8-M-PDOT

Product Name: 8-M-PDOT
CAS No.: 134865-70-6
Chemical Name: 8-M-PDOT
Synonyms: AH 002;8-M-PDOT;8 M PDOT,8MPDOT;8-M-PDOT, 10 mM in DMSO;8-METHOXY-2-PROPIONAMIDOTETRALIN;Propanamide, N-(1,2,3,4-tetrahydro-8-methoxy-2-naphthalenyl)-
CBNumber: CB9487996
Molecular Formula: C14H19NO2
Formula Weight: 233.31
MOL File: 134865-70-6.mol

More

Less

8-M-PDOT Property

Boiling point:: 447.8±45.0 °C(Predicted)
Density: 1.09±0.1 g/cm3(Predicted)
storage temp.: Store at RT
solubility: Soluble to 50 mM in ethanol and to 100 mM in DMSO
form: Powder
pka: 15.87±0.20(Predicted)
color: White to off-white

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 29521
Product name: 8-M-PDOT
Packaging: 5mg
Price: $82
Updated: 2024/03/01

Cayman Chemical

Product number: 29521
Product name: 8-M-PDOT
Packaging: 10mg
Price: $138
Updated: 2024/03/01

Cayman Chemical

Product number: 29521
Product name: 8-M-PDOT
Packaging: 25mg
Price: $324
Updated: 2024/03/01

Cayman Chemical

Product number: 29521
Product name: 8-M-PDOT
Packaging: 50mg
Price: $606
Updated: 2024/03/01

Tocris

Product number: 1035
Product name: 8-M-PDOT
Purity: ≥99%(HPLC)
Packaging: 50
Price: $504
Updated: 2021/12/16

More

Less

8-M-PDOT Chemical Properties,Usage,Production

Description

8-M-PDOT is a melatonin receptor 2 (MT₂) agonist (K_i = 1.12 nM). It is 5.2-fold selective for MT₂ over MT₁ receptors in a radioligand binding assay. Striatal microinfusion of 8-M-PDOT (10 μg/μl) increases the percentage of time spent in the open arms of the elevated plus maze, indicating anxiolytic-like activity, in a rat model of rotenone-induced Parkinson''s disease.

Uses

AH 002 is a selective melatonin receptor agonist.

Biological Activity

Melatonin receptor agonist, 20-fold selective for the MT 2 (vs MT 1 ) subtype. At human recombinant MT 1 and MT 2 receptors, displays pK i values of 8.23 and 8.95 respectively.

in vivo

8-M-PDOT (10 μg/μL; administrated into the dorsal striatum by bilateral cannulas; for 30 minutes; male Wistar rats) treatment shows anxiolytic-like effect^[2].

Animal Model:	Male Wistar rats (280-320 g) with Rotenone^[2]
Dosage:	10 μg/μL
Administration:	Administrated into the dorsal striatum by bilateral cannulas; for 30 minutes
Result:	Increased percentage of time spent in the open arms and in the number of open arms entries.

IC 50

MT2

References

[1] CHRISTOPHER BROWNING. Pharmacological characterization of human recombinant melatonin mt1 and MT2 receptors[J]. British Journal of Pharmacology, 2009, 129 5: 877-886. DOI: 10.1038/sj.bjp.0703130
[2] ANA CAROLINA D. NOSEDA. REM sleep deprivation promotes a dopaminergic influence in the striatal MT2 anxiolytic-like effects[J]. Sleep Science, 2016, 9 1: Pages 47-54. DOI: 10.1016/j.slsci.2015.10.002

8-M-PDOT Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

8-M-PDOT Suppliers

China 27 Germany 1 United Kingdom 2 United States 10 Global 40

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 12952
Advantage: 65

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
Advantage: 60

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29757
Advantage: 58

Shanghai Universal Biotech Co.,Ltd

Tel: 15921930842 15921930842
Email: yh-wang@univ-bio.com
Country: China
ProdList: 25004
Advantage: 58

Kaifeng Mingren Pharmaceutical Co.,LTD

Tel: 0371-65741762
Fax: QQ：2860768577
Email: sales@hasunny.com
Country: China
ProdList: 2380
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

134865-70-6, 8-M-PDOTRelated Search:

1-(2-METHOXY-PHENYL)-2-BUTANAMINE 2-Amtt 8-METHOXY-2-AMINOTETRALIN 8-M-PDOT Methoxyphenamine

8-METHOXY-2-PROPIONAMIDOTETRALIN

8-M-PDOT

AH 002

8 M PDOT,8MPDOT

Propanamide, N-(1,2,3,4-tetrahydro-8-methoxy-2-naphthalenyl)-

8-M-PDOT, 10 mM in DMSO

134865-70-6