PA-6
- Product Name
- PA-6
- CAS No.
- 500715-03-7
- Chemical Name
- PA-6
- Synonyms
- PA-6 >=98% (HPLC);IK1 inhibitor PA-6 (PA-6);IK1 inhibitor PA-6, 10 mM in DMSO;1,5-Bis[4-[[imino(phenyl)methyl]amino]phenoxy]pentane;Benzenecarboximidamide, N,N''-[1,5-pentanediylbis(oxy-4,1-phenylene)]bis-;N-(4-{[5-(4-benzeneimidamidophenoxy)pentyl]oxy}phenyl)benzenecarboximidamide;IK1 inhibitor PA-6,IK1 inhibitor PA 6,Inhibitor,PA 6,Potassium Channel,PA6,IK-1 inhibitor PA-6,inhibit,KcsA,PA-6,IK1 inhibitor PA6
- CBNumber
- CB94662564
- Molecular Formula
- C31H32N4O2
- Formula Weight
- 492.61
- MOL File
- 500715-03-7.mol
PA-6 Property
- Boiling point:
- 648.1±65.0 °C(Predicted)
- Density
- 1.13±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 125 mg/mL (253.75 mM)
- pka
- 8.61±0.50(Predicted)
- form
- Solid
- color
- Off-white to light yellow
N-Bromosuccinimide Price
- Product number
- SML2185
- Product name
- PA-6
- Purity
- ≥98%(HPLC)
- Packaging
- 5mg
- Price
- $89.3
- Updated
- 2025/07/31
- Product number
- SML2185
- Product name
- PA-6
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $360
- Updated
- 2025/07/31
- Product number
- CS-0046342
- Product name
- IK1inhibitorPA-6
- Purity
- 98.23%
- Packaging
- 50mg
- Price
- $500
- Updated
- 2021/12/16
- Product number
- CS-0046342
- Product name
- IK1inhibitorPA-6
- Purity
- 98.23%
- Packaging
- 10mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- CS-0046342
- Product name
- IK1inhibitorPA-6
- Purity
- 98.23%
- Packaging
- 25mg
- Price
- $300
- Updated
- 2021/12/16
PA-6 Chemical Properties,Usage,Production
Uses
IK1 inhibitor PA-6 (PA-6), a pentamidine analogue, is a selective and potent IK1 (KIR2.x ion-channel-carried inward rectifier current) inhibitor, with IC50 values of 12-15 nM for human and mouse KIR2.x currents. IK1 inhibitor PA-6 (PA-6) elevates KIR2.1 protein expression and induces intracellular KIR2.1 accumulation. IK1 inhibitor PA-6 (PA-6) has the potential to treat atrial fibrillation and arrhythmia[1][2][3].
Biological Activity
PA-6 (Pentamidine-Analogue 6) is a selective and potent IK1 (inward rectifier potassium current) inhibitor th at terminates atrial fibrillation and does not cause ventricular arrhythmias in go at and dog models. PA-6 interacts with the cytoplasmic pore region of the KIR2.1 (KCNJ2) ion channel.
References
[1] Takanari H, et al. Efficient and specific cardiac IK? inhibition by a new pentamidine analogue. Cardiovasc Res. 2013 Jul 1;99(1):203-14. DOI:10.1093/cvr/cvt103
[2] Ji Y, et al. The inward rectifier current inhibitor PA-6 terminates atrial fibrillation and does not cause ventricular arrhythmias in goat and dog models. Br J Pharmacol. 2017 Aug;174(15):2576-2590. DOI:10.1111/bph.13869
[3] Ji Y, et al. PA-6 inhibits inward rectifier currents carried by V93I and D172N gain-of-function KIR2.1 channels, but increases channel protein expression. J Biomed Sci. 2017 Jul 15;24(1):44. DOI:10.1186/s12929-017-0352-x
PA-6 Preparation Products And Raw materials
Raw materials
Preparation Products
PA-6 Suppliers
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