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ALPHA-APO-OXYTETRACYCLINE

Product Name
ALPHA-APO-OXYTETRACYCLINE
CAS No.
18751-99-0
Chemical Name
ALPHA-APO-OXYTETRACYCLINE
Synonyms
β-Apooxytetracycline;b-Apo-oxytetracycline;β-Apo-oxytetracycline;BETA-APO-OXYTETRACYCLINE;Apooxytetracycline, beta-;ALPHA-APO-OXYTETRACYCLINE;Oxytetracycline Impurity E;β-Apo-oxytetracycline, >85%;Oxytetracycline EP Impurity E;β-Apo-oxytetracycline, EvoPure?
CBNumber
CB9455892
Molecular Formula
C22H22N2O8
Formula Weight
442.42
MOL File
18751-99-0.mol
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ALPHA-APO-OXYTETRACYCLINE Property

Melting point:
200-204 °C
Boiling point:
742.4±60.0 °C(Predicted)
Density 
1.62±0.1 g/cm3(Predicted)
storage temp. 
Refrigerator, Under Inert Atmosphere
solubility 
Aqueous Base (Slightly), Methanol (Slightly, Heated, Sonicated)
form 
Powder
pka
1.62±0.58(Predicted)
color 
Yellow-brown to brown
Stability:
Unstable in basic solution
EPA Substance Registry System
1-Cyclohexene-1-carboxamide, 4-(1,3-dihydro-4,5-dihydroxy-9-methyl-3-oxonaphtho[2,3-c]furan-1-yl)-3-(dimethylamino)-2,5-dihydroxy-6-oxo- (18751-99-0)
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Safety

Hazard Codes 
Xn
Risk Statements 
63
Safety Statements 
45-36/37
HS Code 
29413020
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H361Suspected of damaging fertility or the unborn child

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P314Get medical advice/attention if you feel unwell.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
27099
Product name
β-Apooxytetracycline
Packaging
1mg
Price
$76
Updated
2024/03/01
Cayman Chemical
Product number
27099
Product name
β-Apooxytetracycline
Packaging
10mg
Price
$583
Updated
2024/03/01
Cayman Chemical
Product number
27099
Product name
β-Apooxytetracycline
Packaging
500μg
Price
$40
Updated
2024/03/01
Cayman Chemical
Product number
27099
Product name
β-Apooxytetracycline
Packaging
5mg
Price
$312
Updated
2024/03/01
Usbiological
Product number
002804
Product name
β-Apo-oxytetracycline
Packaging
1mg
Price
$340
Updated
2021/12/16
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ALPHA-APO-OXYTETRACYCLINE Chemical Properties,Usage,Production

Description

β-Apooxytetracycline is a potential impurity found in commercial preparations of oxytetracycline. β-Apooxytetracycline is a degradation product formed from oxytetracycline via acid hydrolysis. It has a relative potency of 0.1 compared with oxytetracycline for inhibiting the growth of aerobic sludge bacteria, an MIC50 value of 32 mg/L for tetracycline-sensitive strains of Pseudomonas, and MIC50 values of greater than 32 mg/L for tetracycline-sensitive strains of Agrobacterium, Moraxella, and Bacillus, as well as tetracycline-resistant strains of E. coli. β-Apooxytetracycline (10 mg/kg) is toxic to rats, decreasing body weight, disrupting blood cell counts, and inducing hepatocyte necrosis.

Chemical Properties

yellow-brown to brown powder

Uses

Oxytetracycline metabolite (absolute stereochemistry unknown)

Uses

β-Apooxytetracycline is a degradation product of oxytetracycline formed under acidic conditions. An initial dehydration to anhydrooxytetracycline then undergoes an internal cyclisation of the C5-OH to the C12 ketone. The resulting cleavage of the C12-C12a bond generates two isomers, α- and β-apooxytetracycline. β-apooxytetracycline is an important standard for monitoring oxytetracycline stability.

Uses

β-Apooxytetracycline is a degradation product of oxytetracycline formed under acidic conditions. After initial dehydration to anhydrooxytetracycline, it undergoes an internal cyclisation of the C5-OH to the C12 ketone. The resulting cleavage of the C12-C12a bond generates two isomers, α- and β-apooxytetracycline. β-Apooxytetracycline is an important standard for monitoring oxytetracycline stability.

ALPHA-APO-OXYTETRACYCLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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ALPHA-APO-OXYTETRACYCLINE Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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76
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11707
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57
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17770
Advantage
75
Clearsynth Labs Limited
Tel
+91-22-26355700
Fax
+91-22-26355701
Email
info@clearsynth.com
Country
India
ProdList
9679
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58
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18043
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Shanghai Kewel Chemical Co., Ltd.
Tel
021-64609169 18901607656
Fax
021-64609160
Email
greensnown@163.com
Country
China
ProdList
9906
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50
Alta Scientific Co., Ltd.
Tel
022-6537-8550 15522853686
Fax
022-2532-9655
Email
sales@altasci.com.cn
Country
China
ProdList
4511
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Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
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58
Shanghai Civic Chemical Technology Co., Ltd.
Tel
021-34053660
Fax
QQ:2881074831
Email
sale2@labgogo.com
Country
China
ProdList
2018
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58
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View Lastest Price from ALPHA-APO-OXYTETRACYCLINE manufacturers

Career Henan Chemical Co
Product
ALPHA-APO-OXYTETRACYCLINE 18751-99-0
Price
US $1.00/g
Min. Order
1g
Purity
≥98%
Supply Ability
g/kg/Ton
Release date
2019-12-25

18751-99-0, ALPHA-APO-OXYTETRACYCLINERelated Search:


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  • β-Apo-oxytetracycline, EvoPure?
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