Tibolone
- Product Name
- Tibolone
- CAS No.
- 5630-53-5
- Chemical Name
- Tibolone
- Synonyms
- LIVIAL;Tiblone;LIVIELLA;TIBOLONE;Tiboione;tibolona;Org OD 14;tibolonum;Tibolone(EP);Tibolone IMpurity
- CBNumber
- CB9453050
- Molecular Formula
- C21H28O2
- Formula Weight
- 312.45
- MOL File
- 5630-53-5.mol
Tibolone Property
- Melting point:
- 169 °C
- Boiling point:
- 447.4±45.0 °C(Predicted)
- Density
- 1.13±0.1 g/cm3(Predicted)
- refractive index
- 105 ° (C=0.54, CH2Cl2/Et2O)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble15mg/mL, clear
- pka
- 13.10±0.60(Predicted)
- color
- white to beige
- Merck
- 9427
- InChI
- InChI=1/C21H28O2/c1-4-21(23)10-8-18-19-13(2)11-14-12-15(22)5-6-16(14)17(19)7-9-20(18,21)3/h1,13,17-19,23H,5-12H2,2-3H3/t13-,17-,18+,19-,20+,21+/s3
- InChIKey
- WZDGZWOAQTVYBX-PGFZCDQENA-N
- SMILES
- [C@@]12([H])[C@H](C)CC3CC(=O)CCC=3[C@@]1([H])CC[C@]1(C)[C@](CC[C@@]21[H])(O)C#C |&1:0,2,12,16,18,21,r|
- CAS DataBase Reference
- 5630-53-5(CAS DataBase Reference)
Safety
- Hazard Codes
- N
- Risk Statements
- 51/53
- Safety Statements
- 22-24/25-61
- RIDADR
- UN 3077 9/PG 3
- RTECS
- RC8964020
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- Y0000668
- Product name
- Tibolone for system suitability
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- y0000668
- Price
- $153
- Updated
- 2024/03/01
- Product number
- 10006321
- Product name
- Tibolone
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $34
- Updated
- 2024/03/01
- Product number
- 10006321
- Product name
- Tibolone
- Purity
- ≥98%
- Packaging
- 250 mg
- Price
- $81
- Updated
- 2024/03/01
- Product number
- 10006321
- Product name
- Tibolone
- Purity
- ≥98%
- Packaging
- 500mg
- Price
- $152
- Updated
- 2024/03/01
- Product number
- 10006321
- Product name
- Tibolone
- Purity
- ≥98%
- Packaging
- 1 g
- Price
- $287
- Updated
- 2024/03/01
Tibolone Chemical Properties,Usage,Production
Description
Tibolone is a synthetic steroid with weak progestational and estrogenic properties, reportedly useful in controlling symptoms resulting from natural or surgical menopause. It has thus far shown no significant antithrombotic effect in post-menopausal patients.
Chemical Properties
White Solid
Originator
Akzo (Organon) (The Netherklands)
Uses
A synthetic steroid with weak estrogenic, androgenic and progestogenic activity. A pharamceutical used in the treatment of menopausal syndrome
Definition
ChEBI: Estran-3-one with a double bond between positions 5 and 10, and bearing both an ethynyl group and a hydroxy group at position 17 (R-configuration). A synthetic steroid hormone drug which acts as an agonist at all five type I steroid hormon receptors, it is used in the prevention of postmenopausal osteoporosis and for treatment of endometriosis.
brand name
Livial
Pharmacokinetics
Raloxifene is rapidly absorbed following oral administration, with an estimated 60% absorption, but it has a very low bioavailability (2%), associated with extensive phase II metabolism. The metabolites are excreted via the bile, with potential enterohepatic recycling that could account for the interaction with cholestyramine. Supportive of the enterohepatic recycling is the half-life of 28 hours. Metabolism of raloxifene occurs to a great extent in the intestine and consists of glucuronide conjugation catalyzed by uridine diphosphate glucuronosyltransferase (UGT).
Clinical Use
Tibolone is a synthetic steroid that has been shown to increase bone mineral density similar to alendronate. The U.S. FDA approval is pending; overseas, this agent is used for the treatment of menopausal symptoms as well as the prevention of osteoporosis. It is considered to be a viable alternative to conjugated equine estrogen plus micronized progesterone.
Side effects
The most common reason for patient withdrawal from clinical trials was vaginal bleeding (also a common side effect when estrogen therapy is used).
Tibolone Preparation Products And Raw materials
Raw materials
Preparation Products
View Lastest Price from Tibolone manufacturers
- Product
- Tibolone 5630-53-5
- Price
- US $10.00-100.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100 tons
- Release date
- 2024-01-18
- Product
- Tibolone 5630-53-5
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000kg
- Release date
- 2023-11-01
- Product
- Tibolone 5630-53-5
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000kg
- Release date
- 2023-12-07