COLISTIN

ChemicalBook > CAS DataBase List > COLISTIN

Neurotoxicity and Nephrotoxicity

Product Name: COLISTIN
CAS No.: 1066-17-7
Chemical Name: COLISTIN
Synonyms: COLISTIN;kangdisu;totazina;colimycin;colomycin;Aids033059;coly-mycin;colymysins;kolimitsin;Aids-033059
CBNumber: CB0169873
Molecular Formula: C52H98N16O13
Formula Weight: 1155.43
MOL File: 1066-17-7.mol

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COLISTIN Property

Boiling point:: 807.67°C (rough estimate)
Density: 1.1050 (rough estimate)
refractive index: 1.6700 (estimate)
storage temp.: Store at -20°C
solubility: PBS (pH 7.2): 10 mg/ml
CAS DataBase Reference: 1066-17-7

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Safety

RIDADR: 3249
HazardClass: 6.1(b)
PackingGroup: III
Hazardous Substances Data: 1066-17-7(Hazardous Substances Data)
Toxicity: cat,LDLo,subcutaneous,250mg/kg (250mg/kg),GASTROINTESTINAL: NAUSEA OR VOMITINGBEHAVIORAL: ATAXIABEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY),Antibiotiki. Vol. 5(4), Pg. 10, 1960.

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0001999
Product name: Colistin for system suitability
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: y0001999
Price: $152
Updated: 2024/03/01

Cayman Chemical

Product number: 23487
Product name: Colistin
Purity: ≥95%
Packaging: 100mg
Price: $285
Updated: 2021/12/16

Cayman Chemical

Product number: 23487
Product name: Colistin
Purity: ≥95%
Packaging: 25mg
Price: $89
Updated: 2021/12/16

AK Scientific

Product number: 9632AJ
Product name: Colistin
Packaging: 100mg
Price: $484
Updated: 2021/12/16

AK Scientific

Product number: 9632AJ
Product name: Colistin
Packaging: 25mg
Price: $220
Updated: 2021/12/16

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COLISTIN Chemical Properties,Usage,Production

Neurotoxicity and Nephrotoxicity

Colistin is an antibiotic which is being used more commonly now than when it was introduced because of its activity against multiresistant Gram-negative bacteria, especially Acinetobacter baumanii and Enterobacteriaceae producing extended spectrum β-lactamases. It had a bad reputation due to reports of neurotoxicity and nephrotoxicity. Recent studies have shown lower rates of nephrotoxicity than previously reported. However, in one of these reports, 7/42 patients with high serum creatinine values prior to colistin treatment developed renal failure.

Uses

Polymyxin E (colistin) is a complex of closely related cyclic peptides E1 and E2, with additional minor analogues. Polymyxin E is produced by Bacillus polymyxa var. colistinus, and is a highly basic, atypical cyclic peptide which incorporates the unusual amino acid, diaminobutyric acid. Head-to-tail coupling of lysine completes the macrocycle. Balancing the polar cyclic peptide is a hydrophobic tail with short chain fatty acids. Polymyxin E is a broad spectrum antibiotic active against Gram negative bacteria. The mechanism of action involves disruption of the bacterial outer membrane by a detergent-like effect.

brand name

Coly-Mycin (Monarch).

COLISTIN Preparation Products And Raw materials

Raw materials

Colistin sulfate

Preparation Products

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View Lastest Price from COLISTIN manufacturers

Hebei Weibang Biotechnology Co., Ltd

Product: amoxicillin 1066-17-7
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-01

Hebei Mojin Biotechnology Co., Ltd

Product: amoxicillin 1066-17-7
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-09-08

Career Henan Chemical Co

Product: COLISTIN 1066-17-7
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-01-09

1066-17-7, COLISTINRelated Search:

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COLISTIN

colimycin

1264-72-8 (Sulfate)

Aids033059

Aids-033059

Colistin, ColiMycin M, BelcoMycin, ColyMycin, Torazin

PolyMyxin E coMplex

[(2S)-4-amino-1-[[(2S,3R)-1-[[(2S)-4-amino-1-oxo-1-[[(1S,4S,7R,10S,13S,16S,19S)-4,13,16-tris(2-aminoethyl)-19-[(1R)-1-hydroxyethyl]-10-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-7-(phenylmethyl)-3,6

Polymyxin E1 sulfate

Polyoxin W.P.

colisticina

colomycin

coly-mycin

colymysins

kangdisu

kolimitsin

totazina

Colistin for system suitability

COLISTIN USP/EP/BP

Polymyxin E1 (Colistin A)

1066-17-7

C58H90N16O8