Pyrantel pamoate
- Product Name
- Pyrantel pamoate
- CAS No.
- 22204-24-6
- Chemical Name
- Pyrantel pamoate
- Synonyms
- pirantel pamoate;pyrantelembonate;helmex;NeMocid;embovin;Piranver;HelMintox;cobantril;antiminth;Early Bird
- CBNumber
- CB9440425
- Molecular Formula
- C34H30N2O6S
- Formula Weight
- 594.68
- MOL File
- 22204-24-6.mol
Pyrantel pamoate Property
- Melting point:
- 266-267°C
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Pratically insoluble in water, soluble in dimethyl sulfoxide, pratically insoluble in methanol.
- form
- powder
- color
- yellow
- Water Solubility
- <0.1 g/100 mL at 19 ºC
- BRN
- 9034755
- BCS Class
- 4
- InChI
- InChI=1S/C23H16O6.C11H14N2S/c24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29;1-13-8-3-7-12-11(13)6-5-10-4-2-9-14-10/h1-10,24-25H,11H2,(H,26,27)(H,28,29);2,4-6,9H,3,7-8H2,1H3/b;6-5+
- InChIKey
- AQXXZDYPVDOQEE-MXDQRGINSA-N
- SMILES
- C(C1=C(C(C(=O)O)=CC2=CC=CC=C12)O)C1=C(C(C(=O)O)=CC2=CC=CC=C12)O.C(/C1=NCCCN1C)=C\C1SC=CC=1
- EPA Substance Registry System
- 2-Naphthalenecarboxylic acid, 4,4'-methylenebis[3-hydroxy-, compd. with 1,4,5,6-tetrahydro-1-methyl-2-[(1E)-2-(2-thienyl)ethenyl]pyrimidine (1:1) (22204-24-6)
Safety
- WGK Germany
- 3
- RTECS
- QL2287000
- HS Code
- 2934990002
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 46702
- Product name
- Pyrantel pamoate
- Purity
- VETRANAL
- Packaging
- 250mg
- Price
- $79.8
- Updated
- 2024/03/01
- Product number
- 1584003
- Product name
- Pyrantel pamoate
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 500mg
- Price
- $436
- Updated
- 2024/03/01
- Product number
- 27368
- Product name
- Pyrantel (pamoate)
- Packaging
- 5g
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 27368
- Product name
- Pyrantel (pamoate)
- Packaging
- 10g
- Price
- $68
- Updated
- 2024/03/01
- Product number
- Y0000402
- Product name
- Pyrantel embonate
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- y0000402
- Price
- $153
- Updated
- 2024/03/01
Pyrantel pamoate Chemical Properties,Usage,Production
Description
Pyrantel is a tasteless, odorless, yellow, crystalline solid. It is insoluble inwater, slightly soluble in dimethylformamide, and soluble in dimethyl sulfoxide.
Chemical Properties
Pale yellow or yellow powder.
Uses
An antiparasitic agent used in the treatment of intestinal parasites such as hookworms and roundworms (Ascaris lumbricoides, aka ascarids in humans) in domesticated animals such as horses, cattle, sheep, pigs, cats, dogs, and many other species.
Uses
anthelmintic
Indications
Pyrantel pamoate (Antiminth) is a agonist at the nicotinic acetylcholine receptor, and its actions result in depolarization and spastic paralysis of the helminth muscle. Its selective toxicity occurs primarily because the neuromuscular junction of helminth muscle is more sensitive to the drug than is mammalian muscle. This drug is administered orally, and because very little is absorbed, high levels are achieved in the intestinal tract. Less than 15% of the drug and its metabolites are excreted in urine.
Definition
ChEBI: Pyrantel pamoate is an organic molecular entity.
brand name
Antiminth (Roerig); Combantrin (Pfizer).
General Description
Odorless light yellow to tan crystalline powder. Tasteless. Used medicinally against nematodes in animals.
Air & Water Reactions
May be sensitive to prolonged exposure to air and light . Insoluble in water.
