0 °C(Predicted)
- Density
- 1.456±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 4.50±1.00(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C7H7NO4/c1-12-7(11)4-3-8-6(10)2-5(4)9/h2-3H,1H3,(H2,8,9,10)
- InChIKey
- YRIXOKHFULWNHE-UHFFFAOYSA-N
- SMILES
- C1NC(=O)C=C(O)C=1C(OC)=O
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M341575
- Product name
- methyl4,6-dihydroxynicotinate
- Packaging
- 500mg
- Price
- $240
- Updated
- 2021/12/16
- Product number
- 044647
- Product name
- Methyl 4,6-dihydroxynicotinate
- Purity
- >95%
- Packaging
- 500mg
- Price
- $43
- Updated
- 2021/12/16
- Product number
- 044647
- Product name
- Methyl 4,6-dihydroxynicotinate
- Purity
- >95%
- Packaging
- 1g
- Price
- $66
- Updated
- 2021/12/16
- Product number
- CS-0061857
- Product name
- Methyl4,6-dihydroxynicotinate
- Purity
- 99.03%
- Packaging
- 1g
- Price
- $72
- Updated
- 2021/12/16
- Product number
- W8494
- Product name
- Methyl4,6-dihydroxynicotinate
- Packaging
- 1g
- Price
- $150
- Updated
- 2021/12/16
Methyl 4,6-dihydroxynicotinate Chemical Properties,Usage,Production
Synthesis
1830-54-2
122-51-0
79398-27-9
General procedure for the synthesis of methyl 4,6-dihydroxynicotinate from dimethyl 1,3-acetone dicarboxylate and triethyl orthoformate: dimethyl 1,3-acetone dicarboxylate (2000 g, 11.5 mol), triethyl orthoformate (1947 mL, 11.5 mol), and acetic anhydride (2168 mL, 23.0 mol) were mixed and heated to react for 2 hr at 130°C. The reaction was carried out under vacuum. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently concentrated under vacuum to a volume of about 1500 mL.The concentrated crude product was cooled in an ice bath and ammonia (2 L) was added slowly with continuous stirring. Thirty minutes after the addition of ammonia, the pH of the mixture was adjusted to acidic with concentrated hydrochloric acid (about 300 mL), followed by filtration to obtain a suspension. The resulting crude product was dried under vacuum to finally obtain methyl 4,6-dihydroxynicotinate (900 g, 46% yield), which can be directly used in the subsequent reaction steps.
References
[1] Patent: US2012/184562, 2012, A1. Location in patent: Page/Page column 6; 17
[2] Patent: CN106854177, 2017, A. Location in patent: Paragraph 0016; 0018; 0024; 0030
[3] Patent: WO2014/210354, 2014, A1. Location in patent: Page/Page column 40
[4] Patent: WO2012/110860, 2012, A1. Location in patent: Page/Page column 98
Methyl 4,6-dihydroxynicotinate Preparation Products And Raw materials
Raw materials
Preparation Products
Methyl 4,6-dihydroxynicotinate Suppliers
- Tel
- 0573-11111111-1111 18969316891
- Fax
- -
- richmol@163.com
- Country
- China
- ProdList
- 449
- Advantage
- 50
- Tel
- 18083715844
- sales@milonpharm.com
- Country
- China
- ProdList
- 290
- Advantage
- 58
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 86-027-67849912
- Fax
- 86-027-87531808
- sales@chemwish.com
- Country
- China
- ProdList
- 35896
- Advantage
- 56
- Tel
- 13817811078
- Fax
- 86-021-50426522,50426273
- sales@jingyan-chemical.com
- Country
- China
- ProdList
- 9976
- Advantage
- 60
- Tel
- 0573-85285100 18627885956
- Fax
- 0573-85285100
- isenchem@163.com
- Country
- China
- ProdList
- 9310
- Advantage
- 66
- Tel
- 025-83697070
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 15883
- Advantage
- 64
- Tel
- 0531-88811783
- Fax
- +86 (531) 55696010 QQ 1762738062
- sales@trio-pharmatech.com
- Country
- China
- ProdList
- 1856
- Advantage
- 62
- Tel
- 0086-21-58956006
- Fax
- 0086-21-58956100
- Country
- China
- ProdList
- 7811
- Advantage
- 57
- Tel
- 0731-85526065 13308475853
- ivy@hnhbsj.com
- Country
- China
- ProdList
- 7247
- Advantage
- 62
View Lastest Price from Methyl 4,6-dihydroxynicotinate manufacturers
- Product
- Methyl 4,6-dihydroxynicotinate 79398-27-9
- Price
- US $3.00-9.00/KG
- Min. Order
- 0.1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2025-06-27
- Product
- Methyl 4,6-dihydroxynicotinate 79398-27-9
- Price
- US $1.00/KG
- Min. Order
- 25KG
- Purity
- 99.0%
- Supply Ability
- 3000KG/th
- Release date
- 2023-06-14
- Product
- Methyl 4,6-dihydroxynicotinate 79398-27-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kgs
- Release date
- 2020-02-17