7-Benzyloxy-4-chloro-6-methoxyquinazoline

Product Name: 7-Benzyloxy-4-chloro-6-methoxyquinazoline
CAS No.: 162364-72-9
Chemical Name: 7-Benzyloxy-4-chloro-6-methoxyquinazoline
Synonyms: 7-Benzyloxy-4-chloro-6-methoxyquinazoli;162364-72-9;7-Benzyloxy-4-chloro-6-methoxy-quizoline;4-Chloro-6-methoxy-7-benzyloxyquinazoline;7-BENZYLOXY-4-CHLORO-6-METHOXY-QUINAZOLINE;4-chloro-7-benzyloxy -6-Methoxyquinazoline;7-(Benzyloxy)-4-chloro-6-methoxyquinazoline 98%;4-chloro-6-methoxy-7-(phenylmethoxy)quinazoline;Quinazoline, 4-chloro-6-Methoxy-7-(phenylMethoxy)-;Quinazoline,4-chloro-6-methoxy-7-(phenylmethoxy)-,98%
CBNumber: CB9474149
Molecular Formula: C16H13ClN2O2
Formula Weight: 300.74
MOL File: 162364-72-9.mol

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7-Benzyloxy-4-chloro-6-methoxyquinazoline Property

Boiling point:: 452.1±40.0 °C(Predicted)
Density: 1.303±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 0.72±0.30(Predicted)
Appearance: Off-white to yellow Solid

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Safety

HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B416215
Product name: 7-(Benzyloxy)-4-chloro-6-methoxyquinazoline
Packaging: 10mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B416215
Product name: 7-(Benzyloxy)-4-chloro-6-methoxyquinazoline
Packaging: 50mg
Price: $60
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H08-5-74
Product name: 7-(Benzyloxy)-4-chloro-6-methoxyquinazoline
Packaging: 250mg
Price: $125
Updated: 2021/12/16

Apolloscientific

Product number: OR17604
Product name: 7-(Benzyloxy)-4-chloro-6-methoxyquinazoline
Purity: 98%
Packaging: 5g
Price: $83
Updated: 2021/12/16

Matrix Scientific

Product number: 072638
Product name: 7-Benzyloxy-4-chloro-6-methoxyquinazoline
Purity: 95+%
Packaging: 250mg
Price: $310
Updated: 2021/12/16

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7-Benzyloxy-4-chloro-6-methoxyquinazoline Chemical Properties,Usage,Production

Synthesis

179688-01-8

162364-72-9

General procedure for the synthesis of 7-benzyloxy-4-chloro-6-methoxyquinazoline from 6-methoxy-7-(benzyloxy)quinazolin-4(3H)-one: 2.1 g of 6-methoxy-7-(benzyloxy)quinazolin-4(3H)-one (Compound IV), 9.1 g of phosphorus trichloride, and 60 mL of ethylene dichloride were mixed, and the reaction was carried out by refluxing the reaction for 1 hour at 85 °C. Upon completion of the reaction, the excess phosphorous trichloride was removed by rotary evaporation. Ice water was added to the residue and the mixture was extracted with dichloromethane. The organic phases were combined, washed with saturated sodium chloride solution and dried over anhydrous magnesium sulfate. The desiccant was removed by filtration and the filtrate was concentrated under reduced pressure and purified by silica gel column chromatography, using a gradient elution of n-hexane to ethyl acetate in 5:1, 3:1 and 1:1 volume ratios, respectively. The eluted fractions at a volume ratio of hexane to ethyl acetate of 1:1 were collected to give 2.1 g of off-white solid (7-benzyloxy-4-chloro-6-methoxyquinazoline, compound 5) in 93.9% yield.

References

[1] Patent: CN105541736, 2016, A. Location in patent: Paragraph 0044; 0049
[2] European Journal of Medicinal Chemistry, 2017, vol. 125, p. 245 - 254
[3] Patent: CN105884699, 2016, A. Location in patent: Paragraph 0062; 0063
[4] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 18, p. 5342 - 5346

7-Benzyloxy-4-chloro-6-methoxyquinazoline Preparation Products And Raw materials

Raw materials

Preparation Products

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7-Benzyloxy-4-chloro-6-methoxyquinazoline Suppliers

China 132 India 1 United Kingdom 2 United States 12 Global 147

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View Lastest Price from 7-Benzyloxy-4-chloro-6-methoxyquinazoline manufacturers

Career Henan Chemical Co

Product: 7-Benzyloxy-4-chloro-6-methoxyquinazoline 162364-72-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: G/KG/T
Release date: 2019-12-23

162364-72-9, 7-Benzyloxy-4-chloro-6-methoxyquinazolineRelated Search:

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7-Benzyloxy-4-chloro-6-methoxyquinazoline ISO 9001：2015 REACH

7-Benzyloxy-4-chloro-6-methoxyquinazoli

162364-72-9