Pergolide mesylate salt

ChemicalBook > CAS DataBase List > Pergolide mesylate salt

Pergolide mesylate salt

Product Name: Pergolide mesylate salt
CAS No.: 66104-23-2
Chemical Name: Pergolide mesylate salt
Synonyms: MPE;Nopar;Permax;Celance;Veceral;Pergolin;ly127809;NSC 319773;PERGOLIDE MESYLATE;Pergolide mesilate CRS
CBNumber: CB9455089
Molecular Formula: C20H30N2O3S2
Formula Weight: 410.59
MOL File: 66104-23-2.mol

Less

Pergolide mesylate salt Property

Melting point:: 252-254°C
alpha: aD20 between -18.0° and -23.0° (c = 10 mg/ml in DMF)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: ethanol: soluble2mg/mL
form: solid
pka: pKa (66% DMF) 7.8(at 25℃)
color: white
optical activity: [α]20/D 35°, c = 0.2 in pyridine(lit.)
InChIKey: UWCVGPLTGZWHGS-PLBOZXOQNA-N
SMILES: C12=C3C=CC=C1[C@@]1([H])C[C@H](CN(CCC)[C@]1([H])CC2=CN3)CSC.S(=O)(=O)(O)C |&1:6,9,15,r|
CAS DataBase Reference: 66104-23-2(CAS DataBase Reference)

Less

Safety

Hazard Codes: T+
Risk Statements: 28
Safety Statements: 28-36/37-45
RIDADR: UN 1544
WGK Germany: 3
RTECS: KE6345000
HS Code: 2939690000

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H300Fatal if swallowed

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 1510845
Product name: Pergolide mesylate
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $510
Updated: 2024/03/01

Cayman Chemical

Product number: 26085
Product name: Pergolide (mesylate)
Purity: ≥95%
Packaging: 25mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 26085
Product name: Pergolide (mesylate)
Purity: ≥95%
Packaging: 50mg
Price: $107
Updated: 2024/03/01

Sigma-Aldrich

Product number: Y0000010
Product name: Pergolide mesilate
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: y0000010
Price: $220
Updated: 2024/03/01

Cayman Chemical

Product number: 26085
Product name: Pergolide (mesylate)
Purity: ≥95%
Packaging: 100mg
Price: $177
Updated: 2024/03/01

Less

Pergolide mesylate salt Chemical Properties,Usage,Production

Description

Pergolide mesylate is a potent, long-acting dopamine agonist useful in the treatment of Parkinson’s disease and hyperprolactinemia, Compared with lergotrile, pergolide mesylate has shown less toxicity and lower propensity for inducing psychosis.

Description

Pergolide is a potent dopamine D₁ and D₂ receptor agonist (K_is = 111 and 0.495 nM, respectively, for rat striatal receptors). It depresses dopaminergic firing in paralyzed rats (ED₅₀ = <20 μg/kg), an effect that can be reversed by the dopamine D₂-selective antagonist spiperone or the dopamine D₁-selective antagonist SCH 23390 . Pergolide (0.025 and 0.05 mg/kg) increases the volume threshold for inducing bladder contraction in a cynomolgus monkey model of Parkinson''s disease induced by MPTP. It also reduces carrageenan-induced paw edema in adrenalectomized rats (ED₅₀ = 0.4 mg/kg).

Chemical Properties

White to Off-White Solid

Originator

Lilly (USA)

Uses

A dopaminergic agonist that also decrease plasma prolactin concentrations. An antiparkinsonian agent

Uses

glucocorticoid, antiinflammatory

Uses

dopamine receptor agonist, anti-Parkinson's agent

Definition

ChEBI: A methanesulfonate salt obtained from pergolide by mixing eqimolar amount of pergolide and methanesulfonic acid. A dopamine D2 receptor agonist which also has D1 and D2 agonist properties, it i used in the management of Parkinson's disease, although it was withdrawn from the U.S. and Canadian markets in 2007 due to an increased risk of cardiac valve dysfunction.

