4-[5-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE

Product Name: 4-[5-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE
CAS No.: 170569-86-5
Chemical Name: 4-[5-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE
Synonyms: SC-236;SC-58236;SC 236 - SC 58236;4-[5-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)PYRAZOL-1-YL]BENZENESULFONAMIDE;4-[5-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE;Benzenesulfonamide, 4-[5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-;SC-236,gastric,PPAR,cancer,ischemia,Liver,inhibit,allodynia,Inhibitor,fibrogenesis,neuroprotection,COX,Cyclooxygenase,Apoptosis,TNF-α,Peroxisome proliferator-activated receptors,fibrosis,SC236
CBNumber: CB3243082
Molecular Formula: C16H11ClF3N3O2S
Formula Weight: 401.79
MOL File: Mol file

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4-[5-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE Property

Melting point:: 146-148°C
Boiling point:: 543.4±60.0 °C(Predicted)
Density: 1.54±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: >20mg/mL
form: powder
pka: 9.66±0.10(Predicted)
color: white to off-white

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PZ0106
Product name: SC-236
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $130
Updated: 2024/03/01

Sigma-Aldrich

Product number: PZ0106
Product name: SC-236
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $505
Updated: 2024/03/01

Cayman Chemical

Product number: 10004219
Product name: SC-236
Purity: ≥98%
Packaging: 1mg
Price: $25
Updated: 2024/03/01

Cayman Chemical

Product number: 10004219
Product name: SC-236
Purity: ≥98%
Packaging: 5mg
Price: $69
Updated: 2024/03/01

Cayman Chemical

Product number: 10004219
Product name: SC-236
Purity: ≥98%
Packaging: 10mg
Price: $113
Updated: 2024/03/01

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4-[5-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE Chemical Properties,Usage,Production

Chemical Properties

4-[5-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE is White Solid

Uses

4-[5-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE is a highly selective and potent cyclooxygenase-2 inhibitor which has been shown to induce apoptosis in gastric cells via down-regulation of Akt and then release of cytochrome c. Its anti-inflammatory ef fects allows for potential use in therapy for inflammatory allergic diseases.

Uses

SC-236 has been used as a COX-2 inhibitor to study its effects on the mechano-reflex in rats.

Biological Activity

Selective COX-2 inhibitor (IC 50 values are 0.005 and 17.8 μ M for COX-2 and COX-1 respectively). Displays anti-inflammatory properties and potent antimetastatic activity against both experimental metastases and spontaneous metastases arising following primary tumor excision.

Biochem/physiol Actions

SC-236 exhibits anti-tumor activity in gastric cancer cells by modulating activator protein-1 (AP-1) expression and by blocking the anchorage-independent cell growth. It also exhibits a protective effect against cartilage damage by minimizing the inflammation and pain in osteoarthritis. It is also reported to treat allergic inflammation.

storage

Store at RT

4-[5-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-[5-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE Suppliers

Canada 1 China 53 Germany 1 India 1 Switzerland 1 United Kingdom 2 United States 10 Global 69

J & K SCIENTIFIC LTD.

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Sigma-Aldrich

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Shanghaizehan biopharma technology co., Ltd.

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Tianjin Kailiqi Biotechnology Co., Ltd.

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170569-86-5, 4-[5-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDERelated Search:

NS-398 Indometacin Piroxicam Ibuprofen Phenidone (R)-(-)-IBUPROFEN Meloxicam α,α-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile DEGUELIN 6-METHOXY-2-NAPHTHYLACETIC ACID DUP-697 (S)-(+)-Ketoprofen Naproxen MECLOFENAMATE SODIUM SC-560 Sulindac sulfide SC-1 4-ThiazolecarboxaMide, N-(6-benzoyl-1H-benziMidazol-2-yl)-2-(1-thieno[3,2-d]pyriMidin-4-yl-4-piperidinyl)-

SC-236

4-[5-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE

4-[5-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)PYRAZOL-1-YL]BENZENESULFONAMIDE

SC-58236

SC 236 - SC 58236

Benzenesulfonamide, 4-[5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-

SC-236,gastric,PPAR,cancer,ischemia,Liver,inhibit,allodynia,Inhibitor,fibrogenesis,neuroprotection,COX,Cyclooxygenase,Apoptosis,TNF-α,Peroxisome proliferator-activated receptors,fibrosis,SC236

170569-86-5

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