(2-BROMOETHOXY)-TERT-BUTYLDIMETHYLSILANE

Product Name: (2-BROMOETHOXY)-TERT-BUTYLDIMETHYLSILANE
CAS No.: 86864-60-0
Chemical Name: (2-BROMOETHOXY)-TERT-BUTYLDIMETHYLSILANE
Synonyms: 2-Bromoethyloxy(tert-butyl)dimethylsilane;DK933;DK417;DKSI039;OZAN-008;DKFELEX0249;2-bromethanolTBDMSether;2-BROMOETHOXY-T-BUTYL DIMETHYLSILANE;2-(t-butyldimethylsiloxy)ethylbromide;(t-butyldiMethylsiloxy)-2-ethylbroMide
CBNumber: CB9489026
Molecular Formula: C8H19BrOSi
Formula Weight: 239.23
MOL File: 86864-60-0.mol

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(2-BROMOETHOXY)-TERT-BUTYLDIMETHYLSILANE Property

Boiling point:: 70-75 °C2.5 mm Hg(lit.)
Density: 1.115 g/mL at 25 °C(lit.)
refractive index: n20/D 1.444(lit.)
Flash point:: 163 °F
storage temp.: 2-8°C
form: Liquid
Specific Gravity: 1.115
color: White to pale yellow
Hydrolytic Sensitivity: 7: reacts slowly with moisture/water
InChI: InChI=1S/C8H19BrOSi/c1-8(2,3)11(4,5)10-7-6-9/h6-7H2,1-5H3
InChIKey: JBKINHFZTVLNEM-UHFFFAOYSA-N
SMILES: [Si](OCCBr)(C(C)(C)C)(C)C

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-37/39
WGK Germany: 3
HS Code: 29319090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 428426
Product name: (2-Bromoethoxy)-tert-butyldimethylsilane
Purity: 99%
Packaging: 1g
Price: $28.97
Updated: 2025/07/31

Sigma-Aldrich

Product number: 428426
Product name: (2-Bromoethoxy)-tert-butyldimethylsilane
Purity: 99%
Packaging: 10g
Price: $141
Updated: 2025/07/31

TCI Chemical

Product number: B4505
Product name: (2-Bromoethoxy)-tert-butyldimethylsilane
Packaging: 5G
Price: $47
Updated: 2025/07/31

TCI Chemical

Product number: B4505
Product name: (2-Bromoethoxy)-tert-butyldimethylsilane
Packaging: 25G
Price: $155
Updated: 2025/07/31

TRC

Product number: B686625
Product name: (2-Bromoethoxy)-tert-butyldimethylsilane
Packaging: 100g
Price: $250
Updated: 2021/12/16

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(2-BROMOETHOXY)-TERT-BUTYLDIMETHYLSILANE Chemical Properties,Usage,Production

Chemical Properties

colorless liquid

Uses

(2-Bromoethoxy)-tert-butyldimethylsilane was used in the synthesis of 4-(3-hydroxypropyl)-4′-methyl-2,2′-bipyridine.
It may be used as a reagent for the selective N-alkylation of 5-piperazin-1-yl-1H-indole and (1H-indol-2-yl)-piperazin-1-yl-methanone and also in the synthesis of 2-[3-[(3,4,5-trimethoxyphenyl)thio]-1H-indol-5-yloxy]ethanol.

Uses

(2-Bromoethoxy)-tert-butyldimethylsilane can be used in N-alkylation with 5-piperazin-1-yl-1H-indole to synthesize 5-(4-(2-((tert-butyldimethylsilyl)oxy)ethyl)piperazin-1-yl)-1H-indole.

Preparation

In a round-bottom flask, TBDMSC1 (10.61 g, 70.42 mmol) and imidazole (6.23 g, 91.55 mmol) were dissolved in DMF (12.5 mL) and the solution was stirred at 30 mmat rt. Then, 2-bromoethanol (5 mL, 70.42 mmol) was added and the mixture was stirred at room temperature for 16 h. The reaction mixture was partitioned between Et20 and water. The organic layer was dried over MgSO4, filtered and concentrated in vacuo to give 17 g of (2-Bromoethoxy)-tert-butyldimethylsilane (quantitative yield, colorless oil).

General Description

(2-Bromoethoxy)-tert-butyldimethylsilane is a silane derivative.

Synthesis

18162-48-6

540-51-2

86864-60-0

To a solution of 2-bromoethanol (3.5 mL, 49.3 mmol) in dichloromethane (DCM, 20 mL) was sequentially added tert-butyldimethylchlorosilane (TBDMSCl, 8.17 g, 54.2 mmol), triethylamine (Et3N, 13.85 mL, 98.6 mmol) and 4-dimethylaminopyridine (DMAP, 55 mg, 0.394 mmol). The reaction mixture was stirred at room temperature for 15 hours. After completion of the reaction, the mixture was concentrated under reduced pressure. The residue was partitioned with 1N hydrochloric acid (HCl) and ethyl acetate (EtOAc). The aqueous phase was extracted with ethyl acetate. The combined organic phases were washed with saturated brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give a yellow oily crude product. Purification by column chromatography (hexane as eluent) afforded the colorless oily product [(2-bromoethoxy)tert-butyldimethylsilane] (11.8 g, 49.3 mmol, 100% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 3.89 (t, 2H), 3.40 (t, 2H), 0.91 (s, 9H), 0.091 (s, 6H); GC/MS (C8H19BrOSi) showed the molecular ion peak m/z 239 (M+).

