WNK inhibitor 12
- Product Name
- WNK inhibitor 12
- CAS No.
- 2123483-49-6
- Chemical Name
- WNK inhibitor 12
- Synonyms
- WNK-476;WNK 476;WNKIN12;WNK IN 12;WNK-IN-12;WNK-IN-11-d3;WNK inhibitor 12;WNK IN 11 d3,WNK-IN-11-d-3,WNKIN11d3
- CBNumber
- CB94668672
- Molecular Formula
- C21H21Cl2N5OS
- Formula Weight
- 462.39
- MOL File
- 2123483-49-6.mol
WNK inhibitor 12 Property
- storage temp.
- Store at -20°C
- form
- Solid
- color
- Off-white to light yellow
WNK inhibitor 12 Chemical Properties,Usage,Production
Biological Activity
WNK-IN-11 D3 is an orally active, selective and potent With-No-Lysine (WNK) kinase inhibitor. WNK-IN-11 D3 is effective at regulating cardiovascular homeostasis[1]. WNK-IN-11 D3 (1.5 mg/kg; p.o.) shows an improved rat PK profile, including lower clearance, improvement in absolute oral exposure, and a 2-fold improvement in oral bioavailability[1].WNK-IN-11 D3 (30 mg/kg; p.o.) shows significant reductions in systolic blood pressure (SBP) vs untreated mice[1].WNK-IN-11 D3 (0~100 mg/kg; p.o.) induces dose dependent diuresis, natriuresis, and kaliuresis, from 10 to 100 mg/kg[1].WNK-IN-11 D3 shows trends toward reduction of blood pressure, stroke volume, and total peripheral resistance, while increasing heart rate. WNK-IN-11 D3 shows efficacy in rodent models of hypertension and volume overload[1].
References
[1]. Yamada K, Levell J, Yoon T, et al. Optimization of Allosteric With-No-Lysine (WNK) Kinase Inhibitors and Efficacy in Rodent Hypertension Models. J Med Chem. 2017;60(16):7099-7107.
WNK inhibitor 12 Preparation Products And Raw materials
Raw materials
Preparation Products
WNK inhibitor 12 Suppliers
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32161
- Advantage
- 58