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MN58b

Product Name
MN58b
CAS No.
203192-01-2
Chemical Name
MN58b
Synonyms
MN58b;MN58b,inhibit,Apoptosis,Inhibitor,MN-58b;1,1'-((Butane-1,4-diylbis(4,1-phenylene))bis(methylene))bis(4-(dimethylamino)pyridin-1-ium) bromide;1,1'-((Butane-1,4-diylbis(4,1-phenylene))bis(methylene))bis(4-(dimethylamino)pyridin-1-ium) bromide;Pyridinium, 1,?1'-?[1,?4-?butanediylbis(4,?1-?phenylenemethylene)?]?bis[4-?(dimethylamino)?-?, bromide (1:2);1-[[4-[4-[4-[[4-(dimethylamino)pyridin-1-ium-1-yl]methyl]phenyl]butyl]phenyl]methyl]-N,N-dimethylpyridin-1-ium-4-amine
CBNumber
CB94668218
Molecular Formula
C32H40BrN4+
Formula Weight
560.6
MOL File
203192-01-2.mol
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MN58b Property

storage temp. 
Store at -20°C
solubility 
DMSO:14.71(Max Conc. mg/mL);22.97(Max Conc. mM)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

DC Chemicals
Product number
DC21335
Product name
MN58b
Purity
>98%
Packaging
100mg
Price
$900
Updated
2021/12/16
DC Chemicals
Product number
DC21335
Product name
MN58b
Purity
>98%
Packaging
250mg
Price
$1600
Updated
2021/12/16
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MN58b Chemical Properties,Usage,Production

Biological Activity

MN58b is a selective choline kinase α (CHKα) inhibitor that inhibits phosphorylcholine synthesis.It reduces cell growth by inducing apoptosis and has antitumor activity.

in vitro

The IC 50 s of MN58b for parental and Gemcitabine-resistant Suit2 007 cells are 3.14 μM and 0.77 μM, respectively.
It has a marked effect on colony formation at 1 μM, and growth is completely abolished at 5 μM in all the cell lines.
It induces apoptosis and this response correlates with CHKα expression.

Cell Viability Assay

Cell Line: SK-PC-1 , Suit2 008, IMIM-PC2, and RWP-1 cells
Concentration: 1 μM, 5 μM
Incubation Time: 72 hours
Result: Inhibited ce lls growth.

Apoptosis Analysis

Cell Line: SK-PC-1, Suit2 008, IMIM-PC2, and RWP -1 cells
Concentration: 1 μM, 2 μM, 5 μM, 10 μM
Incubation Time: 24 and 48 hours
Result: Induced cell apoptosis.
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in vivo

MN58b (4 mg/kg; intraperitoneal injection; once a day; for 5 days; MF-1 nude mice) treatment significantly decreases phosphomonoesters in both HT29 and MDA-MB-231 xenografts. Phosphocholine levels are found to correlate with choline kinase activities.

Animal Model: MF-1 nude mice with HT29 or MDA-MB-231 cells
Dosage: 4 mg/kg
Administration: Intraperitoneal injection; once a day; for 5 days
Result : Phosphomonoesters decreased significantly.

target

Choline kinase α (CHKα)

MN58b Preparation Products And Raw materials

Raw materials

Preparation Products

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MN58b Suppliers

China 29 United States 6 Global 35
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
Advantage
58
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8012
Advantage
62
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
DC Chemicals
Tel
021-58447131 13564518121
Email
sales@dcchemicals.com
Country
China
ProdList
9409
Advantage
58
Changzhou Chenhong Biotechnology Co., Ltd.
Tel
0519-85788828 13775037613
Email
sales@chemrenpharm.com
Country
China
ProdList
3600
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd
Tel
15317229551
Fax
QQ:3607245178
Email
15151849396@163.com
Country
China
ProdList
999
Advantage
58
ShangHai ChuanQian Chemcial Technique Centre
Tel
15869524721
Email
3525679403@qq.com
Country
China
ProdList
4009
Advantage
58

203192-01-2, MN58bRelated Search:


  • MN58b
  • 1-[[4-[4-[4-[[4-(dimethylamino)pyridin-1-ium-1-yl]methyl]phenyl]butyl]phenyl]methyl]-N,N-dimethylpyridin-1-ium-4-amine
  • MN58b,inhibit,Apoptosis,Inhibitor,MN-58b
  • 1,1'-((Butane-1,4-diylbis(4,1-phenylene))bis(methylene))bis(4-(dimethylamino)pyridin-1-ium) bromide
  • Pyridinium, 1,?1'-?[1,?4-?butanediylbis(4,?1-?phenylenemethylene)?]?bis[4-?(dimethylamino)?-?, bromide (1:2)
  • 1,1'-((Butane-1,4-diylbis(4,1-phenylene))bis(methylene))bis(4-(dimethylamino)pyridin-1-ium) bromide
  • 203192-01-2