DMX-5084

Product Name: DMX-5084
CAS No.: 2306178-56-1
Chemical Name: DMX-5084
Synonyms: DMX-5084;DMX-5084 ，S0268;DMX-5804, 10 mM in DMSO;5-(4-(2-Methoxyethoxy)phenyl)-7-phenyl-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one;inhibit,DMX-5804,Inhibitor,DMX5804,MAP4K,DMX 5804,MAPK Kinase Kinase Kinase;4H-Pyrrolo[2,3-d]pyrimidin-4-one, 3,7-dihydro-5-[4-(2-methoxyethoxy)phenyl]-7-phenyl-
CBNumber: CB94866454
Molecular Formula: C21H19N3O3
Formula Weight: 361.39
MOL File: 2306178-56-1.mol

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DMX-5084 Property

storage temp.: Store at -20°C
solubility: DMSO : 125 mg/mL (345.89 mM; Need ultrasonic)
form: Solid
color: Off-white to yellow

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0090763
Product name: DMX-5804
Purity: 99.90%
Packaging: 5mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0090763
Product name: DMX-5804
Purity: 99.90%
Packaging: 10mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0090763
Product name: DMX-5804
Purity: 99.90%
Packaging: 50mg
Price: $1650
Updated: 2021/12/16

ChemScene

Product number: CS-0090763
Product name: DMX-5804
Purity: 99.90%
Packaging: 100mg
Price: $2650
Updated: 2021/12/16

DC Chemicals

Product number: DC22307
Product name: DMX-5804
Purity: >98%
Packaging: 250mg
Price: $950
Updated: 2021/12/16

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DMX-5084 Chemical Properties,Usage,Production

Uses

DMX-5804 is a potent, orally active and selective MAP4K4 inhibitor, with an IC50 of 3 nM, a pIC50 of 8.55 for human MAP4K4, less potent on MINK1/MAP4K6 (pIC50, 8.18), and TNIK/MAP4K7 (pIC50, 7.96). DMX-5804 enhances cardiomyocyte survival, and reduces ischemia-reperfusion injury in mice[1].

IC 50

MAP4K4: 3 nM (IC₅₀); MAP4K4: 8.55 (pIC₅₀); MINK1/MAP4K6: 8.18 (pIC₅₀); TNIK/MAP4K7: 7.96 (pIC₅₀); GCK/MAP4K2: 6.50 (pIC₅₀); KHS/MAP4K5: 6.36 (pIC₅₀); GLK/MAP4K3: 4.95 (pIC₅₀); MLK1/MAP3K9: 7.19 (pIC₅₀); MLK3/MAP3K11: 6.99 (pIC₅₀); NUAK: 6.88 (pIC₅₀); VEGFR: 5.72 (pIC₅₀); ABL1: 5.80 (pIC₅₀); Aurora B: 5.49 (pIC₅₀); FLT3: 5.31 (pIC₅₀); GSK3β: 4.66 (pIC₅₀)

References

[1] Fiedler LR, et al. MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo. Cell Stem Cell. 2019 Mar 1. pii: S1934-5909(19)30013-X. DOI:10.1016/j.stem.2019.01.013

DMX-5084 Preparation Products And Raw materials

Raw materials

Preparation Products

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DMX-5084 Suppliers

China 40 United States 4 Global 44

Shanghai JiYi Biotechnology Co. Ltd.

Tel: 13621943973
Fax: -
Email: sales@shjiyipharmatech.com
Country: China
ProdList: 1166
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Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4769
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9125
Advantage: 58

Heze Development Zone chuangli Chemical Co., Ltd.

Tel: 0530-+86-530-529 6766，+86-15666160102 15666160102
Fax: 0530-529 6766
Email: info@chuangli-chem.com
Country: China
ProdList: 836
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Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
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InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

Jingmo (Xiamen) Biotechnology Co., Ltd

Tel: 13621943973; 13621943973
Email: sales@jamxmpharmatech.com
Country: China
ProdList: 1168
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2306178-56-1, DMX-5084Related Search:

Dimethyl sulfide

DMX-5084

4H-Pyrrolo[2,3-d]pyrimidin-4-one, 3,7-dihydro-5-[4-(2-methoxyethoxy)phenyl]-7-phenyl-

inhibit,DMX-5804,Inhibitor,DMX5804,MAP4K,DMX 5804,MAPK Kinase Kinase Kinase

5-(4-(2-Methoxyethoxy)phenyl)-7-phenyl-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one

DMX-5804, 10 mM in DMSO

DMX-5084 ，S0268

2306178-56-1