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(R)-(-)-IBUPROFEN

Product Name
(R)-(-)-IBUPROFEN
CAS No.
51146-57-7
Chemical Name
(R)-(-)-IBUPROFEN
Synonyms
(R)-IBUPROFEN;(R)-2-(4-Isobutylphenyl)propanoic acid;l-Ibuprofen;levibuprofen;(-)-Ibuprofen;(-)-Ibuprophen;2-Yl)carbamate;(R)-(-)-Ibupr en;(R)-(-)-IBUPROFEN;Ibuprofen (R)-Isomer
CBNumber
CB3393273
Molecular Formula
C13H18O2
Formula Weight
206.29
MOL File
51146-57-7.mol
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(R)-(-)-IBUPROFEN Property

Melting point:
41-42°C
Boiling point:
305.14°C (rough estimate)
Density 
1.0176 (rough estimate)
refractive index 
1.5290 (estimate)
storage temp. 
Sealed in dry,2-8°C
solubility 
Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
form 
White crystalline powder.
pka
4.41±0.10(Predicted)
color 
Colourless to Pale Beige Oil
Water Solubility 
369.3mg/L(25 ºC)
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Safety

Safety Statements 
24/25
HS Code 
29155090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
16794
Product name
(R)-Ibuprofen
Purity
≥98%
Packaging
100mg
Price
$77
Updated
2024/03/01
Cayman Chemical
Product number
16794
Product name
(R)-Ibuprofen
Purity
≥98%
Packaging
250mg
Price
$177
Updated
2024/03/01
Cayman Chemical
Product number
16794
Product name
(R)-Ibuprofen
Purity
≥98%
Packaging
500mg
Price
$333
Updated
2024/03/01
TRC
Product number
I140005
Product name
(R)-(-)-Ibuprofen
Packaging
100mg
Price
$75
Updated
2021/12/16
ChemScene
Product number
CS-1394
Product name
(R)-(-)-Ibuprofen
Purity
99.86%
Packaging
200mg
Price
$108
Updated
2021/12/16
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(R)-(-)-IBUPROFEN Chemical Properties,Usage,Production

Description

Ibuprofen is a non-steroidal anti-inflammatory drug with diverse biochemical actions, most notably inhibiting COX-1 and COX-2 (IC50s = 2.6 and 1.53 μM, respectively). It is commonly synthesized as a racemic mixture of (S) and (R) isomers (Item No. item 70280). (R)-Ibuprofen is an enantiomer that is generally not considered a COX inhibitor and is instead thought to be involved in pathways of lipid metabolism as it is incorporated into triglycerides along with fatty acids. The (R) enantiomer can, however, inhibit NF-κB activation (IC50 = 121.8 μM) in response to T-cell stimulation as well as block superoxide formation, β-glucuronidase release, and LTB4 generation by stimulated neutrophils (IC50 values range from 40-100 μM). 50-60% of (R)-ibuprofen is inverted to (S)-ibuprofen in humans after oral administration.

Chemical Properties

White Crystalline Solid

Uses

A nonsteroidal anti-inflammatory drug (NSAID); activity resides primarily in the (S)-isomer.

Definition

ChEBI: Levibuprofen is an ibuprofen. It is an enantiomer of a dexibuprofen.

Purification Methods

Crystallise the (+) and (-) acids from EtOH or aqueous EtOH. The racemate which crystallises from pet ether with m 75-77o is sparingly soluble in H2O and has IR (film) 1705 (C=O), 2300—3700 (OH broad)cm-1. It is used as a non-steroidal anti-inflammatory. [Shiori et al. J Org Chem 43 2936 1978, Kaiser et al. J Pharm Sci 65 269 1976, J Pharm Sci 81 221 1992, Freer Acta Cryst (C) 49 1378 1993 for the (S+)-enantiomer.]

