Propargyl-PEG4-CH2CO2-NHS
- Product Name
- Propargyl-PEG4-CH2CO2-NHS
- CAS No.
- 2144777-76-2
- Chemical Name
- Propargyl-PEG4-CH2CO2-NHS
- Synonyms
- Propargyl-PEG3-CH2COONHS;Propargyl-PEG4-CH2CO2-NHS;Propargyl-PEG3-CH2CONHS ester;Propargyl-PEG3-O-CH2-NHS ester;Propargyl-PEG4-CH2COO-NHS ester;Propargyl-PEG4-CH2COOH NHS Ester;2,5-dioxopyrrolidin-1-yl 3,6,9,12-tetraoxapentadec-14-ynoate;3,6,9,12-Tetraoxapentadec-14-ynoic acid, 2,5-dioxo-1-pyrrolidinyl ester
- CBNumber
- CB94849646
- Molecular Formula
- C15H21NO8
- Formula Weight
- 343.33
- MOL File
- 2144777-76-2.mol
Propargyl-PEG4-CH2CO2-NHS Property
- solubility
- Soluble in DMSO, DCM, DMF
N-Bromosuccinimide Price
- Product number
- BP-23811
- Product name
- Propargyl-PEG4-CH2CO2-NHS
- Packaging
- 500mg
- Price
- $650
- Updated
- 2021/12/16
Propargyl-PEG4-CH2CO2-NHS Chemical Properties,Usage,Production
Description
Propargyl-PEG4-CH2CO2-NHS has a propargyl group and an NHS group. This reagent is amine reactive, thus, useful for derivatizing biomolecules with amine group. The propargyl group reacts with azides via copper catalyzed azide-alkyne Click Chemistry to form stable triazole bond.
Uses
Propargyl-PEG4-CH2CO2-NHS (compound P-7) is a PEG derivative containing a propargyl group and an NHS group. Propargyl-PEG4-CH2CO2-NHS is an ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG4-CH2CO2-NHS is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups[1].
References
[1] Woo Sung-ho, et al. Composé comprenant un groupe auto-immolable et conjugué ligand-médicament le comprenant. WO2024005460A1.
Propargyl-PEG4-CH2CO2-NHS Preparation Products And Raw materials
Raw materials
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