References

[1] Patent: WO2005/9389, 2005, A2. Location in patent: Page/Page column 134
[2] Patent: WO2017/216293, 2017, A1. Location in patent: Page/Page column 78
[3] Patent: WO2005/9389, 2005, A2. Location in patent: Page/Page column 134
[4] Patent: US2004/116475, 2004, A1. Location in patent: Page/Page column 30
[5] Patent: WO2004/60367, 2004, A1. Location in patent: Page/Page column 81

(2-BROMOETHOXY)-TERT-BUTYLDIMETHYLSILANE Preparation Products And Raw materials

Raw materials

Preparation Products

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(2-BROMOETHOXY)-TERT-BUTYLDIMETHYLSILANE Suppliers

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View Lastest Price from (2-BROMOETHOXY)-TERT-BUTYLDIMETHYLSILANE manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: (2-BROMOETHOXY)-TERT-BUTYLDIMETHYLSILANE 86864-60-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-27

Shaanxi Dideu New Materials Co. Ltd

Product: (2-BROMOETHOXY)-TERT-BUTYLDIMETHYLSILANE 86864-60-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-03-01

Zhuozhou Wenxi import and Export Co., Ltd

Product: (2-Bromoethoxy)-tert-butyldimethylsilane 86864-60-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

86864-60-0, (2-BROMOETHOXY)-TERT-BUTYLDIMETHYLSILANERelated Search:

DIMETHYLSILANE 1,2-Bis(chlorodimethylsilyl)ethane Phenol Hydroxy silicone oil DISILANE Barium hydroxide Acetaldehyde Ethanol Sodium nitrite Dimethyldimethoxysilane Hexamethylcyclotrisiloxane (3-PHENYLPROPYL)METHYLDICHLOROSILANE (2-BROMOPHENYLETHYNYL)TRIMETHYLSILANE (2-METHYLALLYLOXY)TRIMETHYLSILANE, 95% 1-Cyclohexenyloxytrimethylsilane tert-Butyldimethylsilyl chloride TERT-BUTYL 4-AMINO-3-FLUOROPIPERIDINE-1-CARBOXYLATE T-BUTYLDIMETHYLSILANE

2-(tert-Butyldimethylsilyloxy)-1-bromoethane

2-(tert-Butyldimethylsilyloxy)bromoethane

2-(tert-Butyldimethylsilyloxy)ethyl bromide

2-Bromoethyl tert-butyldimethylsilyl ether

2-Bromoethyloxy(tert-butyl)dimethylsilane

(1-(2-BroMoethoxy)-2-Methylpropan-2-yl)diMethylsilane

Silane,(2-broMoethoxy)(1,1-diMethylethyl)diMethyl-

(2-BroMoethoxy)-tert-butyldiMethylsilane 99%

(2-BroMoethoxy)-tert-butyldiMethylsilane, 98%+

(2-Bromoethoxy)-<i>tert-</i>-butyldimethylsilane

(2-Bromoethoxy)-tert-butyldimethylsilane, Stabilized with sodium carbonate

2-BROMOETHOXY-T-BUTYL DIMETHYLSILANE

(2-BROMOETHOXY)-TERT-BUTYLDIMETHYLSILANE

(2-BroMoethoxy)-tert-butyldiMethylsilane , stabilized

OZAN-008

Hebei Fulong Import and Export Co., Ltd

2-(t-butyldimethylsiloxy)ethylbromide

(2-BroMoethoxy)-tert-butyldiMethylsilane, 98+%, stabilized

(t-butyldiMethylsiloxy)-2-ethylbroMide

(tert-Butyl)(2-bromoethoxy)dimethylsilane

[(2-Bromoethyl)oxy](1,1-dimethylethyl)dimethylsilane

1-(tert-Butyldimethylsilyloxy)-2-bromoethane

1-Bromo-2-[(tert-butyldimethylsilyl)oxy]ethane

2-bromethanolTBDMSether

(2-Bromoethoxy)dimethyl-tert-butylsilane

(2-Bromoethoxy)(1,1-dimethylethyl)dimethylsilane

(2-Bromoethoxy)dimethyl(1,1-dimethylethyl)silane

DK933

DK417

DKFELEX0249

DKSI039

(2-Bromoethoxy)(tert-butyl)dimethylsilane,98%(stabilized with NaCO3)

(2-Bromoethoxy)-|tert|-butyldimethylsilane,96%

86864-60-0

C8H19BrOS

BrCH2CH2OSiCH32CCH33

C8H19BrOSi

Oxygen Compounds

Protected Alcohols/Phenols

Organic Building Blocks

Building Blocks

Miscellaneous

Organic Building Blocks

Oxygen Compounds

Protected Alcohols/Phenols