Reactivity Profile
Pyrantel pamoate may react with acids to liberate heat. May react exothermically enough with strong oxidizing acids to ignite the reaction products. Heat is also generated with caustic solutions. Generates flammable or toxic gases with alkali metals and hydrides and other reducing agents.
Fire Hazard
Flash point data for Pyrantel pamoate are not available; however, Pyrantel pamoate is probably combustible.
Mechanism of action
Pyrantel is a depolarizing neuromuscular blocking agent. In nematodes it causes a slowly developing contraction and paralysis. The immobilized parasites are then eliminated from the intestine. The neuromuscular junction of Ascaris is 100-fold more sensitive to pyrantel than to acetylcholine .
Clinical Use
Trans-1,4,5,6,-Tetrahydro-1-methyl-2-[2-(2 -thienyl)ethenyl]pyrimidine pamoate (Antiminth) is a depolarizing neuromuscularblocking agent that causes spastic paralysis insusceptible helminths. It is used in the treatment of infestationscaused by pinworms and roundworms (ascariasis).Because its action opposes that of piperazine, the twoanthelmintics should not be used together. More than halfof the oral dose is excreted in the feces unchanged.Adverse effects associated with its use are primarilygastrointestinal.
Side effects
Pyrantel pamoate is active against several roundworms:
A. lumbricoides, Ancylostoma duodenale, Necator
americanus, and E. vermicularis. Pyrantel is an alternative
drug of choice in treating infections with A. lumbricoides,
E. vermicularis (pinworms), and hookworms
(N. americanus and A. duodenale). It is not recommended
for pregnant patients or for children under age
1 year.
Although most of the drug remains in the intestinal
lumen, enough can be absorbed systemically to cause
headache, dizziness, and drowsiness. No major adverse
effects have been reported on renal, hepatic, or hematological
systems.
Veterinary Drugs and Treatments
Pyrantel has been used for the removal of the following parasites
in dogs: ascarids (Toxocara canis, T. leonina), hookworms
(Ancylostoma caninum, Uncinaria stenocephala), and stomach
worm (Physaloptera). Although not approved for use in cats, it is
useful for similar parasites and is considered safe to use.
Pyrantel is indicated (labeled) for the removal of the following
parasites in horses: Strongylus vulgaris and equinus, Parasacaris
equorum, and Probstymayria vivapara. It has variable activity
against Oxyuris equi, S. edentatus, and small strongyles. Pyrantel is
active against ileocecal tapeworm (A. perfoliata) when used at twice
the recommended dose, although resistance has been reported.
Although there are apparently no pyrantel products approved
for use in cattle, sheep, or goats, the drug is effective (as the tartrate)
for the removal of the following parasites: Haemonchus spp.,
Ostertagia spp., Trichostrongylus spp., Nematodirus spp., Chabertia
spp., Cooperia spp. and Oesophagostomum spp.
Pyrantel tartrate is indicated (labeled) for the removal or prevention
of the following parasites in swine: large roundworms (Ascaris
suum) and Oesophagostomum spp. The drug has activity against the
swine stomach worm (Hyostrongylus rubidus).
Although not approved, pyrantel has been used in pet birds and
llamas. See the Dosage section for more information.
Pyrantel pamoate Preparation Products And Raw materials
Raw materials
Preparation Products
Pyrantel pamoate Suppliers
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View Lastest Price from Pyrantel pamoate manufacturers
- Product
- Pyrantel pamoate 22204-24-6
- Price
- US $15.00/kg
- Min. Order
- 1kg
- Purity
- 99.912%
- Supply Ability
- 10ton
- Release date
- 2024-04-25
- Product
- Pyrantel Pamoate 22204-24-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98.00%
- Supply Ability
- 1000kg
- Release date
- 2022-12-21
- Product
- Pyrantel pamoate 22204-24-6
- Price
- US $110.00-90.00/kilogram
- Min. Order
- 1kilogram
- Purity
- 99%
- Supply Ability
- 10 tons/per week
- Release date
- 2023-12-12