Mitochonic acid 5
- Product Name
- Mitochonic acid 5
- CAS No.
- 1354707-41-7
- Chemical Name
- Mitochonic acid 5
- Synonyms
- Mitochonic acid;Mitochonic acid 5;Mitochonic acid 5(MA-5);Mitochonic acid 5, 10 mM in DMSO;α-[2-(2,4-Difluorophenyl)-2-oxoethyl]-1H-indole-3-acetic Acid;1H-Indole-3-acetic acid, α-[2-(2,4-difluorophenyl)-2-oxoethyl]-;MA5,Inhibitor,Mitochonic acid5,Mitochonic acid-5,Mitochondrial Metabolism,Mitochonic acid 5,inhibit,MA 5
- CBNumber
- CB94718636
- Molecular Formula
- C18H13F2NO3
- Formula Weight
- 329.3
- MOL File
- 1354707-41-7.mol
Mitochonic acid 5 Property
- Boiling point:
- 573.3±50.0 °C(Predicted)
- Density
- 1.426±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:106.66(Max Conc. mg/mL);323.9(Max Conc. mM)
- form
- A solid
- pka
- 4.52±0.37(Predicted)
- color
- Light yellow to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D447895
- Product name
- α-[2-(2,4-Difluorophenyl)-2-oxoethyl]-1H-indole-3-aceticAcid
- Packaging
- 2.5mg
- Price
- $220
- Updated
- 2021/12/16
- Product number
- CS-0043233
- Product name
- Mitochonicacid5
- Purity
- 99.37%
- Packaging
- 5mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- Axon3197
- Product name
- Mitochonicacid5-MA-5
- Purity
- 98%
- Packaging
- 2x5mg
- Price
- $154
- Updated
- 2021/12/16
- Product number
- CS-0043233
- Product name
- Mitochonicacid5
- Purity
- 99.37%
- Packaging
- 10mg
- Price
- $230
- Updated
- 2021/12/16
- Product number
- CS-0043233
- Product name
- Mitochonicacid5
- Purity
- 99.37%
- Packaging
- 25mg
- Price
- $460
- Updated
- 2021/12/16
Mitochonic acid 5 Chemical Properties,Usage,Production
Uses
α-[2-(2,4-Difluorophenyl)-2-oxoethyl]-1H-indole-3-acetic Acid, is a derivative of the plant hormone indole-3-acetic acid, improves survival of fibroblasts from patients with mitochondrial diseases.
Biological Activity
Mitochonic Acid 5 is a potent enhancer of mitochondrial ATP production th at significantly increased the cellular ATP level in Hep3B human hepatocellular carcinoma cells. Mitochonic Acid 5 improves the survival of fibroblasts from patients with mitochondrial diseases. It appears th at mitochonic Acid 5 facilitates ATP synthase oligomerization and supercomplex formation with mitofilin/Mic60.
in vivo
Administration of Mitochonic acid 5 (MA-5) to an ischemia-reperfusion injury model and a cisplatin-induced nephropathy model improved renal function. To examine the tissue-protective effect of Mitochonic acid 5, the oral bioavailability is examined. Oral administration of Mitochonic acid 5 increases the plasma concentration in a dose-response manner at the peak time of 1 hour[1].
Mitochonic acid 5 Preparation Products And Raw materials
Raw materials
Preparation Products
Mitochonic acid 5 Suppliers
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32435
- Advantage
- 58
- Tel
- +1-708-310-1919 +1-13798911105
- Fax
- 708-557-7486
- sales@invivochem.cn
- Country
- United States
- ProdList
- 6391
- Advantage
- 58
- Tel
- tp@aladdinsci.com
- Country
- United States
- ProdList
- 57505
- Advantage
- 58
- Tel
- +1-781-999-5354;
- support@targetmol.com
- Country
- United States
- ProdList
- 39035
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@ebtbio.com
- Country
- United States
- ProdList
- 577
- Advantage
- 58
- Tel
- --
- Fax
- --
- cayman@caymanchem.com
- Country
- United States
- ProdList
- 6213
- Advantage
- 81
- Tel
- --
- Fax
- --
- sales@medchemexpress.com
- Country
- United States
- ProdList
- 6398
- Advantage
- 58