COH000

Product Name: COH000
CAS No.: 1534358-79-6
Chemical Name: COH000
Synonyms: COH000;CID 46835111;SID 99212997);COH000 (COH-000;COH000, 10 mM in DMSO;COH000;COH-000;COH 000;dimethyl (1R,4S)-1-[1-anilino-2-(4-methylphenyl)ethyl]-7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylate;(1R,4S)-Dimethyl 1-((R)-1-(phenylamino)-2-(p-tolyl)ethyl)-7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylate;7-Oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylic acid, 1-[(1R)-2-(4-methylphenyl)-1-(phenylamino)ethyl]-, 2,3-dimethyl ester, (1R,4S)-;Ubiquitin conjugating enzyme,E1 activating enzyme,COH 000,COH000,E1/E2/E3 Enzyme,COH-000,E2 conjugating enzyme,Ubiquitin ligase,Ubiquitin activating enzyme,Inhibitor,E3 ligating enzyme,inhibit
CBNumber: CB94844656
Molecular Formula: C25H25NO5
Formula Weight: 419.47
MOL File: 1534358-79-6.mol

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COH000 Property

Boiling point:: 581.1±50.0 °C(Predicted)
Density: 1.289±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
solubility: DMF: 11 mg/mL; DMSO: 13 mg/mL; Ethanol: Slightly Soluble; PBS (pH 7.2): 0.04 mg/mL
form: A solid
pka: 4.17±0.50(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0082002
Product name: COH000
Purity: >98.0%
Packaging: 5mg
Price: $650
Updated: 2021/12/16

Axon Medchem

Product number: Axon2935
Product name: COH000
Purity: 98%
Packaging: 25mg
Price: $770
Updated: 2021/12/16

ChemScene

Product number: CS-0082002
Product name: COH000
Purity: >98.0%
Packaging: 10mg
Price: $850
Updated: 2021/12/16

ChemScene

Product number: CS-0082002
Product name: COH000
Purity: >98.0%
Packaging: 50mg
Price: $2400
Updated: 2021/12/16

ChemScene

Product number: CS-0082002
Product name: COH000
Purity: >98.0%
Packaging: 100mg
Price: $3400
Updated: 2021/12/16

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COH000 Chemical Properties,Usage,Production

Uses

COH000 is an allosteric, covalent and irreversible inhibitor of ubiquitin-like 1-activating enzyme (SUMO-activating enzyme) (E1), with an IC50 of 0.2 μM for SUMOylation in vitro[1].

References

[1] Li YJ, et al. Allosteric Inhibition of Ubiquitin-like Modifications by a Class of Inhibitor of SUMO-Activating Enzyme. Cell Chem Biol. 2018 Dec 5. pii: S2451-9456(18)30386-6. DOI:10.1016/j.chembiol.2018.10.026

COH000 Preparation Products And Raw materials

Raw materials

Preparation Products

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COH000 Suppliers

China 40 United States 6 Global 46

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7778
Advantage: 56

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4757
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 8011
Advantage: 55

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 18101056239
Email: 3193328036@qq.com
Country: China
ProdList: 29760
Advantage: 68

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
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InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
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HANGZHOU CLAP TECHNOLOGY CO.,LTD

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Email: sales@hzclap.com
Country: CHINA
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1534358-79-6, COH000Related Search:

Octadecyl methacrylate N-Methylaniline Dimethyl sulfoxide Phenylsilane

COH000

CID 46835111

COH000 (COH-000

SID 99212997)

COH000;COH-000;COH 000

(1R,4S)-Dimethyl 1-((R)-1-(phenylamino)-2-(p-tolyl)ethyl)-7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylate

Ubiquitin conjugating enzyme,E1 activating enzyme,COH 000,COH000,E1/E2/E3 Enzyme,COH-000,E2 conjugating enzyme,Ubiquitin ligase,Ubiquitin activating enzyme,Inhibitor,E3 ligating enzyme,inhibit

7-Oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylic acid, 1-[(1R)-2-(4-methylphenyl)-1-(phenylamino)ethyl]-, 2,3-dimethyl ester, (1R,4S)-

dimethyl (1R,4S)-1-[1-anilino-2-(4-methylphenyl)ethyl]-7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylate

COH000, 10 mM in DMSO

1534358-79-6