ChemicalBook > CAS DataBase List > 4-[5-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE

4-[5-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE

Product Name
4-[5-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE
CAS No.
170569-86-5
Chemical Name
4-[5-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE
Synonyms
SC-236;SC-58236;SC 236 - SC 58236;4-[5-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)PYRAZOL-1-YL]BENZENESULFONAMIDE;4-[5-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE;Benzenesulfonamide, 4-[5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-;SC-236,gastric,PPAR,cancer,ischemia,Liver,inhibit,allodynia,Inhibitor,fibrogenesis,neuroprotection,COX,Cyclooxygenase,Apoptosis,TNF-α,Peroxisome proliferator-activated receptors,fibrosis,SC236
CBNumber
CB3243082
Molecular Formula
C16H11ClF3N3O2S
Formula Weight
401.79
MOL File
Mol file
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4-[5-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE Property

Melting point:
146-148°C
Boiling point:
543.4±60.0 °C(Predicted)
Density 
1.54±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: >20mg/mL
form 
powder
pka
9.66±0.10(Predicted)
color 
white to off-white
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PZ0106
Product name
SC-236
Purity
≥98% (HPLC)
Packaging
5mg
Price
$130
Updated
2024/03/01
Sigma-Aldrich
Product number
PZ0106
Product name
SC-236
Purity
≥98% (HPLC)
Packaging
25mg
Price
$505
Updated
2024/03/01
Cayman Chemical
Product number
10004219
Product name
SC-236
Purity
≥98%
Packaging
1mg
Price
$25
Updated
2024/03/01
Cayman Chemical
Product number
10004219
Product name
SC-236
Purity
≥98%
Packaging
5mg
Price
$69
Updated
2024/03/01
Cayman Chemical
Product number
10004219
Product name
SC-236
Purity
≥98%
Packaging
10mg
Price
$113
Updated
2024/03/01
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4-[5-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE Chemical Properties,Usage,Production

Chemical Properties

4-[5-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE is White Solid

Uses

4-[5-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE is a highly selective and potent cyclooxygenase-2 inhibitor which has been shown to induce apoptosis in gastric cells via down-regulation of Akt and then release of cytochrome c. Its anti-inflammatory ef fects allows for potential use in therapy for inflammatory allergic diseases.

Uses

SC-236 has been used as a COX-2 inhibitor to study its effects on the mechano-reflex in rats.

Biological Activity

Selective COX-2 inhibitor (IC 50 values are 0.005 and 17.8 μ M for COX-2 and COX-1 respectively). Displays anti-inflammatory properties and potent antimetastatic activity against both experimental metastases and spontaneous metastases arising following primary tumor excision.

Biochem/physiol Actions

SC-236 exhibits anti-tumor activity in gastric cancer cells by modulating activator protein-1 (AP-1) expression and by blocking the anchorage-independent cell growth. It also exhibits a protective effect against cartilage damage by minimizing the inflammation and pain in osteoarthritis. It is also reported to treat allergic inflammation.

storage

Store at RT

4-[5-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-[5-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE Suppliers

Canada 1 China 56 Germany 1 India 1 Switzerland 1 United Kingdom 2 United States 11 Global 73
Toronto Research Chemicals
Tel
--
Fax
--
Email
info@trc-canada.com
Country
Canada
ProdList
6038
Advantage
71

170569-86-5, 4-[5-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDERelated Search:

NS-398 Indometacin Piroxicam Ibuprofen Phenidone (R)-(-)-IBUPROFEN Meloxicam α,α-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile DEGUELIN 6-METHOXY-2-NAPHTHYLACETIC ACID DUP-697 (S)-(+)-Ketoprofen Naproxen MECLOFENAMATE SODIUM SC-560 Sulindac sulfide SC-1 4-ThiazolecarboxaMide, N-(6-benzoyl-1H-benziMidazol-2-yl)-2-(1-thieno[3,2-d]pyriMidin-4-yl-4-piperidinyl)-

  • SC-236
  • 4-[5-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE
  • 4-[5-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)PYRAZOL-1-YL]BENZENESULFONAMIDE
  • SC-58236
  • SC 236 - SC 58236
  • Benzenesulfonamide, 4-[5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-
  • SC-236,gastric,PPAR,cancer,ischemia,Liver,inhibit,allodynia,Inhibitor,fibrogenesis,neuroprotection,COX,Cyclooxygenase,Apoptosis,TNF-α,Peroxisome proliferator-activated receptors,fibrosis,SC236
  • 170569-86-5
  • Amines
  • Apoptosis
  • Heterocycles
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pfizer compounds
  • Pharmaceuticals