(4-IODO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER

Product Name: (4-IODO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER
CAS No.: 154048-89-2
Chemical Name: (4-IODO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER
Synonyms: 3-(Boc-amino)-4-iodopyridine;N-Boc--3-AMino-4-iodopyridine;tert-butyl 4-iodopyridin-3-ylcarbaMate;N-TERT-BUTOXYCARBONYL-3-AMINO-4-IODO-PYRIDINE;1,1-DimethylethylN-(4-iodo-3-pyridinyl)carbamate;(4-IODO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER;(4-IODO-3-PYRIDINYL)-CARBAMIC ACID, 1,1-DIMETHYLETHYL ESTER;3-amino-4-iodo-2H-pyridine-1-carboxylic acid tert-butyl ester;Carbamic acid, N-(4-iodo-3-pyridinyl)-, 1,1-dimethylethyl ester
CBNumber: CB5315080
Molecular Formula: C10H13IN2O2
Formula Weight: 320.13
MOL File: 154048-89-2.mol

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(4-IODO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER Property

Melting point:: 72-76℃
Boiling point:: 313.2±27.0 °C(Predicted)
Density: 1.652±0.06 g/cm3 (20 ºC 760 Torr)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 12.15±0.70(Predicted)
Appearance: Off-white to yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

AK Scientific

Product number: Y6067
Product name: tert-Butyl(4-iodopyridin-3-yl)carbamate
Packaging: 250mg
Price: $80
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0009294
Product name: (4-IODO-3-PYRIDINYL)-CARBAMIC ACID, 1,1-DIMETHYLETHYL ESTER
Purity: 95.00%
Packaging: 1G
Price: $967.77
Updated: 2021/12/16

Ambeed

Product number: A174361
Product name: N-Boc-3-Amino-4-iodopyridine
Purity: 96%
Packaging: 100mg
Price: $10
Updated: 2021/12/16

Ambeed

Product number: A174361
Product name: N-Boc-3-Amino-4-iodopyridine
Purity: 96%
Packaging: 250mg
Price: $15
Updated: 2021/12/16

Ambeed

Product number: A174361
Product name: N-Boc-3-Amino-4-iodopyridine
Purity: 96%
Packaging: 1g
Price: $34
Updated: 2021/12/16

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(4-IODO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production

Synthesis

56700-70-0

154048-89-2

General procedure for the synthesis of tert-butyl (4-iodopyridin-3-yl)carbamate from N-tert-butoxycarbonyl-3-aminopyridine: A dry 4-necked flask was heated under argon protection and a solution of tert-butyl pyridin-3-yl-carbamate (10 g, 51.5 mmol, CAS RN 56700-70-0) in tetrahydrofuran (THF, 100 mL) was added. The reaction system was cooled to -75 °C, followed by slow dropwise addition of tert-butyllithium (1.7 M n-pentane solution, 66.6 mL, 113 mmol) over 15 min, ensuring that the reaction temperature was maintained below -60 °C. The resulting light brown suspension was stirred continuously at -75 °C for 3.75 hours. Next, a solution of iodine (28.7 g, 113 mmol) in THF (50 mL) was added dropwise over 20 min, keeping the temperature below -63 °C. The reaction mixture was continued to be stirred at -75 °C for 1.5 h before being poured into a mixture of saturated aqueous ammonium chloride (NH4Cl, 1000 mL) and ethyl acetate (EtOAc, 500 mL). The organic layer was separated, washed sequentially with 10% sodium thiosulfate (Na2S2O3, 300 mL) aqueous solution and brine (250 mL), dried over magnesium sulfate (MgSO4) and filtered. The filtrate was treated with silica gel and concentrated by evaporation. Purification was carried out using a medium pressure liquid chromatography (MPLC) system on a 120 g silica gel column by gradient elution of n-heptane: ethyl acetate (100:0 to 0:100) to give a yellow solid product (11.7 g, 71% yield). Mass spectrum (ESI): m/z = 321.1 [M + H]+.

References

[1] Patent: US2012/232051, 2012, A1. Location in patent: Page/Page column 74
[2] Patent: WO2012/117000, 2012, A1. Location in patent: Page/Page column 157; 158
[3] Patent: WO2012/87833, 2012, A1. Location in patent: Page/Page column 148-149
[4] Journal of Organic Chemistry, 2018, vol. 83, # 3, p. 1634 - 1642
[5] Heterocycles, 1999, vol. 51, # 4, p. 721 - 726

(4-IODO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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(4-IODO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER Suppliers

China 52 India 1 Switzerland 1 United States 15 Global 69

3B Pharmachem (Wuhan) International Co.,Ltd.

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View Lastest Price from (4-IODO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: N-BOC-3-AMINO-4-IODOPYRIDINE 154048-89-2
Price: US $1.60-6.60/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-19

Career Henan Chemical Co

Product: (4-IODO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER 154048-89-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-26

154048-89-2, (4-IODO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTERRelated Search:

TERT-BUTYL 4-AMINO-3-FLUOROPIPERIDINE-1-CARBOXYLATE tert-butyl (4-bromobutyl)carbamate TERT-BUTYL N-(3-THIENYL)CARBAMATE TERT-BUTYL PROPIOLATE tert-butyl 2-(chloromethyl)-1H-benzimidazole-1-carboxylate TERT-BUTYL 4-(4-FORMYL-1,3-THIAZOL-2-YL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE 7-AMINO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER tert-butyl 6-bromo-2H-pyrido[3,2-b][1,4]oxazine-4(3H)-carboxylate tert-butyl 2-oxo-8-azaspiro[4.5]decane-8-carboxylate 1-(BOC-AMINO)-2-PROPANOL 3-(BOC-AMINO)PYRIDINE (4-IODO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER 3-Amino-4-iodopyridine (3-IODO-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER (5-IODO-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER (4-IODO-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER (2-IODO-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER (6-IODO-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER

(4-IODO-3-PYRIDINYL)-CARBAMIC ACID, 1,1-DIMETHYLETHYL ESTER

(4-IODO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER

N-TERT-BUTOXYCARBONYL-3-AMINO-4-IODO-PYRIDINE

N-Boc--3-AMino-4-iodopyridine

tert-butyl 4-iodopyridin-3-ylcarbaMate

3-amino-4-iodo-2H-pyridine-1-carboxylic acid tert-butyl ester

Carbamic acid, N-(4-iodo-3-pyridinyl)-, 1,1-dimethylethyl ester

1,1-DimethylethylN-(4-iodo-3-pyridinyl)carbamate

3-(Boc-amino)-4-iodopyridine

154048-89-2