8-HYDROXYJULOLIDINE-9-ALDEHYDE
- Product Name
- 8-HYDROXYJULOLIDINE-9-ALDEHYDE
- CAS No.
- 63149-33-7
- Chemical Name
- 8-HYDROXYJULOLIDINE-9-ALDEHYDE
- Synonyms
- AKOS NCG-0055;9-Formyl-8-julolidinol;9-FORMYL-8-HYDROXYJULOLIDINE;8-hydroxyjulolodine-9-aldehyde;8-HYDROXYJULOLIDINE-9-ALDEHYDE;9-Formyl-8-hydroxyjulolidine, 97%,;8-HYDROXYJULOLIDINE-9-CARBOXALDEHYDE;8-Hydroxyjulolidine-9-carboxaldehyde>9-FORMYL-2,3,6,7-TETRAHYDRO-1H,5H-BENZO[IJ]QUINOLIZIN-8-OL;2,3,6,7-TETRAHYDRO-8-HYDROXY-1H,5H-BENZO[IJ]QUINOLIZINE-9-CARBALDEHYDE
- CBNumber
- CB9440223
- Molecular Formula
- C13H15NO2
- Formula Weight
- 217.26
- MOL File
- 63149-33-7.mol
8-HYDROXYJULOLIDINE-9-ALDEHYDE Property
- Melting point:
- 69-73°C
- Boiling point:
- 417.3±45.0 °C(Predicted)
- Density
- 1.30±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 9.47±0.20(Predicted)
- color
- White to Amber to Dark green
- InChI
- InChI=1S/C13H15NO2/c15-8-10-7-9-3-1-5-14-6-2-4-11(12(9)14)13(10)16/h7-8,16H,1-6H2
- InChIKey
- NRZXBDYODHLZBF-UHFFFAOYSA-N
- SMILES
- C12=CC(C=O)=C(O)C3=C1N(CCC3)CCC2
- CAS DataBase Reference
- 63149-33-7(CAS DataBase Reference)
- EPA Substance Registry System
- 1H,5H-Benzo[ij]quinolizine-9-carboxaldehyde, 2,3,6,7-tetrahydro-8-hydroxy- (63149-33-7)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 404640
- Product name
- 2,3,6,7-Tetrahydro-8-hydroxy-1H,5H-benzo[ij]quinolizine-9-carboxaldehyde
- Purity
- 98%
- Packaging
- 1g
- Price
- $119.45
- Updated
- 2025/07/31
- Product number
- H1225
- Product name
- 8-Hydroxyjulolidine-9-carboxaldehyde
- Purity
- >96.0%(GC)(T)
- Packaging
- 5g
- Price
- $197
- Updated
- 2025/07/31
- Product number
- CDX-H0021-G001
- Product name
- 8-Hydroxyjulolidine-9-aldehyde
- Purity
- ≥98%(HPLC)
- Packaging
- 1g
- Price
- $53
- Updated
- 2021/12/16
- Product number
- 41808
- Product name
- 2,3,6,7-Tetrahydro-8-hydroxy-1H,5H-benzo[ij]quinolizine-9-carboxaldehyde,≥97.5%(GC),suitableforHematology&Histology
- Purity
- ≥97.5%(GC)
- Packaging
- 1G
- Price
- $100.17
- Updated
- 2021/12/16
- Product number
- CS-0060782
- Product name
- 8-Hydroxy-2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinoline-9-carbaldehyde
- Packaging
- 5g
- Price
- $146
- Updated
- 2021/12/16
8-HYDROXYJULOLIDINE-9-ALDEHYDE Chemical Properties,Usage,Production
Uses
8-Hydroxyjulolidine-9-carboxaldehyde is a reactant in the development of iminocoumarin-based zinc sensor suitable for ratiometric fluorescence imaging of neuronal zinc.
Synthesis
41175-50-2
68-12-2
63149-33-7
The general procedure for the synthesis of 8-hydroxy-1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinoline-8-ol and N,N-dimethylformamide (DMF) to synthesize 8-hydroxy-1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinoline-9-carboxaldehyde was carried out in the following manner: at 4 °C, a flask containing 10 mL DMF was slowly charged dropwise with chlorine phosphorus oxide (2.7 mL, 4.4 g, 29 mmol), and the dropwise addition process lasted for 15 min. Subsequently, a solution of 8-hydroxy-1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinolin-8-ol (5.15 g, 26.9 mmol) in DMF (5 mL) was added dropwise to the above mixture over 10 minutes. After dropwise addition, the reaction mixture was stirred at room temperature for 30 min, then warmed up to 100 °C and continued stirring for 30 min. Upon completion of the reaction, the mixture was cooled to room temperature and 30 mL of water was added to the stirring dark solution. The aqueous mixture was stirred for 1.5 hours until a blue-green precipitate formed. The precipitate was separated by filtration, washed with water and dried. The crude product was purified by silica gel column chromatography with an eluent of toluene/ethyl acetate (2:1 v/v). The final product yield was 94% and the melting point was 205°C (literature value 73-74°C).
References
[1] Chemical Communications, 2014, vol. 50, # 69, p. 9947 - 9950
[2] Journal of the American Chemical Society, 2003, vol. 125, # 16, p. 4708 - 4709
[3] Journal of Fluorescence, 2015, vol. 25, # 6, p. 1615 - 1628
[4] Organic Preparations and Procedures International, 2001, vol. 33, # 6, p. 603 - 613
[5] Journal of Organic Chemistry, 1987, vol. 52, # 8, p. 1465 - 1468
8-HYDROXYJULOLIDINE-9-ALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
8-HYDROXYJULOLIDINE-9-ALDEHYDE Suppliers
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
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View Lastest Price from 8-HYDROXYJULOLIDINE-9-ALDEHYDE manufacturers
- Product
- 9-ForMyl-8-hydroxyjulolidine 63149-33-7
- Price
- US $0.00-0.00/g
- Min. Order
- 10mg
- Purity
- 99%HPLC
- Supply Ability
- 2000tons
- Release date
- 2020-01-15
- Product
- 8-Hydroxyjulolidine-9-aldehyde 63149-33-7
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%, 99.5% Sublimated
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-31
- Product
- 8-HYDROXYJULOLIDINE-9-ALDEHYDE 63149-33-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500kg
- Release date
- 2020-01-02