ChemicalBook > CAS DataBase List > (S)-2,2-dimethyl-1-(5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)propan-1-one

(S)-2,2-dimethyl-1-(5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)propan-1-one

Product Name
(S)-2,2-dimethyl-1-(5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)propan-1-one
CAS No.
2049868-46-2
Chemical Name
(S)-2,2-dimethyl-1-(5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)propan-1-one
Synonyms
GSK'963;GSK'963;GSK963, 10 mM in DMSO;GSK-963;GSK 963;GSK'963;(S)-2,2-dimethyl-1-(5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)propan-1-one;1-Propanone, 1-[(5S)-4,5-dihydro-5-phenyl-1H-pyrazol-1-yl]-2,2-dimethyl-;GSK963,Inhibitor,RIP kinase,GSK 963,Receptor-interacting protein kinases,inhibit,GSK-963,RIPK
CBNumber
CB94656211
Molecular Formula
C14H18N2O
Formula Weight
230.31
MOL File
2049868-46-2.mol
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(S)-2,2-dimethyl-1-(5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)propan-1-one Property

Boiling point:
342.8±45.0 °C(Predicted)
Density 
1.06±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 25 mg/mL (108.55 mM; Need ultrasonic)
form 
Solid
pka
0.98±0.40(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML2376
Product name
GSK′963
Purity
≥98% (HPLC)
Packaging
5MG
Price
$125
Updated
2023/06/20
Sigma-Aldrich
Product number
SML2376
Product name
GSK′963
Purity
≥98% (HPLC)
Packaging
25MG
Price
$501
Updated
2023/06/20
TRC
Product number
G797815
Product name
GSK''963
Packaging
1mg
Price
$220
Updated
2021/12/16
DC Chemicals
Product number
023013
Product name
GSK963
Packaging
001
Price
$550
Updated
2021/12/16
DC Chemicals
Product number
023013
Product name
GSK963
Packaging
002
Price
$950
Updated
2021/12/16
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(S)-2,2-dimethyl-1-(5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)propan-1-one Chemical Properties,Usage,Production

Uses

GSK''963 is a novel highly potent and selective RIP1 inhibitor.

Biological Activity

GSKμ963 (GSKμ963A) is a brain-penetrant, highly potent and selective ATP site-targeting receptor-interacting protein 1 kinase (RIP1; RIPK1) inhibitor (IC50 = 0.8-8 nM with 50 μM ATP; IC50 >10 μM against RIPK2/3/5 and 335 other kinases) th at protects against TNFα/zVAD-induced necroptosis (EC50 = 1/4 nM in mouse L929/human U937 cultures) and blocks Y. pestis-induced death of murine fetal liver macrophages (1 μM). GSKμ963 prevents lethal hypothermia by acute sterile shock (2 mg/kg i.p. 15 min prior to TNFα/zVAD i.v.) and protects against acute neuronal death upon autologous blood intracerebral hemorrhage induction in mice in vivo (25 mg/kg/3 hr i.p.).

(S)-2,2-dimethyl-1-(5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)propan-1-one Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-2,2-dimethyl-1-(5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)propan-1-one Suppliers

China 40 United States 6 Global 46
Shanghai Lollane Biological Technology Co.,Ltd.
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021-52996696，15000506266 15000506266
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+86-21-52996696
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China
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BOC Sciences
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16314854226
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info@bocsci.com
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United States
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Tianjin Kailiqi Biotechnology Co., Ltd.
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Shanghai Rechem science Co., Ltd.
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TargetMol Chemicals Inc.
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marketing@targetmol.com
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InvivoChem
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DC Chemicals
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2049868-46-2, (S)-2,2-dimethyl-1-(5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)propan-1-oneRelated Search:


  • (S)-2,2-dimethyl-1-(5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)propan-1-one
  • GSK'963
  • GSK-963;GSK 963;GSK'963
  • 1-Propanone, 1-[(5S)-4,5-dihydro-5-phenyl-1H-pyrazol-1-yl]-2,2-dimethyl-
  • GSK963,Inhibitor,RIP kinase,GSK 963,Receptor-interacting protein kinases,inhibit,GSK-963,RIPK
  • GSK'963
  • GSK963, 10 mM in DMSO
  • 2049868-46-2