Manufacturing Process

Dimethyl disulfide (73.6 ml, 0.79 mol) and tri-n-butylphosphine (79.6 ml, 0.32 mol) were added to a solution of 9,10-dihydrolysergol in (8.1 g, 0.032 mol) in the 150 ml of anhydrous DMF and were stirred at room temperature for 6 hours under a nitrogen atmosphere. Dimethyl disulfide of the reaction mixture was removed under vacuo. A solution of the residue in ethyl acetate was extracted with 3.7% HCl (aq.). The aqueous layer was basified with ammonium hydroxide to a pH of 10 and then extracted with ethyl acetate. Removal of ethyl acetate followed by a silica gel column purification eluting with 10% MeOH/CH2Cl2 gave5.5.g of D-6-methyl-8β(methylthiomethyl)ergoline (60%).
A solution of D-6-methyl-8β-(methylthiomethyl)ergoline (0.4 g, 0.0014 mol) and NaI (0.63 g, 0.0042 mol) in 10 ml of propionic anhydride was refluxed for 40 hours. The reaction mixture was guenched with a 10% Na2CO3 solution and extracted by ethyl acetate. The combined organic layers were washed with a saturated brine solution, dried with magnesium sulfate and concentrated to produce oil. The oil was purified by silica gel column, eluting with 10% MeOH/CH2Cl2 to give 0.33 g of D-1,6-dipropionyl-8β(methylthiomethyl)ergoline.
LiAlH4 (0.6 g, 0.0156 mol) was slowly added to a solution of D-1,6dipropionyl-8β-(methylthiomethyl)ergoline in the 20 ml anhydrous THF at 0°C under nitrogene atmosphere. The mixture was stirred at 0°C for 30 min and then at room temperature for 4 hours. The reaction was cooled to 0°C and 0.6 ml of water was slowly added. The mixture was stirred at 0°C for 10 min and 1.8 ml of 15% NaOH (aq.) and 2.5 ml of water were added respectively. The mixture was stirred for 30 min at room temperature and then filtered. Excess of the solvent was removed under reduced pressure to give 150 mg of 8β-((methylthio)methyl)-6-propyl-ergoline or pergolide (yield: 68%). Ergoline,8-((methylthio)methyl)-6-propyl-, monomethanesulfonate, (8β)- may be prepared by mixing of components in solution.

brand name

Permax (Valeant).

Therapeutic Function

Dopamine agonist

Biochem/physiol Actions

Dopaminergic agonist; suppresses pituitary secretion of prolactin; anti-Parkinsonian agent.

Pergolide mesylate salt Preparation Products And Raw materials

Raw materials

Preparation Products

Pergolide

Less

Pergolide mesylate salt Suppliers

Canada 1 China 113 Europe 2 Germany 1 India 1 Spain 1 Switzerland 1 United Kingdom 7 United States 25 Global 152

Tianjin Keluo Pharmaceutical Technology Co. LTD

Tel: 022-23869539 18920052327
Fax: 022-83711180
Email: 281258989@qq.com
Country: China
ProdList: 59
Advantage: 58

GUANGZHOU TOPWORK CHEMISTRY CO.,LTD.

Tel: 020-87317062 13048089691
Email: 852378519@qq.com
Country: China
ProdList: 153
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 94838
Advantage: 76

ZHIWE CHEMTECH CO LTD

Tel: 021-20221225 13917446399
Fax: QQ:115820162
Email: sales@zhiwe.net
Country: China
ProdList: 580
Advantage: 61

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32344
Advantage: 50

Spectrum Chemical Manufacturing Corp.

Tel: 021-021-021-67601398-809-809-809 15221380277
Fax: 021-57711696
Email: marketing_china@spectrumchemical.com
Country: China
ProdList: 9664
Advantage: 60

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 18521735133 18521732826;
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25014
Advantage: 65

Nanjing Sunlida Biological Technology Co., Ltd.

Tel: 025-57798810
Fax: 025-57019371
Email: sales@sunlidabio.com
Country: China
ProdList: 3750
Advantage: 55

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7854
Advantage: 58

Suzhou Pharmaceutical Technology co.,ltd

Tel: 051088771160，18051901298 19952779122
Fax: 0510-8877116
Email: 2013446823@qq.com
Country: China
ProdList: 52
Advantage: 61

GIHI CHEMICALS CO.,LTD

Tel: 0086-571-86217390
Fax: 0086-571-86217391
Email: Sales@gihichem.com
Country: China
ProdList: 861
Advantage: 58

Wuhan DKY Technology Co.,Ltd.

Tel: 27-81302488 18007166089
Fax: 027-81302088
Email: info@dkybpc.com
Country: China
ProdList: 2024
Advantage: 58

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 17994
Advantage: 56

Finetech Industry Limited

Tel: 027-87465837 19945049750
Fax: 027-8777-2287
Email: sales@finetechnology-ind.com
Country: China
ProdList: 9636
Advantage: 58

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2989
Advantage: 60

Hubei Jusheng Technology Co.,Ltd

Tel: 027-59599241 18871490274
Fax: 027-59599241
Email: 1400878000@qq.com
Country: China
ProdList: 9972
Advantage: 58

LETOPHARM LIMITED

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
ProdList: 2384
Advantage: 58

Chizhou Kailong Import and Export Trade Co., Ltd.

