TERT-BUTYL 4-AMINO-3-FLUOROPIPERIDINE-1-CARBOXYLATE
- Product Name
- TERT-BUTYL 4-AMINO-3-FLUOROPIPERIDINE-1-CARBOXYLATE
- CAS No.
- 934536-10-4
- Chemical Name
- TERT-BUTYL 4-AMINO-3-FLUOROPIPERIDINE-1-CARBOXYLATE
- Synonyms
- EOS-61547;4-AMino-1-Boc-3-fluoropiperidine;1-Boc-3-fluoro-4-aMinopiperidine;TERT-BUTYL 4-AMINO-3-FLUOROPIPERIDINE-1-CARBOXYLATE;1-(tert-Butyloxycarbonyl)-3-fluoro-4-aminopiperidine;1,1-Dimethylethyl 4-amino-3-fluoro-1-piperidinecarboxylate;4-amino-3-fluoro-1-Piperidinecarboxylic acid tert-butyl ester;4-AMino-3-fluoro-piperidine-1-carboxylic acid tert-butyl ester;1-Piperidinecarboxylic acid, 4-aMino-3-fluoro-, 1,1-diMethylethyl ester
- CBNumber
- CB92454178
- Molecular Formula
- C10H19FN2O2
- Formula Weight
- 218.27
- MOL File
- 934536-10-4.mol
TERT-BUTYL 4-AMINO-3-FLUOROPIPERIDINE-1-CARBOXYLATE Property
- Boiling point:
- 285.6±40.0 °C(Predicted)
- Density
- 1.11±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 8.88±0.40(Predicted)
- Appearance
- Off-white to light yellow Solid-liquid mixture
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- B694065
- Product name
- 1-(tert-Butyloxycarbonyl)-3-Fluoro-4-aminopiperidine
- Packaging
- 500mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- CS-0048229
- Product name
- tert-Butyl4-amino-3-fluoropiperidine-1-carboxylate
- Purity
- >97.0%
- Packaging
- 250mg
- Price
- $66
- Updated
- 2021/12/16
- Product number
- FB93286
- Product name
- 1-(tert-Butyloxycarbonyl)-3-fluoro-4-aminopiperidine
- Packaging
- 50mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- FB93286
- Product name
- 1-(tert-Butyloxycarbonyl)-3-fluoro-4-aminopiperidine
- Packaging
- 100mg
- Price
- $125
- Updated
- 2021/12/16
- Product number
- CS-0048229
- Product name
- tert-Butyl4-amino-3-fluoropiperidine-1-carboxylate
- Purity
- >97.0%
- Packaging
- 1g
- Price
- $126
- Updated
- 2021/12/16
TERT-BUTYL 4-AMINO-3-FLUOROPIPERIDINE-1-CARBOXYLATE Chemical Properties,Usage,Production
Uses
1-(tert-Butyloxycarbonyl)-3-Fluoro-4-aminopiperidine is a reactant in the preparation of pharmaceutical compounds which are antagonists of CGRP (Calcitonin gene-related peptide) receptors and useful in the treatment of migraine.
Synthesis
211108-50-8
934536-10-4
At room temperature, tert-butyl 3-fluoro-4-oxopiperidine-1-carboxylate (5.10 g, 23.02 mmol) was dissolved in methanol (100 mL), and ammonium acetate (12.51 g, 162.29 mmol) and sodium cyanoborohydride (1.90 g, 29.92 mmol) were added sequentially. The reaction mixture was stirred at room temperature for 18 hours. Upon completion of the reaction, the reaction was quenched with 1% aqueous sodium carbonate (50 mL). The reaction mixture was extracted with ethyl acetate (100 mL × 3) and the organic layers were combined and dried over anhydrous sodium sulfate. The organic layer was concentrated under reduced pressure to afford tert-butyl 4-amino-3-fluoropiperidine-1-carboxylate as a yellow solid (4.9 g, 98% yield).
References
[1] Patent: US2016/376283, 2016, A1. Location in patent: Paragraph 0428; 0429
[2] Patent: US2015/51209, 2015, A1
[3] Patent: WO2015/22662, 2015, A1
TERT-BUTYL 4-AMINO-3-FLUOROPIPERIDINE-1-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from TERT-BUTYL 4-AMINO-3-FLUOROPIPERIDINE-1-CARBOXYLATE manufacturers
- Product
- TERT-BUTYL 4-AMINO-3-FLUOROPIPERIDINE-1-CARBOXYLATE 934536-10-4
- Price
- US $8.88/KG
- Min. Order
- 1KG
- Purity
- 97.0%-99.0%
- Supply Ability
- 1kg-1000kg
- Release date
- 2020-03-25