DL-NORPHENYLEPHRINE HYDROCHLORIDE

Product Name: DL-NORPHENYLEPHRINE HYDROCHLORIDE
CAS No.: 4779-94-6
Chemical Name: DL-NORPHENYLEPHRINE HYDROCHLORIDE
Synonyms: WV 569;Coritat;Vingsal;Energona;Esbuphon;Stagural;Tonolift;Molycor R;NSC 100733;NSC 297582
CBNumber: CB9429008
Molecular Formula: C8H11NO2.ClH
Formula Weight: 189.64
MOL File: 4779-94-6.mol

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DL-NORPHENYLEPHRINE HYDROCHLORIDE Property

Melting point:: 162-164 °C(lit.)
storage temp.: -20°C Freezer, Under Inert Atmosphere
solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form: Solid
color: White to Off-White
Merck: 14,6699

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3
RTECS: DN7400000
HS Code: 2922504500
Toxicity: LD50 oral in rat: 390mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 1473206
Product name: Norphenylephrine hydrochloride
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 25mg
Price: $1490
Updated: 2024/03/01

Sigma-Aldrich

Product number: 113727
Product name: Norphenylephrine hydrochloride
Purity: 98%
Packaging: 10g
Price: $135
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHR1536
Product name: Norphenylephrine Hydrochloride
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 200mg
Price: $315
Updated: 2024/03/01

TRC

Product number: N825500
Product name: racNorphenylephrineHydrochloride(PhenylephrineImpurityA)
Packaging: 250mg
Price: $425
Updated: 2021/12/16

Biosynth Carbosynth

Product number: IN27563
Product name: rac-Norphenylephrine hydrochloride
Packaging: 100g
Price: $500
Updated: 2021/12/16

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DL-NORPHENYLEPHRINE HYDROCHLORIDE Chemical Properties,Usage,Production

Chemical Properties

white to almost white crystalline powder

Originator

Zordel,Grelan,Japan,1970

Uses

rac Norphenylephrine Hydrochloride is an Impurity A of phenylephrine. A phenylephrine derivative as leukotriene D4 antagonists.

Definition

ChEBI: Norfenefrine hydrochloride is a member of phenols.

Manufacturing Process

100 parts of the hydrochloride of meta-hydroxy-ω-aminoacetophenone of melting point 220°C to 222°C (obtainable by brominating metaacetoxyacetophenone, causing the bromoketone to react with sodium iodide, adding hexamethylenetetramine to the iodide in an indifferent solvent and scission of the addition product in acid solution) are shaken in aqueous solution with hydrogen in presence of 2 parts of palladium catalyst until 2 atomic proportions of hydrogen have been absorbed. The catalyst is now filtered and the filtrate evaporated in a vacuum; and the crystalline and completely dry residue is dissolved in absolute alcohol and a precipitate is produced by adding dry ether. The hydrochloride of metahydroxyphenylethanolamine thus obtained forms white crystals of melting point 159°C to 160°C.

Therapeutic Function

Adrenergic

DL-NORPHENYLEPHRINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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DL-NORPHENYLEPHRINE HYDROCHLORIDE Suppliers

Americas 1 Canada 1 China 64 Europe 2 Germany 2 India 9 Japan 1 Switzerland 1 United Kingdom 5 United States 12 Global 98

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
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Chemsky（shanghai）International Co.,Ltd.

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BOC Sciences

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S.Z. PhyStandard Bio-Tech. Co., Ltd.

Tel: 0755-4000505016 13380397412
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Email: 3001272453@qq.com
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ProdList: 5047
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TOKYO CHEMICAL INDUSTRY CO., LTD.

Tel: 03-36680489
Fax: 03-3668-0520
Email: Sales-JP@TCIchemicals.com
Country: Japan
ProdList: 28387
Advantage: 80

TCI Europe

Tel: 320-37350700
Fax: +32 (0)37350701
Email: sales@tcieurope.eu
Country: Europe
ProdList: 23671
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4779-94-6, DL-NORPHENYLEPHRINE HYDROCHLORIDERelated Search:

