MN58b
- Product Name
- MN58b
- CAS No.
- 203192-01-2
- Chemical Name
- MN58b
- Synonyms
- MN58b;MN58b,inhibit,Apoptosis,Inhibitor,MN-58b;1,1'-((Butane-1,4-diylbis(4,1-phenylene))bis(methylene))bis(4-(dimethylamino)pyridin-1-ium) bromide;1,1'-((Butane-1,4-diylbis(4,1-phenylene))bis(methylene))bis(4-(dimethylamino)pyridin-1-ium) bromide;Pyridinium, 1,?1'-?[1,?4-?butanediylbis(4,?1-?phenylenemethylene)?]?bis[4-?(dimethylamino)?-?, bromide (1:2);1-[[4-[4-[4-[[4-(dimethylamino)pyridin-1-ium-1-yl]methyl]phenyl]butyl]phenyl]methyl]-N,N-dimethylpyridin-1-ium-4-amine
- CBNumber
- CB94668218
- Molecular Formula
- C32H40BrN4+
- Formula Weight
- 560.6
- MOL File
- 203192-01-2.mol
MN58b Property
- storage temp.
- Store at -20°C
- solubility
- DMSO:14.71(Max Conc. mg/mL);22.97(Max Conc. mM)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- DC21335
- Product name
- MN58b
- Purity
- >98%
- Packaging
- 100mg
- Price
- $900
- Updated
- 2021/12/16
- Product number
- DC21335
- Product name
- MN58b
- Purity
- >98%
- Packaging
- 250mg
- Price
- $1600
- Updated
- 2021/12/16
MN58b Chemical Properties,Usage,Production
Biological Activity
MN58b is a selective choline kinase α (CHKα) inhibitor that inhibits phosphorylcholine synthesis.It reduces cell growth by inducing apoptosis and has antitumor activity.
in vitro
The IC 50 s of MN58b for parental and Gemcitabine-resistant Suit2 007 cells are 3.14 μM and 0.77 μM, respectively.
It has a marked effect on colony formation at 1 μM, and growth is completely abolished at 5 μM in all the cell lines.
It induces apoptosis and this response correlates with CHKα expression.
Cell Viability Assay
| Cell Line: | SK-PC-1 , Suit2 008, IMIM-PC2, and RWP-1 cells |
| Concentration: | 1 μM, 5 μM |
| Incubation Time: | 72 hours |
| Result: | Inhibited ce lls growth. |
Apoptosis Analysis
| Cell Line: | SK-PC-1, Suit2 008, IMIM-PC2, and RWP -1 cells |
| Concentration: | 1 μM, 2 μM, 5 μM, 10 μM |
| Incubation Time: | 24 and 48 hours |
| Result: | Induced cell apoptosis. |
in vivo
MN58b (4 mg/kg; intraperitoneal injection; once a day; for 5 days; MF-1 nude mice) treatment significantly decreases phosphomonoesters in both HT29 and MDA-MB-231 xenografts. Phosphocholine levels are found to correlate with choline kinase activities.
| Animal Model: | MF-1 nude mice with HT29 or MDA-MB-231 cells |
| Dosage: | 4 mg/kg |
| Administration: | Intraperitoneal injection; once a day; for 5 days |
| Result : | Phosphomonoesters decreased significantly. |
target
Choline kinase α (CHKα)
MN58b Preparation Products And Raw materials
Raw materials
Preparation Products
MN58b Suppliers
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