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MN58b

Product Name
MN58b
CAS No.
203192-01-2
Chemical Name
MN58b
Synonyms
MN58b;MN58b,inhibit,Apoptosis,Inhibitor,MN-58b;1,1'-((Butane-1,4-diylbis(4,1-phenylene))bis(methylene))bis(4-(dimethylamino)pyridin-1-ium) bromide;1,1'-((Butane-1,4-diylbis(4,1-phenylene))bis(methylene))bis(4-(dimethylamino)pyridin-1-ium) bromide;Pyridinium, 1,?1'-?[1,?4-?butanediylbis(4,?1-?phenylenemethylene)?]?bis[4-?(dimethylamino)?-?, bromide (1:2);1-[[4-[4-[4-[[4-(dimethylamino)pyridin-1-ium-1-yl]methyl]phenyl]butyl]phenyl]methyl]-N,N-dimethylpyridin-1-ium-4-amine
CBNumber
CB94668218
Molecular Formula
C32H40BrN4+
Formula Weight
560.6
MOL File
203192-01-2.mol
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MN58b Property

storage temp. 
Store at -20°C
solubility 
DMSO:14.71(Max Conc. mg/mL);22.97(Max Conc. mM)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

DC Chemicals
Product number
DC21335
Product name
MN58b
Purity
>98%
Packaging
100mg
Price
$900
Updated
2021/12/16
DC Chemicals
Product number
DC21335
Product name
MN58b
Purity
>98%
Packaging
250mg
Price
$1600
Updated
2021/12/16
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MN58b Chemical Properties,Usage,Production

Biological Activity

MN58b is a selective choline kinase α (CHKα) inhibitor that inhibits phosphorylcholine synthesis.It reduces cell growth by inducing apoptosis and has antitumor activity.

in vitro

The IC 50 s of MN58b for parental and Gemcitabine-resistant Suit2 007 cells are 3.14 μM and 0.77 μM, respectively.
It has a marked effect on colony formation at 1 μM, and growth is completely abolished at 5 μM in all the cell lines.
It induces apoptosis and this response correlates with CHKα expression.

Cell Viability Assay

Cell Line: SK-PC-1 , Suit2 008, IMIM-PC2, and RWP-1 cells
Concentration: 1 μM, 5 μM
Incubation Time: 72 hours
Result: Inhibited ce lls growth.

Apoptosis Analysis

Cell Line: SK-PC-1, Suit2 008, IMIM-PC2, and RWP -1 cells
Concentration: 1 μM, 2 μM, 5 μM, 10 μM
Incubation Time: 24 and 48 hours
Result: Induced cell apoptosis.
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in vivo

MN58b (4 mg/kg; intraperitoneal injection; once a day; for 5 days; MF-1 nude mice) treatment significantly decreases phosphomonoesters in both HT29 and MDA-MB-231 xenografts. Phosphocholine levels are found to correlate with choline kinase activities.

Animal Model: MF-1 nude mice with HT29 or MDA-MB-231 cells
Dosage: 4 mg/kg
Administration: Intraperitoneal injection; once a day; for 5 days
Result : Phosphomonoesters decreased significantly.

target

Choline kinase α (CHKα)

MN58b Preparation Products And Raw materials

Raw materials

Preparation Products

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MN58b Suppliers

China 29 United States 6 Global 35
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
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InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
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58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38631
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
52924
Advantage
58
EBRATOR BIOCHEMICALS,INC.
Tel
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Fax
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Email
sales@ebtbio.com
Country
United States
ProdList
577
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58
MedChemExpress
Tel
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Fax
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Email
sales@medchemexpress.com
Country
United States
ProdList
6398
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58

203192-01-2, MN58bRelated Search:


  • MN58b
  • 1-[[4-[4-[4-[[4-(dimethylamino)pyridin-1-ium-1-yl]methyl]phenyl]butyl]phenyl]methyl]-N,N-dimethylpyridin-1-ium-4-amine
  • MN58b,inhibit,Apoptosis,Inhibitor,MN-58b
  • 1,1'-((Butane-1,4-diylbis(4,1-phenylene))bis(methylene))bis(4-(dimethylamino)pyridin-1-ium) bromide
  • Pyridinium, 1,?1'-?[1,?4-?butanediylbis(4,?1-?phenylenemethylene)?]?bis[4-?(dimethylamino)?-?, bromide (1:2)
  • 1,1'-((Butane-1,4-diylbis(4,1-phenylene))bis(methylene))bis(4-(dimethylamino)pyridin-1-ium) bromide
  • 203192-01-2