(R)-(-)-IBUPROFEN Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-(-)-IBUPROFEN Suppliers

Canada 3 China 112 France 1 Germany 1 India 8 United Kingdom 3 United States 25 Global 153
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44688
Advantage
61
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9513
Advantage
66
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
19179
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@163.com
Country
China
ProdList
283
Advantage
58
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Daicel Chiral Technologies (China)CO.,LTD
Tel
021-50460086-9 15921403865
Fax
+86-21-50462321
Email
han_yajun@dctc.daicel.com
Country
China
ProdList
7195
Advantage
65
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View Lastest Price from (R)-(-)-IBUPROFEN manufacturers

Dideu Industries Group Limited
Product
(R)-(-)-IBUPROFEN 51146-57-7
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-06-15
Career Henan Chemical Co
Product
(R)-(-)-IBUPROFEN 51146-57-7
Price
US $1.00/KG
Min. Order
1KG
Purity
95-99%
Supply Ability
500kg/month
Release date
2019-08-01

51146-57-7, (R)-(-)-IBUPROFENRelated Search:

IBUPROFEN IMPURITY D,IBUPROFEN IMP D IBUPROFEN IMPURITY J α-Methyl-4-(isobutyl)phenylacetic acid, Ibuprofen,Ibuprofen (FDA),R,S-Ibuprofen,rac Ibuprofen,IBUPROFEN,(+/-)-IBUPROFEN IBUPROFEN IMPURITY E,IBUPROFEN IMP E 1-Hydroxyibuprofen (S)-(+)-Ibuprofen 2-[4-(2-Methylpropyl)phenyl] ethanol 6-isobutyl-3-methyl-2,3-dihydro-1H-inden-1-one 4-(2-Methylpropyl)benzeneethanol Ibuprofen EP Impurity I 3-(4-ISOBUTYL-PHENYL)-PROPIONIC ACID p-Isobutylstyrene rac a-Hydroxy Ibuprofen (2RS)-2-(4-N-PROPYLPHENYL)PROPANOIC ACID trans-Ibuprofen IMpurity G IBUPROFEN IMPURITY C,IBUPROFEN IMP C IBUPROFEN IMP N IBUPROFEN IMP F2,Ibuprofen methyl

  • (R)-(-)-2-(4-ISOBUTYLPHENYL)-PROPIONIC ACID
  • (R)-(-)-IBUPROFEN
  • (R)-IBUPROFEN
  • (-)-Ibuprophen
  • (R)-2-(4-Isobutylphenyl)propanoic acid
  • Benzeneacetic acid, α-methyl-4-(2-methylpropyl)-, (R)-
  • Benzeneacetic acid, α-methyl-4-(2-methylpropyl)-, (αR)-
  • l-Ibuprofen
  • R-(-)-p-Isobutylhydratropic acid
  • Ibuprofen Impurity 20((R)-Isomer)
  • (aR)-a-Methyl-4-(2-methylpropyl)benzeneacetic Acid
  • Benzeneacetic acid, a-Methyl-4-(2-Methylpropyl)-, (aR)-
  • (alphaR)-alpha-Methyl-4-(2-methylpropyl)benzeneacetic acid
  • levibuprofen
  • (R)-(-)-Ibupr en
  • (R)-(-)-Ibuprofen ((R)-Ibuprofen)
  • (R)-(-)-ibuprofen reference substance
  • Ibuprofen (R)-Isomer
  • (R)-(-)-IBUPROFEN USP/EP/BP
  • (R)-IbuprofenQ: What is (R)-Ibuprofen Q: What is the CAS Number of (R)-Ibuprofen Q: What is the storage condition of (R)-Ibuprofen Q: What are the applications of (R)-Ibuprofen
  • 5-Triiodo-L-thyronine sodium
  • (-)-Ibuprofen
  • 2-Yl)carbamate
  • (αR)?-α-?Methyl-?4-?(2-?methylpropyl)?-benzeneacetic Acid
  • 51146-57-7
  • 1146-57-7
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Chiral Reagents