COLISTIN
Neurotoxicity and Nephrotoxicity- Product Name
- COLISTIN
- CAS No.
- 1066-17-7
- Chemical Name
- COLISTIN
- Synonyms
- COLISTIN;kangdisu;totazina;colimycin;colomycin;Aids033059;coly-mycin;colymysins;kolimitsin;Aids-033059
- CBNumber
- CB0169873
- Molecular Formula
- C52H98N16O13
- Formula Weight
- 1155.43
- MOL File
- 1066-17-7.mol
COLISTIN Property
- Boiling point:
- 807.67°C (rough estimate)
- Density
- 1.1050 (rough estimate)
- refractive index
- 1.6700 (estimate)
- storage temp.
- Store at -20°C
- solubility
- PBS (pH 7.2): 10 mg/ml
- CAS DataBase Reference
- 1066-17-7
Safety
- RIDADR
- 3249
- HazardClass
- 6.1(b)
- PackingGroup
- III
- Hazardous Substances Data
- 1066-17-7(Hazardous Substances Data)
- Toxicity
- cat,LDLo,subcutaneous,250mg/kg (250mg/kg),GASTROINTESTINAL: NAUSEA OR VOMITINGBEHAVIORAL: ATAXIABEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY),Antibiotiki. Vol. 5(4), Pg. 10, 1960.
N-Bromosuccinimide Price
- Product number
- Y0001999
- Product name
- Colistin for system suitability
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- y0001999
- Price
- $152
- Updated
- 2024/03/01
- Product number
- 23487
- Product name
- Colistin
- Purity
- ≥95%
- Packaging
- 100mg
- Price
- $285
- Updated
- 2021/12/16
- Product number
- 23487
- Product name
- Colistin
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $89
- Updated
- 2021/12/16
- Product number
- 9632AJ
- Product name
- Colistin
- Packaging
- 100mg
- Price
- $484
- Updated
- 2021/12/16
- Product number
- 9632AJ
- Product name
- Colistin
- Packaging
- 25mg
- Price
- $220
- Updated
- 2021/12/16
COLISTIN Chemical Properties,Usage,Production
Neurotoxicity and Nephrotoxicity
Colistin is an antibiotic which is being used more commonly now than when it was introduced because of its activity against multiresistant Gram-negative bacteria, especially Acinetobacter baumanii and Enterobacteriaceae producing extended spectrum β-lactamases. It had a bad reputation due to reports of neurotoxicity and nephrotoxicity. Recent studies have shown lower rates of nephrotoxicity than previously reported. However, in one of these reports, 7/42 patients with high serum creatinine values prior to colistin treatment developed renal failure.
Uses
Polymyxin E (colistin) is a complex of closely related cyclic peptides E1 and E2, with additional minor analogues. Polymyxin E is produced by Bacillus polymyxa var. colistinus, and is a highly basic, atypical cyclic peptide which incorporates the unusual amino acid, diaminobutyric acid. Head-to-tail coupling of lysine completes the macrocycle. Balancing the polar cyclic peptide is a hydrophobic tail with short chain fatty acids. Polymyxin E is a broad spectrum antibiotic active against Gram negative bacteria. The mechanism of action involves disruption of the bacterial outer membrane by a detergent-like effect.
brand name
Coly-Mycin (Monarch).
COLISTIN Suppliers
View Lastest Price from COLISTIN manufacturers
- Product
- COLISTIN 1066-17-7
- Price
- US $0.80/kg
- Min. Order
- 1kg
- Purity
- 99.95%HTCL
- Supply Ability
- 10Tons
- Release date
- 2023-04-11
- Product
- amoxicillin 1066-17-7
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-09-08
- Product
- amoxicillin 1066-17-7
- Price
- US $1.00/PCS
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2021-01-18