Tel
Fax: -
Email: xg01_gj@163.com
Country: China
ProdList: 9503
Advantage: 50

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51471
Advantage: 80

AN PharmaTech Co Ltd

Tel: 86(21)68097365
Fax: 86(21)33321566
Email: sales@anpharma.net
Country: China
ProdList: 4901
Advantage: 55

Pharmacodia (Beijing) Co.,Ltd

Tel: +86-400-851-9921
Fax: +86-10-82826195
Email: sales@pharmacodia.com
Country: China
ProdList: 2317
Advantage: 55

parabiochem

Tel: 025-83453382-8005
Fax: 025-83453382
Email: sale@parabiochem.com
Country: China
ProdList: 9604
Advantage: 55

Raw material medicin reagent co.,Ltd

Tel: 025-57798860
Email: sales@njromanme.com
Country: China
ProdList: 4534
Advantage: 58

Chengdu Dianchun Technology Co., Ltd

Tel: 400-1166-196 18502815961
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 14623
Advantage: 60

Shanghai SuperLan Chemcial Technique Centre

Tel: 021-2022843681 15618226720
Fax: +86-21-51601218
Email: chaolaichem@foxmail.com
Country: China
ProdList: 9038
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 4009686088
Email: 3193328036@qq.com
Country: China
ProdList: 29797
Advantage: 68

Chuzhou KeMail Chemical Technology Co., Ltd

Tel: 0550-5196001 15000891977
Fax: 0550-5196001
Email: wj520wjxby@126.com
Country: China
ProdList: 1836
Advantage: 55

Wuhan FengyaoTonghui Chemical Products Co., Ltd.

Tel: 027-87466105 15377573527
Email: 2678564200@qq.com
Country: China
ProdList: 17997
Advantage: 58

Shanghai He Huan Chemical Co., Ltd.

Tel: 021-60345187 13917602471
Fax: 021-60345187
Email: lzz841106@aliyun.com
Country: China
ProdList: 9908
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 400-400-400-9004166 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52712
Advantage: 58

Guangdong wengjiang Chemical Reagent Co., Ltd.

Tel: 0751-2815688 13927872512
Fax: 0751-8963795
Email: 3007421951@qq.com
Country: China
ProdList: 10067
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 13028896684
Email: sales@rrkchem.com
Country: China
ProdList: 55896
Advantage: 58

Guangzhou Tomums Life Science Co., Ltd.

Tel: 020-31155029 18902330969
Fax: 020-31155029
Email: sales@tomums.cn
Country: China
ProdList: 4698
Advantage: 58

SHANDONG ZHI SHANG CHEMICAL CO.LTD

Tel: +86 18953170293
Fax: +86 0531-67809011
Email: sales@sdzschem.com
Country: China
ProdList: 2931
Advantage: 58

Zhejiang J&C Biological Technology Co.,Limited

Tel: +1-2135480471 +1-2135480471
Email: sales@sarms4muscle.com
Country: China
ProdList: 10523
Advantage: 58

Finetech Industry Limited

Tel: +86-27-87465837 +8618971612321
Fax: 86 27 87772287
Email: info@finetechnology-ind.com
Country: China
ProdList: 9635
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: 0551-65418684 +8618949823763
Fax: 0086-551-65418684
Email: sales@tnjchem.com
Country: China
ProdList: 25363
Advantage: 58

Shandong Zhishang New Material Co., Ltd.

Tel: +8617653113209
Email: sales002@sdzschem.com
Country: China
ProdList: 3050
Advantage: 58

ShanDong Look Chemical Co.,Ltd.

Tel: +8617653113219
Email: sales01@sdlookchemical.com
Country: China
ProdList: 2739
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: 571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: CHINA
ProdList: 52867
Advantage: 58

AFINE CHEMICALS LIMITED

Tel: 0571-85134551
Fax: 008657185134895
Email: info@afinechem.com
Country: CHINA
ProdList: 15377
Advantage: 58

Dideu Industries Group Limited

Tel: +86-29-89586680 +86-15129568250
Email: 1026@dideu.com
Country: China
ProdList: 28608
Advantage: 58

Chemwill Asia Co.,Ltd.