Phenylephrine hydrochloride 1,2,3,4-Tetrahydro-4,8-dihydroxy-2-methyl-isoquinoline Phenylephrine EP Impurity D Phenylephrine EP Impurity D 3-Hydroxy-4-[[(2R)-2-hydroxy-2-(3-hydroxyphenyl)ethyl]MethylaMino]-4-oxo-butanoic Acid 1,2,3,4-Tetrahydro-4,6-dihydroxy-2-methyl-isoquinoline N-ACETYL-4-BENZOQUINONE IMINE Phenylephrine Impurity 32 N-(2-Succinyl) Phenylephrine 2,2-Dichloro-1-(3-hydroxyphenyl)-ethanone benzyl(3-hydroxyphenacyl)methylammonium chloride N-Acetylphenylephrine DL-NORPHENYLEPHRINE HYDROCHLORIDE 1-(3-Hydroxyphenyl)-2-(methylamino)ethanone hydrochloride (R)-(-)-Phenylephrine-d3 HCl 2-AMINO-3'-HYDROXY-ACETOPHENONE HYDROCHLORIDE Phenylephrine Impurity 33 rac Benzyl Phenylephrine Norphenylephrine Hydrochloride

alpha-(aminomethyl)-3-hydroxy-benzenemethanohydrochloride

alpha-aminomethyl-3-hydroxy-benzylalcohohydrochloride

m-octopaminehydrochloride

norfenefrin

Phenylephrine Hydrochloride Impurity A

α-(AMinoMethyl)-3-hydroxybenzeneMethanol

3-(2-aMino-1-hydroxyethyl)phenol hydrochloride

Phenylephrine Impurity A HCl (racemic Norphenylephrine HCl)

Phenylephrine, Neosynephrine, Neophyrin, Mesaton

3-(2-amino-1-hydroxyethyl)phenol:hydron:chloride

Phenylephrine Impurity 16(Racemic Phenylephrine EP Impurity A HCl)

Phenylephrine Impurity A HCl

rac-Norphenylephrine hydrochloride

Racemic Phenylephrine EP Impurity A HCl

(+/-)-NORPHENYLEPHRINE HYDROCHLORIDE, 98 %

α-aminomethyl-3-hydroxybenzyl alcohol hydrochloride

1-(m-Hydroxyphenyl)-2-aminoethanol hydrochloride

2-Amino-1-(3-hydroxyphenyl)ethanol hydrochloride

Benzenemethanol, a-(aminomethyl)-3-hydroxy-, hydrochloride (9CI)

Benzyl alcohol, a-(aminomethyl)-m-hydroxy-, hydrochloride (6CI, 8CI)

Coritat

Depot-Novadral

dl-Norfenefrine hydrochloride

Energona

Esbuphon

Molycor R

nofenefrine hydrochloride

NSC 100733

NSC 297582

Stagural

Tonolift

Vingsal

WV 569

α-Aminomethyl-4-hydroxybenzyl alcohol hydrochloride

norphenephrinehydrochloride

A-AMINOMETHYL-M-HYDROXYBENZYLALCOHOL HYDROCHLORIDE

(+/-)-NORPHENYLEPHRINE HYDROCHLORIDE

NORPHENYLEPHRINE HYDROCHLORIDE

M-HYDROXYPHENYLAMINOETHANOL HYDROCHLORIDE

TIMTEC-BB SBB000279

rac Norphenylephrine Hydrochloride (Phenylephrine Impurity A)

rac-Phenylephrine EP Impurity A HCl

Phenylephrine Impurity A

Phenylephrine EP Impurity A Racemate

Etilefrine EP Impurity C

Octopamine Impurity 12

Benzenemethanol, a-(aminomethyl)-3-hydroxy-,hydrochloride (1:1)

DL-NORPHENYLEPHRINE HYDROCHLORIDE USP/EP/BP

Noradrenaline (Norepinephrine) Impurity 51

(RS)-NORPHENYLEPHRINE HYDROCHLORIDE

racemic Norphenylephrine HCl

Norphenylephrine Hydrochloride (1473206)

Phenylephrine EP Impurity A Racemate HCl

Phenylephrine Hydrochloride Impurity A as Racemate Hydrochloride

Etilefrine Hydrochloride Impurity C as Hydrochloride

Phenylephrine Hydrochloride EP Impurity A as Racemate Hydrochloride

Rac-Phenylephrine EP Impurity A HCl(Etilefrine EP Impurity C HCl)

Etilefrine Hydrochloride EP Impurity C as Hydrochloride