Use In vivo In vitro
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9-ING-41

Use In vivo In vitro
Product Name
9-ING-41
CAS No.
1034895-42-5
Chemical Name
9-ING-41
Synonyms
9-ING-41;9-ING-41 USP/EP/BP;3-(5-Fluoro-3-benzofuranyl)-4-(5-methyl-5H-1,3-dioxolo[4,5-f]indol-7-yl)-1H-pyrrole-2,5-dione;3-(5-fluorobenzofuran-3-yl)-4-(5-methyl-5H-[1,3]dioxolo[4,5-f]indol-7-yl)-1H-pyrrole-2,5-dione;1H-Pyrrole-2,5-dione, 3-(5-fluoro-3-benzofuranyl)-4-(5-methyl-5H-1,3-dioxolo[4,5-f]indol-7-yl)-;9-ING-41 3-?(5-?Fluorobenzofuran-?3-?yl)?-?4-?(5-?methyl-?5H- ?[1,?3]?dioxolo[4,?5-?f]?indol-?7-?yl)?pyrrole-?2,?5-?dione;cycle,GSK-3,cell,inhibit,9ING41,Apoptosis,Inhibitor,Glycogen synthase kinase 3,9 ING 41,arrest,Glycogen synthase kinase-3,anticancer,Autophagy,GSK-3β,activity
CBNumber
CB94667468
Molecular Formula
C22H13FN2O5
Formula Weight
404.35
MOL File
1034895-42-5.mol
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9-ING-41 Property

Boiling point:
649.5±55.0 °C(Predicted)
Density 
1.63±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 2 mg/ml; DMSO: 1 mg/ml; Ethanol: insol; PBS (pH 7.2): insol
form 
A solid
pka
7.23±0.60(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0063319
Product name
9-ING-41
Purity
99.32%
Packaging
5mg
Price
$120
Updated
2021/12/16
ChemScene
Product number
CS-0063319
Product name
9-ING-41
Purity
99.32%
Packaging
10mg
Price
$200
Updated
2021/12/16
ChemScene
Product number
CS-0063319
Product name
9-ING-41
Purity
99.32%
Packaging
25mg
Price
$420
Updated
2021/12/16
ChemScene
Product number
CS-0063319
Product name
9-ING-41
Purity
99.32%
Packaging
50mg
Price
$750
Updated
2021/12/16
ChemScene
Product number
CS-0063319
Product name
9-ING-41
Purity
99.32%
Packaging
100mg
Price
$1300
Updated
2021/12/16
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9-ING-41 Chemical Properties,Usage,Production

Use

9-ING-41 is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with antitumor activity. 9-ING-41 induces apoptosis and cell cycle arrest at prophase by targeting centrosomes and microtubule-bound GSK3β.

In vivo

9-ING-41 has single-agent antitumor activity in a mouse model of MCL. Mouse xenograft studies shows that the combination of clinically relevant doses of CPT-11 and 9-ING-41 lead to greater antitumor effect than is observed with either agent alone.

In vitro

9-ING-41, a clinically relevant small molecule GSK-3β inhibitor with broad spectrum pre-clinical antitumor activity, suppresses the growth of neuroblastoma cells.9-ING-41 induces apoptosis and cell cycle arrest at prophase by targeting centrosomes and microtubule-bound GSK3β.

Uses

3-(5-Fluoro-3-benzofuranyl)-4-(5-methyl-5H-1,3-dioxolo[4,5-f]indol-7-yl)-1H-pyrrole-2,5-dione induces apoptosis in human ovarian cells and also inhibits tumor growth in xenografted rat.

9-ING-41 Preparation Products And Raw materials

Raw materials

Preparation Products

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9-ING-41 Suppliers

China 32 United States 4 Global 36
Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Fax
028-81705658
Email
3003855609@qq.com
Country
China
ProdList
7892
Advantage
56
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9709
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58
Shanghai Rechem science Co., Ltd.
Tel
21-31433387 15618786686
Fax
QQ:1369748377
Email
sales@rechemscience.com
Country
China
ProdList
2991
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58
Shanghai Chaolan Chemical Technology Center
Tel
QQ:65489617 15618227136
Fax
21-5161 9052
Email
info@SuperLan-chem.com
Country
China
ProdList
9756
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58
Aikon International Limited
Tel
025-66113011 18112977050
Fax
(5)02557626880
Email
cb6@aikonchem.com
Country
China
ProdList
15495
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58
Twochem Co.Ltd.
Tel
021-58111628 15800915896
Fax
QQ 3285589261
Country
China
ProdList
1988
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58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
19892
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58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6393
Advantage
58
Dideu Industries Group Limited
Tel
+86-29-89586680 +86-15129568250
Email
1026@dideu.com
Country
China
ProdList
28302
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58
Shanghai Dongyang Biotechnology Co., Ltd.
Tel
0512-0512-13601744364 13601744364
Email
chemsharker@126.com
Country
China
ProdList
879
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58

1034895-42-5, 9-ING-41Related Search:


  • 9-ING-41
  • 9-ING-41 USP/EP/BP
  • 3-(5-Fluoro-3-benzofuranyl)-4-(5-methyl-5H-1,3-dioxolo[4,5-f]indol-7-yl)-1H-pyrrole-2,5-dione
  • 9-ING-41 3-?(5-?Fluorobenzofuran-?3-?yl)?-?4-?(5-?methyl-?5H- ?[1,?3]?dioxolo[4,?5-?f]?indol-?7-?yl)?pyrrole-?2,?5-?dione
  • 3-(5-fluorobenzofuran-3-yl)-4-(5-methyl-5H-[1,3]dioxolo[4,5-f]indol-7-yl)-1H-pyrrole-2,5-dione
  • cycle,GSK-3,cell,inhibit,9ING41,Apoptosis,Inhibitor,Glycogen synthase kinase 3,9 ING 41,arrest,Glycogen synthase kinase-3,anticancer,Autophagy,GSK-3β,activity
  • 1H-Pyrrole-2,5-dione, 3-(5-fluoro-3-benzofuranyl)-4-(5-methyl-5H-1,3-dioxolo[4,5-f]indol-7-yl)-
  • 1034895-42-5