OSMI-1
- Product Name
- OSMI-1
- CAS No.
- 1681056-61-0
- Chemical Name
- OSMI-1
- Synonyms
- OSMI-1;OSMI-1 ，S9835;OSMI-1 >=98% (HPLC);OSMI-1, 10 mM in DMSO;OSMI-1, O-GlcNAc transferase (OGT) inhibitor;(R)-N-(Furan-2-ylmethyl)-2-(2-methoxyphenyl)-2-(2-oxo-1,2-dihydroquinoline-6-sulfonamido)-N-(thiophen-2-ylmethyl)acetamide;Benzeneacetamide, α-[[(1,2-dihydro-2-oxo-6-quinolinyl)sulfonyl]amino]-N-(2-furanylmethyl)-2-methoxy-N-(2-thienylmethyl)-, (αR)-;cell-permeable,Inhibitor,OGT,Diacylglycerol acyltransferase,O-GlcNAcylation,toxicity,mammalian,inhibit,Acyltransferase,zebrafish,OSMI-1,acyl-CoA:cholesterol acyltransferase,Diglyceride acyltransferase,OSMI 1,OSMI1,O-GlcNAc,mono- acylglycerol acyltransferase,transferase
- CBNumber
- CB94666764
- Molecular Formula
- C28H25N3O6S2
- Formula Weight
- 563.64
- MOL File
- 1681056-61-0.mol
OSMI-1 Property
- Density
- 1.389±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMF: 25 mg/mL; DMF:PBS (pH 7.2) (1:5): 0.16 mg/mL; DMSO: 20 mg/mL
- form
- powder
- pka
- 8.77±0.20(Predicted)
- color
- white to beige
- InChIKey
- IYIGLWQQAMROOF-HHHXNRCGSA-N
- SMILES
- O=C(N1)C=CC2=C1C=CC(S(N[C@H](C3=C(OC)C=CC=C3)C(N(CC4=CC=CS4)CC5=CC=CO5)=O)(=O)=O)=C2
Safety
- WGK Germany
- WGK 3
- Storage Class
- 11 - Combustible Solids
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML1621
- Product name
- OSMI-1
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $195
- Updated
- 2026/03/19
- Product number
- SML1621
- Product name
- OSMI-1
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $779
- Updated
- 2026/03/19
- Product number
- 21894
- Product name
- OSMI-1
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 21894
- Product name
- OSMI-1
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $145
- Updated
- 2024/03/01
- Product number
- 21894
- Product name
- OSMI-1
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $261
- Updated
- 2024/03/01
OSMI-1 Chemical Properties,Usage,Production
Uses
OSMI 1 is a novel inhibitor of O-GlcNAc transferase (OGT).
Uses
OSMI-1 (OGT with a small molecule inhibitor) has been used in proximal ligation assay, Sox2 (SRY (sex determining region Y)-Box 2 ) dual luciferase reporter assay, Sox2 ELISA (enzyme linked immunosorbent assay) and other in vivo approaches, to study the O-Linked β-N-acetylglucosamine (O-GlcNAc) mediated regulation of self-renewal genes in cancer. It has also been used to study the Hippo pathway regulation mediated by O-GlcNAc transferase.
Definition
ChEBI: OSMI-1 is a sulfonamide resulting from the formal condensation of the sulfonic acid group of 2-oxo-1,2-dihydroquinoline-6-sulfonic acid with the primary amino group of (2R)-2-amino-N-(2-furylmethyl)-2-(2-methoxyphenyl)-N-(2-thienylmethyl)acetamide. OSMI-1 is a cell permeable inhibitor of O-linked beta-N-acetylglucosamine transferase (O-GlcNAc transferase, OGT). It has a role as an EC 2.* (transferase) inhibitor and an EC 2.4.1.255 (protein O-GlcNAc transferase) inhibitor. It is a sulfonamide, a member of quinolines, a member of furans, a member of thiophenes, an aromatic ether and a tertiary carboxamide.
Biochem/physiol Actions
OGT catalyses the attachment of N-acetylglucosamine moieties to a number proteins during post-translational modification. Inhibition of OGT activity might hinder the rate of viral replication in infections such as Herpes simplex viral disease.
in vivo
Mammalian and zebrafish toxicity profiles are strikingly similar, and zebrafish can usually serve as an intermediate step between cell-based evaluation and conventional animal testing. The zebrafish model is used to investigate OSM1-1 acute toxicity in vivo. The LC50 of OSM1-1 is 0.031 mg/mL (56 μM, 12 h) and 0.025 mg/mL (45 μM, 24 h) in zebrafish model[2].
OSMI-1 Preparation Products And Raw materials
Raw materials
Preparation Products
OSMI-1 Suppliers
- Tel
- 025-84699383-8003;025-846993838003-8003 18013301593;18013301590
- Fax
- 025-84699383-8003
- njduly@126.com
- Country
- China
- ProdList
- 3293
- Advantage
- 55
- Tel
- 400-400-164-7117 18317119277
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39999
- Advantage
- 60
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
- Country
- China
- ProdList
- 51395
- Advantage
- 80
- Tel
- 021-52996696，15000506266 15000506266
- Fax
- +86-21-52996696
- Country
- China
- ProdList
- 4827
- Advantage
- 55
- Tel
- 021-61350663 13052117465
- Fax
- 021-61350662
- sales@zehanbiopharma.com
- Country
- China
- ProdList
- 977
- Advantage
- 55
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9803
- Advantage
- 58
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 89689
- Advantage
- 60
- Tel
- 177-54423994 17754423994
- Fax
- QQ:2853530913
- 2853530910@QQ.com
- Country
- China
- ProdList
- 7999
- Advantage
- 62
- Tel
- 021-31433387 15618786686
- Fax
- QQ:1369748377
- sales@rechemscience.com
- Country
- China
- ProdList
- 2989
- Advantage
- 58
- Tel
- 0371-55900031 18137872243
- 3927209986@qq.com
- Country
- China
- ProdList
- 9999
- Advantage
- 55
View Lastest Price from OSMI-1 manufacturers
- Product
- OSMI-1 1681056-61-0
- Price
- US $2.00-5.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-20