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8-M-PDOT

Product Name
8-M-PDOT
CAS No.
134865-70-6
Chemical Name
8-M-PDOT
Synonyms
AH 002;8-M-PDOT;8 M PDOT,8MPDOT;8-METHOXY-2-PROPIONAMIDOTETRALIN;Propanamide, N-(1,2,3,4-tetrahydro-8-methoxy-2-naphthalenyl)-
CBNumber
CB9487996
Molecular Formula
C14H19NO2
Formula Weight
233.31
MOL File
134865-70-6.mol
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8-M-PDOT Property

Boiling point:
447.8±45.0 °C(Predicted)
Density 
1.09±0.1 g/cm3(Predicted)
storage temp. 
Store at RT
solubility 
Soluble to 50 mM in ethanol and to 100 mM in DMSO
form 
Powder
pka
15.87±0.20(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
29521
Product name
8-M-PDOT
Packaging
5mg
Price
$82
Updated
2024/03/01
Cayman Chemical
Product number
29521
Product name
8-M-PDOT
Packaging
10mg
Price
$138
Updated
2024/03/01
Cayman Chemical
Product number
29521
Product name
8-M-PDOT
Packaging
25mg
Price
$324
Updated
2024/03/01
Cayman Chemical
Product number
29521
Product name
8-M-PDOT
Packaging
50mg
Price
$606
Updated
2024/03/01
Tocris
Product number
1035
Product name
8-M-PDOT
Purity
≥99%(HPLC)
Packaging
10
Price
$120
Updated
2021/12/16
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8-M-PDOT Chemical Properties,Usage,Production

Description

8-M-PDOT is a melatonin receptor 2 (MT2) agonist (Ki = 1.12 nM). It is 5.2-fold selective for MT2 over MT1 receptors in a radioligand binding assay. Striatal microinfusion of 8-M-PDOT (10 μg/μl) increases the percentage of time spent in the open arms of the elevated plus maze, indicating anxiolytic-like activity, in a rat model of rotenone-induced Parkinson''s disease.

Uses

AH 002 is a selective melatonin receptor agonist.

Biological Activity

Melatonin receptor agonist, 20-fold selective for the MT 2 (vs MT 1 ) subtype. At human recombinant MT 1 and MT 2 receptors, displays pK i values of 8.23 and 8.95 respectively.

8-M-PDOT Preparation Products And Raw materials

Raw materials

Preparation Products

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8-M-PDOT Suppliers

China 20 Germany 1 United Kingdom 2 United States 9 Global 32
Service Chemical Inc.
Tel
--
Fax
--
Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71

134865-70-6, 8-M-PDOTRelated Search:

1-(2-METHOXY-PHENYL)-2-BUTANAMINE 2-Amtt 8-METHOXY-2-AMINOTETRALIN 8-M-PDOT Methoxyphenamine

  • 8-METHOXY-2-PROPIONAMIDOTETRALIN
  • 8-M-PDOT
  • AH 002
  • 8 M PDOT,8MPDOT
  • Propanamide, N-(1,2,3,4-tetrahydro-8-methoxy-2-naphthalenyl)-
  • 134865-70-6