ChemicalBook > CAS DataBase List > DUP-697

DUP-697

Product Name
DUP-697
CAS No.
88149-94-4
Chemical Name
DUP-697
Synonyms
BFMeT;DUP-697;DuP697,DuP 697;DuP-697 Assay Reagent;5-BROMO-2-(4-FLUOROPHENYL)-3-(4-(METHYLSULFONYL)PHENYL)THIOPHENE;Thiophene, 5-bromo-2-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]-
CBNumber
CB8397180
Molecular Formula
C17H12BrFO2S2
Formula Weight
411.31
MOL File
88149-94-4.mol
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DUP-697 Property

storage temp. 
2-8°C
solubility 
DMF: 54 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml; DMSO: 15 mg/ml; Ethanol: 7 mg/ml
form 
White to off-white solid.
color 
White to off-white
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
70645
Product name
DuP-697
Purity
≥98%
Packaging
5mg
Price
$110
Updated
2024/03/01
Cayman Chemical
Product number
70645
Product name
DuP-697
Purity
≥98%
Packaging
10mg
Price
$175
Updated
2024/03/01
Cayman Chemical
Product number
70645
Product name
DuP-697
Purity
≥98%
Packaging
25mg
Price
$407
Updated
2024/03/01
Cayman Chemical
Product number
70645
Product name
DuP-697
Purity
≥98%
Packaging
50mg
Price
$757
Updated
2024/03/01
Tocris
Product number
1430
Product name
DuP697
Purity
≥99%(HPLC)
Packaging
50
Price
$738
Updated
2021/12/16
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DUP-697 Chemical Properties,Usage,Production

Description

DuP-697 is a member of the diaryl heterocycle group of selective COX-2 inhibitors which includes MK-966 (rofecoxib), SC-58125, and celecoxib. DuP-697 is a potent and time-dependent inhibitor of COX-2. When tested on isolated recombinant enzymes, DuP-697 is at least 50 times more potent in the inhibition of COX-2 than COX-1. The IC50 values for human recombinant COX-2 are 80 and 40 nM at 5 and 10 minutes, respectively. The IC50 for the inhibition of human recombinant COX-1 after the same time intervals is 9 μM. DuP-697 also attenuates the COX-1 inhibitory activity of non-selective COX inhibitors such as indomethacin.

Uses

DuP-697 is a thiophene that inhibits COX-2 and acts as a NSAID.

Definition

ChEBI: DuP 697 is a member of thiophenes.

Biological Activity

Potent and selective inhibitor of cyclooxygenase-2 (IC 50 values are 10 and 800 nM for COX-2 and COX-1 respectively). Inhibits prostaglandin synthesis and is anti-inflammatory in vivo . Orally active.

storage

Store at +4°C

DUP-697 Preparation Products And Raw materials

Raw materials

Preparation Products

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DUP-697 Suppliers

China 58 Germany 2 Switzerland 1 United Kingdom 2 United States 11 Global 74
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88149-94-4, DUP-697Related Search:

NS-398 Indometacin Piroxicam (S)-(+)-Ibuprofen Ibuprofen Phenidone (R)-(-)-IBUPROFEN 4-[5-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE Meloxicam Naproxen MECLOFENAMATE SODIUM SC-560 Sulindac sulfide APHS N-(2-PHENYLETHYL)-INDOMETHACIN AMIDE 2-(4-Fluorophenyl)-thiophene DUP-697 2-BROMO-5-PHENYLTHIOPHENE

  • DUP-697
  • 5-BROMO-2-(4-FLUOROPHENYL)-3-(4-(METHYLSULFONYL)PHENYL)THIOPHENE
  • BFMeT
  • DuP-697 Assay Reagent
  • Thiophene, 5-bromo-2-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]-
  • DuP697,DuP 697
  • 88149-94-4
  • C17H12BrFO2S2
  • Lipid signaling
  • API intermediates