Tel: 86-21-51086038
Fax: 86-21-51861608
Email: chemwill_asia@126.com
Country: CHINA
ProdList: 23931
Advantage: 58

Chongqing Chemdad Co., Ltd

Tel: +86-023-61398051 +8613650506873
Email: sales@chemdad.com
Country: China
ProdList: 39916
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11289
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49391
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: +86-29-87569265 +86-18612256290
Fax: 029-88380327
Email: 1056@dideu.com
Country: China
ProdList: 3335
Advantage: 58

Absin Bioscience Inc.

Tel: 021-38015121 15000105423
Email: chenjw@absin.cn
Country: China
ProdList: 24734
Advantage: 58

Nanjing shengyilai Chemical Co., Ltd

Tel: 19951936396
Email: 3158688292@qq.com
Country: China
ProdList: 4840
Advantage: 58

Shanghai Luofa Biochemical Technology Co., Ltd.

Tel: 021-51111890 15317326293
Email: sales@molnova.com
Country: China
ProdList: 4196
Advantage: 58

Less

View Lastest Price from Pergolide mesylate salt manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Pergolide mesylate salt 66104-23-2
Price: US $0.00-0.00/KG
Min. Order: 5mg
Purity: 99%
Supply Ability: 2000tons
Release date: 2019-12-27

Shaanxi Dideu Medichem Co. Ltd

Product: Pergolide mesylate salt 66104-23-2
Price: US $0.00-0.00/KG
Min. Order: 100g
Purity: 99%+
Supply Ability: 10 tons
Release date: 2019-12-27

Career Henan Chemical Co

Product: Pergolide mesylate salt 66104-23-2
Price: US $1.00/KG
Min. Order: 1G
Purity: 98%
Supply Ability: 100KG
Release date: 2018-08-20

66104-23-2, Pergolide mesylate saltRelated Search:

Methanol Methanesulfonic acid Kresoxim-methyl ISOMETHIOZIN Gatifloxacin mesylate Methyl cellulose Bensulfuron methyl Methylparaben Methyl acrylate Levofloxacin Methylate Pefloxacin mesylate Pergolide METSULFURON METHYL Pazufloxacin mesilate 8-CHLOROADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT Methyl 3-PHENYLPIPERIDINE alpha-methyl-1H-indole-3-ethylamine monomethanesulphonate

8BETA-[(METHYLTHIO)METHYL]-6-PROPYLERGOLINE MESYLATE SALT

8-BETA-[(METHYLTHIO)METHYL]-6-PROPYLERGOLINE MONOMETHANE SULFONATE

Pergolide mesylate EPIV

Pergolidemetylsulfonate

(8b)-8-[(Methylthio)methyl]-6-propylergoline Mesylate

Celance

Nopar

Permax

8-alpha-Methylthiomethyl-6-pro

8β-[(methylthio)methyl]-6-propylergoline methanesulfonate salt

Ergoline, 8-[(methylthio)methyl]-6-propyl-, (8b)-, monomethanesulfonate (9CI)

NSC 319773

Pergolide methanesulfonate

(8)-8-[(Methylthio)methyl]-6-propylergoline Mesylate

Pergolide methanesulfonate salt, 8β-[(Methylthio)methyl]-6-propylergoline methanesulfonate salt

Pergolin

Veceral

Pergolide methanesulfonate salt

8beta-[(Methylthio)methyl]-6-propylergoline methanesulfonate salt

beta-((Methylthio)Methyl)-6-propylergolineMethanesulfonate

Pergolide Mesylate, USP

Pergolide Mesylate (200 mg)

Ergoline, 8-[(methylthio)methyl]-6-propyl-, (8β)-, monomethanesulfonate (9CI)

(8beta)-8-[(methylthio)methyl]-6-propyl-Ergoline monomethanesulfonate (9CI)

8-beta-((methylthio)methyl)-6-propylergolinemethanesulfonate

8-beta-((methylthio)methyl)-6-propyl-ergolinmethanesulfonate(1:1)

ly127809

PERGOLIDE MESYLATE

PERGOLIDE MESYLATE SALT

MPE

Pergolide mesilate CRS

Pergolide mesylate salt, 98%, an antiparkinsonian agent which functions as a dopaminergic agonist

(6aR,9R,10aR)-9-[(Methylsulfanyl)methyl]-7-propyl- 4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline monomethanesulfonate

Pergolide mesylate salt USP/EP/BP

Pergolide Mesylate (LY127809)

Veterinary Drugs Pergolide mesylate salt

Pergolide Mesylate (1510845)

66104-23-2

C20H30N2O3S2

C21H18N3O2

C19H26N2SCH4O3S

LOCOID

API

Intermediates & Fine Chemicals

Neurochemicals

Pharmaceuticals