TFLLR-NH2(TFA)
- Product Name
- TFLLR-NH2(TFA)
- CAS No.
- 1313730-19-6
- Chemical Name
- TFLLR-NH2(TFA)
- Synonyms
- TFLLR-NH2(TFA);197794-83-5 (Thr1)-TRAP-5 amide;(S)-2-((S)-2-((2S,3R)-2-Amino-3-hydroxybutanamido)-3-phenylpropanamido)-N-((S)-1-(((S)-1-amino-5-guanidino-1-oxopentan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-4-methylpentanamide 2,2,2-trifluoroacetate
- CBNumber
- CB94713833
- Molecular Formula
- C33H54F3N9O8
- Formula Weight
- 761.85
- MOL File
- 1313730-19-6.mol
TFLLR-NH2(TFA) Property
- storage temp.
- Store at -20°C
- solubility
- Water: 100 mg/mL (131.26 mM); DMSO: 100 mg/mL (131.26 mM)
- form
- Solid
- color
- White to off-white
- Sequence
- H-Thr-Phe-Leu-Leu-Arg-NH2
N-Bromosuccinimide Price
- Product number
- CS-0058948
- Product name
- TFLLR-NH2(TFA)
- Purity
- 99.29%
- Packaging
- 1mg
- Price
- $216
- Updated
- 2021/12/16
- Product number
- CS-0058948
- Product name
- TFLLR-NH2(TFA)
- Purity
- 99.29%
- Packaging
- 5mg
- Price
- $864
- Updated
- 2021/12/16
TFLLR-NH2(TFA) Chemical Properties,Usage,Production
Biological Activity
TFLLR-NH2 (TFA) is a selective PAR1 agonist with an EC50 of 1.9 μM.
in vitro
PAR1 agonists stimulate concentration-dependent increases in [Ca 2+ ]i and in the proportions of neurones. The maximal increase in [Ca 2+ ] i above basal is detected in response to 10 μm TF-NH2 (peak 196.5±20.4 nM, n=25) when 50–80% of identified neurones responded. SW620 cells cultured in the supernatant of TFLLR-NH2-activated platelets upregulate E- cadherin expression and downregulate the vimentin expression. In the in vitro platelet culture system, a TFLLR-NH2 dose-dependent increase of secreted TGF-β1 is detected in the supernatant.
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in vivo
Injection of TF-NH2 into the rat paw stimulates a marked and sustained oedema. An NK1R antagonist and ablation of sensory nerves with capsaicin inhibit oedema by 44% at 1 h and completely by 5 h. In wild-type but not PAR1 ?/? mice, TF-NH2 stimulates Evans blue extravasation in the bladder, oesophagus, stomach, intestine and pancreas by 2–8 fold. Extravasation in the bladder, oesophagus and stomach is abolished by an NK1R antagonist. TFp-NH2 produces notable contraction at 3-50 μM and relaxation at 0.3-50 μM, in the absence of apamin. The concentration-response curve for TFp-NH2-induced contraction is remarkably shifted left, when the TFp- NH2-induced relaxation is blocked by apamin at 0.1 μM.
target
EC50: 1.9 μM (PAR1)
TFLLR-NH2(TFA) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from TFLLR-NH2(TFA) manufacturers
- Product
- TFLLR-NH2(TFA) 1313730-19-6
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-02-13