ChemicalBook > CAS DataBase List > 8-M-PDOT

8-M-PDOT

Product Name
8-M-PDOT
CAS No.
134865-70-6
Chemical Name
8-M-PDOT
Synonyms
AH 002;8-M-PDOT;8 M PDOT,8MPDOT;8-METHOXY-2-PROPIONAMIDOTETRALIN;Propanamide, N-(1,2,3,4-tetrahydro-8-methoxy-2-naphthalenyl)-
CBNumber
CB9487996
Molecular Formula
C14H19NO2
Formula Weight
233.31
MOL File
134865-70-6.mol
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8-M-PDOT Property

Boiling point:
447.8±45.0 °C(Predicted)
Density 
1.09±0.1 g/cm3(Predicted)
storage temp. 
Store at RT
solubility 
Soluble to 50 mM in ethanol and to 100 mM in DMSO
form 
Powder
pka
15.87±0.20(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
29521
Product name
8-M-PDOT
Packaging
5mg
Price
$82
Updated
2024/03/01
Cayman Chemical
Product number
29521
Product name
8-M-PDOT
Packaging
10mg
Price
$138
Updated
2024/03/01
Cayman Chemical
Product number
29521
Product name
8-M-PDOT
Packaging
25mg
Price
$324
Updated
2024/03/01
Cayman Chemical
Product number
29521
Product name
8-M-PDOT
Packaging
50mg
Price
$606
Updated
2024/03/01
Tocris
Product number
1035
Product name
8-M-PDOT
Purity
≥99%(HPLC)
Packaging
50
Price
$504
Updated
2021/12/16
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8-M-PDOT Chemical Properties,Usage,Production

Description

8-M-PDOT is a melatonin receptor 2 (MT2) agonist (Ki = 1.12 nM). It is 5.2-fold selective for MT2 over MT1 receptors in a radioligand binding assay. Striatal microinfusion of 8-M-PDOT (10 μg/μl) increases the percentage of time spent in the open arms of the elevated plus maze, indicating anxiolytic-like activity, in a rat model of rotenone-induced Parkinson''s disease.

Uses

AH 002 is a selective melatonin receptor agonist.

Biological Activity

Melatonin receptor agonist, 20-fold selective for the MT 2 (vs MT 1 ) subtype. At human recombinant MT 1 and MT 2 receptors, displays pK i values of 8.23 and 8.95 respectively.

8-M-PDOT Preparation Products And Raw materials

Raw materials

Preparation Products

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8-M-PDOT Suppliers

China 19 Germany 1 United Kingdom 2 United States 7 Global 29
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15848
Advantage
69
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8449
Advantage
60
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9709
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
19892
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11289
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
29778
Advantage
58
Shanghai Universal Biotech Co.,Ltd
Tel
18768175414
Email
gaojun@univ-bio.com
Country
China
ProdList
24998
Advantage
58
Kaifeng Mingren Pharmaceutical Co.,LTD
Tel
0371-65741762
Fax
QQ：2860768577
Email
sales@hasunny.com
Country
China
ProdList
2380
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24131
Advantage
58
Nantong QuanYi Biotechnology Co., Ltd
Tel
0513-66337626 18051384581
Email
sales@chemhifuture.com
Country
China
ProdList
4030
Advantage
58

134865-70-6, 8-M-PDOTRelated Search:

1-(2-METHOXY-PHENYL)-2-BUTANAMINE 2-Amtt 8-METHOXY-2-AMINOTETRALIN 8-M-PDOT Methoxyphenamine

  • 8-METHOXY-2-PROPIONAMIDOTETRALIN
  • 8-M-PDOT
  • AH 002
  • 8 M PDOT,8MPDOT
  • Propanamide, N-(1,2,3,4-tetrahydro-8-methoxy-2-naphthalenyl)-
  • 134865-70-6