POLYOXIN A Property

alpha 

D20 -30°

Density 

1.748±0.06 g/cm3(Predicted)

pka

3.07±0.20(Predicted)

Safety

Toxicity

Acute oral LD₅₀>20000mg/kg in rats and mice, acute transdermal LD₅₀>12000mg/kg in rats, acute inhalation LD_{50 in rats} >10mg/L. No irritation to rabbit eyes and skin. No carcinogenic, teratogenic or mutagenic effects were found in animal experiments. Carp LC₅₀>40mg/L (48h), Daphnia LC₅₀>40mg/L (3h). Low toxicity to bees, LD₅₀>1000mg/bee.

Hazard and Precautionary Statements (GHS)

POLYOXIN A Chemical Properties,Usage,Production

Chemical Properties

Colorless needle crystal, m.p.180°C or amorphous crystal, m.p.160°C (decomposition). POLYOXIN A is easily soluble in water, but insoluble in organic solvents such as methanol, ethanol, acetone, chloroform, benzene and ether. It is stable to ultraviolet light, acidic solution and neutral solution, unstable to alkaline solution, and stable for more than 3 years when stored at room temperature. The appearance of the industrial product is light brown powder or taupe powder.

Uses

POLYOXIN A is a broad-spectrum antibiotic fungicide with systemic conduction. It is mainly used to control wheat powdery mildew, ginseng black spot, tobacco red spot, cucumber downy mildew, melon wilt, rice sheath blight, apple spotted leaf spot, strawberry and grape gray mold, forest sheath wilt, etc.

Synthesis

POLYOXIN A can be obtained by the method: connect the sand pipe to the slope (aseptic operation) and cultivate it at a constant temperature of 28°C. After the spores grow and mature, connect the slope spores to the slope again. After constant temperature cultivation, it will be the slope for production; tank), fermentation (fermentation tank), acidification, concentration, spray drying and crushing.