DUP-697

Product Name: DUP-697
CAS No.: 88149-94-4
Chemical Name: DUP-697
Synonyms: BFMeT;DUP-697;DuP697,DuP 697;DuP-697 Assay Reagent;5-BROMO-2-(4-FLUOROPHENYL)-3-(4-(METHYLSULFONYL)PHENYL)THIOPHENE;Thiophene, 5-bromo-2-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]-
CBNumber: CB8397180
Molecular Formula: C17H12BrFO2S2
Formula Weight: 411.31
MOL File: 88149-94-4.mol

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DUP-697 Property

storage temp.: 2-8°C
solubility: DMF: 54 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml; DMSO: 15 mg/ml; Ethanol: 7 mg/ml
form: White to off-white solid.

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 70645
Product name: DuP-697
Purity: ≥98%
Packaging: 5mg
Price: $110
Updated: 2024/03/01

Cayman Chemical

Product number: 70645
Product name: DuP-697
Purity: ≥98%
Packaging: 10mg
Price: $175
Updated: 2024/03/01

Cayman Chemical

Product number: 70645
Product name: DuP-697
Purity: ≥98%
Packaging: 25mg
Price: $407
Updated: 2024/03/01

Cayman Chemical

Product number: 70645
Product name: DuP-697
Purity: ≥98%
Packaging: 50mg
Price: $757
Updated: 2024/03/01

Tocris

Product number: 1430
Product name: DuP697
Purity: ≥99%(HPLC)
Packaging: 50
Price: $738
Updated: 2021/12/16

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DUP-697 Chemical Properties,Usage,Production

Description

DuP-697 is a member of the diaryl heterocycle group of selective COX-2 inhibitors which includes MK-966 (rofecoxib), SC-58125, and celecoxib. DuP-697 is a potent and time-dependent inhibitor of COX-2. When tested on isolated recombinant enzymes, DuP-697 is at least 50 times more potent in the inhibition of COX-2 than COX-1. The IC₅₀ values for human recombinant COX-2 are 80 and 40 nM at 5 and 10 minutes, respectively. The IC₅₀ for the inhibition of human recombinant COX-1 after the same time intervals is 9 μM. DuP-697 also attenuates the COX-1 inhibitory activity of non-selective COX inhibitors such as indomethacin.

Uses

DuP-697 is a thiophene that inhibits COX-2 and acts as a NSAID.

Definition

ChEBI: DuP 697 is a member of thiophenes.

Biological Activity

Potent and selective inhibitor of cyclooxygenase-2 (IC 50 values are 10 and 800 nM for COX-2 and COX-1 respectively). Inhibits prostaglandin synthesis and is anti-inflammatory in vivo . Orally active.

storage

Store at +4°C

DUP-697 Preparation Products And Raw materials

Raw materials

Preparation Products

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DUP-697 Suppliers

China 56 Germany 2 Switzerland 1 United Kingdom 2 United States 11 Global 72

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15848
Advantage: 69

Shanghai Hekang Biotechnology Co., Ltd.

Tel: 18939837085
Fax: 2880152141(QQ)
Email: youchemicals@gmail.com
Country: China
ProdList: 1824
Advantage: 55

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8449
Advantage: 60

Henan CoreyChem Co., Ltd

Tel: 0371-86658258
Fax: 0371-60996044
Email: info@coreychem.com
Country: China
ProdList: 10457
Advantage: 58

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9708
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12308
Advantage: 58

Hangzhou Synstar pharmaceutical Technology CO.,Ltd

Tel: 0571-85361029
Fax: 0571-85361029
Email: synstar518@163.com
Country: China
ProdList: 1991
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 19892
Advantage: 58

Zhejiang J&C Biological Technology Co.,Limited

Tel: +1-2135480471 +1-2135480471
Email: sales@sarms4muscle.com
Country: China
ProdList: 10523
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11289
Advantage: 58

88149-94-4, DUP-697Related Search:

NS-398 Indometacin Piroxicam (S)-(+)-Ibuprofen Ibuprofen Phenidone (R)-(-)-IBUPROFEN 4-[5-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE Meloxicam Naproxen MECLOFENAMATE SODIUM SC-560 Sulindac sulfide APHS N-(2-PHENYLETHYL)-INDOMETHACIN AMIDE 2-(4-Fluorophenyl)-thiophene DUP-697 2-BROMO-5-PHENYLTHIOPHENE

DUP-697

5-BROMO-2-(4-FLUOROPHENYL)-3-(4-(METHYLSULFONYL)PHENYL)THIOPHENE

BFMeT

DuP-697 Assay Reagent

Thiophene, 5-bromo-2-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]-

DuP697,DuP 697

88149-94-4

C17H12BrFO2S2

Lipid signaling

API intermediates