ChemicalBook > CAS DataBase List > SC-43

SC-43

Product Name
SC-43
CAS No.
1400989-25-4
Chemical Name
SC-43
Synonyms
SC-43;1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3-(4-cyanophenoxy)phenyl)urea;Urea, N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-[3-(4-cyanophenoxy)phenyl]-;antiproliferative,Inhibitor,SC-43,SHP-1,PTPN6,Phosphatase,Apoptosis,caspase-3,SC 43,anti-fibrotic,p-STAT3,anticancer,orally,SC43,PARP,STAT,inhibit
CBNumber
CB94801426
Molecular Formula
C21H13ClF3N3O2
Formula Weight
431.8
MOL File
1400989-25-4.mol
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SC-43 Property

Boiling point:
462.0±45.0 °C(Predicted)
Density 
1.46±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: 250 mg/mL (578.97 mM)
form 
A solid
pka
12.92±0.70(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0132863
Product name
SC-43
Purity
98.61%
Packaging
5mg
Price
$250
Updated
2021/12/16
ChemScene
Product number
CS-0132863
Product name
SC-43
Purity
98.61%
Packaging
10mg
Price
$350
Updated
2021/12/16
ChemScene
Product number
CS-0132863
Product name
SC-43
Purity
98.61%
Packaging
25mg
Price
$650
Updated
2021/12/16
Ambeed
Product number
A300602
Product name
SC-43
Purity
98+%
Packaging
250mg
Price
$610
Updated
2021/12/16
Ambeed
Product number
A300602
Product name
SC-43
Purity
98+%
Packaging
100mg
Price
$310
Updated
2021/12/16
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SC-43 Chemical Properties,Usage,Production

Biological Activity

SC-43 is a derivative of sorafenib, an agonist of Src-homology protein tyrosine phosphatase-1 (SHP-1/PTPN6), which reduces liver fibrosis. SC-43 can reduce p-STAT3 and induce apoptosis, and has antitumor activity.

in vitro

SC-43 (0-10 μM; 24-72 hours; HuCCT-1, KKU-100, and CGCCA cells) treatment reveals the anti-proliferative effects in cholangiocarcinoma (CCA) cell lines in a dose-dependent manner after treating 24, 48 and 72 hours respectively.  
Its treatment shows increased sub-G1 cells and G2-M arrest, indicating SC-43 induced differential apoptotic effects in these cell lines.  
Its (0-10 μM; 24 hours; HuCCT-1, KKU-100, and CGCCA cells) treatment demonstrates significant increase in cleaved caspase-3 and PARP level.  
Its activates SH2 domain-containing phosphatase 1 (SHP-1) activity, leading to p-STAT3 and downstream cyclin B1 and Cdc2 downregulation. Its augments SHP-1 activity by direct binding to N-SH2 and relief of its autoinhibition.

Cell Cycle Analysis

Cell Line: HuCCT-1, KKU-100, and CGCCA cells
Concentration: 0 μM, 1 μM, 2.5 μM, 5 μM, 10 μM
Incubation Time: 24 hours
Result: Showed increased sub-G1 cells and G2-M arrest.

Western Blot Analysis

Cell Line: HuCCT-1, KKU-100, and CGCCA cells
Concentration: 0 μM, 1 μM, 2.5 μM, 5 μM, 10 μM
Incubation Time: 24 hours
Result: Demonstrated significant increase in cleaved caspase-3 and PARP level.

in vivo

SC-43 (10-30 mg/kg; oral gavage; daily; for 23 days; male NCr athymic nude mice) treatment exhibits xenograft tumor growth inhibition, p-STAT3 reduction and SHP-1 activity elevation.

Animal Model: Male NCr athymic nude mice (5-7 weeks of age) injected with HuCCT-1 cells
Dosage: 10 mg/kg or 30 mg/kg
Administration: Oral gavage; daily; for 23 days
Result: Exhibited xenograft tumor growth inhibition, p-STAT3 reduction and SHP-1 activity elevation.

target

TargetValue
SHP-1
()
STAT3
()

SC-43 Preparation Products And Raw materials

Raw materials

Preparation Products

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SC-43 Suppliers

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1400989-25-4, SC-43Related Search:

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  • 1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3-(4-cyanophenoxy)phenyl)urea
  • SC-43
  • Urea, N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-[3-(4-cyanophenoxy)phenyl]-
  • antiproliferative,Inhibitor,SC-43,SHP-1,PTPN6,Phosphatase,Apoptosis,caspase-3,SC 43,anti-fibrotic,p-STAT3,anticancer,orally,SC43,PARP,STAT,inhibit
  • 1400989-25-4