OSMI-1
- Product Name
- OSMI-1
- CAS No.
- 1681056-61-0
- Chemical Name
- OSMI-1
- Synonyms
- OSMI-1;OSMI-1 >=98% (HPLC);(R)-N-(Furan-2-ylmethyl)-2-(2-methoxyphenyl)-2-(2-oxo-1,2-dihydroquinoline-6-sulfonamido)-N-(thiophen-2-ylmethyl)acetamide;Benzeneacetamide, α-[[(1,2-dihydro-2-oxo-6-quinolinyl)sulfonyl]amino]-N-(2-furanylmethyl)-2-methoxy-N-(2-thienylmethyl)-, (αR)-;cell-permeable,Inhibitor,OGT,Diacylglycerol acyltransferase,O-GlcNAcylation,toxicity,mammalian,inhibit,Acyltransferase,zebrafish,OSMI-1,acyl-CoA:cholesterol acyltransferase,Diglyceride acyltransferase,OSMI 1,OSMI1,O-GlcNAc,mono- acylglycerol acyltransferase,transferase
- CBNumber
- CB94666764
- Molecular Formula
- C28H25N3O6S2
- Formula Weight
- 563.64
- MOL File
- 1681056-61-0.mol
OSMI-1 Property
- Density
- 1.389±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMF: 25 mg/mL; DMF:PBS (pH 7.2) (1:5): 0.16 mg/mL; DMSO: 20 mg/mL
- form
- powder
- pka
- 8.77±0.20(Predicted)
- color
- white to beige
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML1621
- Product name
- OSMI-1
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $173
- Updated
- 2023/06/20
- Product number
- SML1621
- Product name
- OSMI-1
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $689
- Updated
- 2023/06/20
- Product number
- 21894
- Product name
- OSMI-1
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 21894
- Product name
- OSMI-1
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $145
- Updated
- 2024/03/01
- Product number
- 21894
- Product name
- OSMI-1
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $261
- Updated
- 2024/03/01
OSMI-1 Chemical Properties,Usage,Production
Uses
OSMI 1 is a novel inhibitor of O-GlcNAc transferase (OGT).
Uses
OSMI-1 (OGT with a small molecule inhibitor) has been used in proximal ligation assay, Sox2 (SRY (sex determining region Y)-Box 2 ) dual luciferase reporter assay, Sox2 ELISA (enzyme linked immunosorbent assay) and other in vivo approaches, to study the O-Linked β-N-acetylglucosamine (O-GlcNAc) mediated regulation of self-renewal genes in cancer. It has also been used to study the Hippo pathway regulation mediated by O-GlcNAc transferase.
Definition
ChEBI: OSMI-1 is a sulfonamide resulting from the formal condensation of the sulfonic acid group of 2-oxo-1,2-dihydroquinoline-6-sulfonic acid with the primary amino group of (2R)-2-amino-N-(2-furylmethyl)-2-(2-methoxyphenyl)-N-(2-thienylmethyl)acetamide. OSMI-1 is a cell permeable inhibitor of O-linked beta-N-acetylglucosamine transferase (O-GlcNAc transferase, OGT). It has a role as an EC 2.* (transferase) inhibitor and an EC 2.4.1.255 (protein O-GlcNAc transferase) inhibitor. It is a sulfonamide, a member of quinolines, a member of furans, a member of thiophenes, an aromatic ether and a tertiary carboxamide.
Biochem/physiol Actions
OGT catalyses the attachment of N-acetylglucosamine moieties to a number proteins during post-translational modification. Inhibition of OGT activity might hinder the rate of viral replication in infections such as Herpes simplex viral disease.
OSMI-1 Preparation Products And Raw materials
Raw materials
Preparation Products
OSMI-1 Suppliers
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- +1-781-999-5354 +1-00000000000
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- Country
- United States
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- +1-833-552-7181
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- Country
- United States
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