ChemicalBook > CAS DataBase List > (R)-(-)-2-Methylpiperazine

(R)-(-)-2-Methylpiperazine

Product Name
(R)-(-)-2-Methylpiperazine
CAS No.
75336-86-6
Chemical Name
(R)-(-)-2-Methylpiperazine
Synonyms
R-MP;NNX3;URI1;C19orf2;PPP1R19;(R)-2-methylpiperadine;(R)-2-METHYLPIPERAZINE;(2R)-2-Methylpiperazine;Phenylephrine Impurity 84;(R)-(-)-2-METHYLPIPERAZINE
CBNumber
CB9445086
Molecular Formula
C5H12N2
Formula Weight
100.16
MOL File
75336-86-6.mol
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(R)-(-)-2-Methylpiperazine Property

Melting point:
91-93 °C (lit.)
Boiling point:
155-156 °C
alpha 
-18 º (c=1, toluene)
Density 
0.9305 (estimate)
refractive index 
1.4378 (estimate)
Flash point:
149 °F
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
9.31±0.40(Predicted)
form 
Crystalline Powder, Crystals and/or Chunks
color 
White to yellow
optical activity
[α]20/D 16.5°, c = 5 in benzene
Water Solubility 
soluble
Sensitive 
Air Sensitive & Hygroscopic
BRN 
3647994
CAS DataBase Reference
75336-86-6(CAS DataBase Reference)
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Safety

Hazard Codes 
F,C,Xi
Risk Statements 
11-36/37/38-34
Safety Statements 
16-26-36/37/39-45-36
RIDADR 
UN 1325 4.1/PG 2
WGK Germany 
2
HazardClass 
4.1
PackingGroup 
III
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H228Flammable solid

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
397164
Product name
(R)-(?)-2-Methylpiperazine
Purity
97%
Packaging
1g
Price
$37.54
Updated
2025/07/31
Sigma-Aldrich
Product number
SAB1305286
Product name
ANTI-RMP (URI)(C-TERMINAL) antibody produced in rabbit
Purity
IgG fraction of antiserum, buffered aqueous solution
Packaging
400μL
Price
$461
Updated
2023/01/07
TCI Chemical
Product number
M2091
Product name
(R)-(-)-2-Methylpiperazine
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$116
Updated
2025/07/31
TCI Chemical
Product number
M2091
Product name
(R)-(-)-2-Methylpiperazine
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$368
Updated
2025/07/31
TRC
Product number
M725643
Product name
(R)-(-)-2-Methylpiperazine
Packaging
50mg
Price
$45
Updated
2021/12/16
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(R)-(-)-2-Methylpiperazine Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystalline powder

Uses

Valuable synthon for quinoline antibacterials.

Synthesis

126458-16-0

75336-86-6

General procedure for the synthesis of (R)-(-)-2-methylpiperazine L-tartrate from (R)-2-methylpiperazine L-tartrate: (R)-2-methylpiperazine L-tartrate (from Example 4) was dissolved in water (182 L) and branched octane (200 L), added to a 4,000 L reactor and stirred until completely dissolved. Subsequently, more branched octane (530 L) was added to the reactor and a 50% sodium hydroxide solution (1120 kg) was slowly added over a temperature range of 35°C to 52°C. The reaction mixture was heated to 80 °C with continuous stirring for 2 h. The lower aqueous phase was then separated and transferred to a 4000 L receiver. The organic phase in the reactor was cooled to 21°C, filtered through a 48-inch Nutsche filter, and the filtrate was transferred to a 1200L reactor. The 4000L reactor and filter were rinsed with branched octane (300L). The solid product was dried over nitrogen at 25 °C to give a final 24.9 kg (67% yield) of (R)-(-)-2-methylpiperazine with an optical purity of not less than 99% ee (as determined by chiral HPLC). The pH of the aqueous phase in the receiver was adjusted to 8.4 with acetic acid (812 kg) prior to treatment.The overall yield of (R)-(-)-2-methylpiperazine was 42% starting from (R)-2-methylpiperazine L-tartrate. The melting point of the product was 91-93 °C.1H NMR (400 MHz, CDCl3) δ: 2.97-2.68 (6H, m), 2.35 (1H, dd, J = 11.7, 10.2 Hz), 1.61 (2H, s), 1.00 (3H, d, J = 6.7 Hz), 0.00 (TMS, ref).13C NMR ( 100MHz, CDCl3) δ: 54.14(t), 51.89(d), 47.43(t), 46.46(t), 20.08(q), 0.00 (TMS, ref.) IR (mineral oil paste) νmax: 3220(s, br), 2819(s), 2748, 2042(w), 1995(w), 1981(w), 1328, 1328(s, d, J = 6.7Hz), 0.00 (TMS, ref.). (w), 1328, 1279, 1137, 1094, 960, 859(s), 845(s), 795(s), 621(s) cm-1. HRMS (FAB) calculated value for C5H12N2 [M+H]+: 101.1079, measured value: 101.1080. [α]25D = -17° (c 0.85, CH2Cl2). Elemental analysis calculated values for C5H12N2: C, 59.96; H, 12.07; N, 27.97. measured values: C, 59.25; H, 11.71; N, 27.64.

References

[1] Patent: WO2004/829, 2003, A1. Location in patent: Page 25-26

(R)-(-)-2-Methylpiperazine Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-(-)-2-Methylpiperazine Suppliers

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View Lastest Price from (R)-(-)-2-Methylpiperazine manufacturers

Shenzhen Nexcon Pharmatechs Ltd.
Product
(R)-(-)-2-Methylpiperazine 75336-86-6
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
2000
Release date
2025-06-10
Hebei Ganmiao New material Technology Co., LTD
Product
(R)-(-)-2-Methylpiperazine 75336-86-6
Price
US $10.00-7.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
20ton
Release date
2024-06-06
Hebei Zhanyao Biotechnology Co. Ltd
Product
R)-(-)-2-Methylpiperazine 75336-86-6
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 Tons
Release date
2021-10-14

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