COLISTIN
Neurotoxicity and Nephrotoxicity- Product Name
- COLISTIN
- CAS No.
- 1066-17-7
- Chemical Name
- COLISTIN
- Synonyms
- COLISTIN;kangdisu;totazina;colimycin;colomycin;Aids033059;coly-mycin;colymysins;kolimitsin;Aids-033059
- CBNumber
- CB0169873
- Molecular Formula
- C52H98N16O13
- Formula Weight
- 1155.43
- MOL File
- 1066-17-7.mol
COLISTIN Property
- Boiling point:
- 807.67°C (rough estimate)
- Density
- 1.1050 (rough estimate)
- refractive index
- 1.6700 (estimate)
- storage temp.
- Store at -20°C
- solubility
- PBS (pH 7.2): 10 mg/ml
- CAS DataBase Reference
- 1066-17-7
Safety
- RIDADR
- 3249
- HazardClass
- 6.1(b)
- PackingGroup
- III
- Hazardous Substances Data
- 1066-17-7(Hazardous Substances Data)
- Toxicity
- cat,LDLo,subcutaneous,250mg/kg (250mg/kg),GASTROINTESTINAL: NAUSEA OR VOMITINGBEHAVIORAL: ATAXIABEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY),Antibiotiki. Vol. 5(4), Pg. 10, 1960.
N-Bromosuccinimide Price
- Product number
- Y0001999
- Product name
- Colistin for system suitability
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- 10 mg
- Price
- $155
- Updated
- 2025/07/31
- Product number
- Y0001999
- Product name
- Colistin for system suitability
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- y0001999
- Price
- $152
- Updated
- 2024/03/01
- Product number
- 23487
- Product name
- Colistin
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $89
- Updated
- 2021/12/16
- Product number
- 23487
- Product name
- Colistin
- Purity
- ≥95%
- Packaging
- 100mg
- Price
- $285
- Updated
- 2021/12/16
- Product number
- 9632AJ
- Product name
- Colistin
- Packaging
- 100mg
- Price
- $484
- Updated
- 2021/12/16
COLISTIN Chemical Properties,Usage,Production
Neurotoxicity and Nephrotoxicity
Colistin is an antibiotic which is being used more commonly now than when it was introduced because of its activity against multiresistant Gram-negative bacteria, especially Acinetobacter baumanii and Enterobacteriaceae producing extended spectrum β-lactamases. It had a bad reputation due to reports of neurotoxicity and nephrotoxicity. Recent studies have shown lower rates of nephrotoxicity than previously reported. However, in one of these reports, 7/42 patients with high serum creatinine values prior to colistin treatment developed renal failure.
Chemical Properties
White crystalline powder. Soluble in water, slightly soluble in ethanol or methanol, insoluble in acetone or ether. Hygroscopic, odorless, bitter.
Uses
Polymyxin E (colistin) is a complex of closely related cyclic peptides E1 and E2, with additional minor analogues. Polymyxin E is produced by Bacillus polymyxa var. colistinus, and is a highly basic, atypical cyclic peptide which incorporates the unusual amino acid, diaminobutyric acid. Head-to-tail coupling of lysine completes the macrocycle. Balancing the polar cyclic peptide is a hydrophobic tail with short chain fatty acids. Polymyxin E is a broad spectrum antibiotic active against Gram negative bacteria. The mechanism of action involves disruption of the bacterial outer membrane by a detergent-like effect.
brand name
Coly-Mycin (Monarch).
in vivo
Colistin (Polymyxin E) (16 mg/kg/day, i.p.) shows the enrichment of cell cycle arrest genes and suggests that injury or cellular stress caused by colistin is acting through p53 to inhibit cell cycle progression[1].
Colistin (16 mg/kg/day, i.p.) has elevated blood urea nitrogen (BUN), creatinine, and pathologic evidence of acute tubular necrosis and apoptosis[1].
| Animal Model: | C57/BL6 mice[1] |
| Dosage: | 16 mg/kg/day |
| Administration: | 16 mg/kg/day, i.p. |
| Result: | Detected apoptosis, necrosis PCNA staining in mice. |
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View Lastest Price from COLISTIN manufacturers
- Product
- Colistin 1066-17-7
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 1000kg
- Release date
- 2025-04-24
- Product
- amoxicillin 1066-17-7
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-01
- Product
- COLISTIN 1066-17-7
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-01-09