(3-IODO-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER

Product Name: (3-IODO-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER
CAS No.: 211029-67-3
Chemical Name: (3-IODO-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER
Synonyms: CAS:211029-67-3;N-Boc-4-amino-3-iodopyridine;4-(Boc-amino)-3-iodopyridine;4-(Boc-amino)-3-iodopyridine 96%;4-(Boc-amino)-3-iodopyridine, 96%;tert-butyl 3-iodopyridin-4-ylcarbaMate;TERT-BUTYL 3-IODO-4-PYRIDINYLCARBAMATE;ert-butylN-(3-iodopyridin-4-yl)carbamate;tert-butyl N-(3-iodo-4-pyridyl)carbamate;tert-Butyl-(3-iodopyridine-4-yl)carbamate
CBNumber: CB0690591
Molecular Formula: C10H13IN2O2
Formula Weight: 320.13
MOL File: 211029-67-3.mol

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(3-IODO-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER Property

Melting point:: 79-83°C
Boiling point:: 313.2±27.0 °C(Predicted)
Density: 1.652±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
form: solid
pka: 11.85±0.70(Predicted)
color: White
Sensitive: Light Sensitive
CAS DataBase Reference: 211029-67-3(CAS DataBase Reference)

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Safety

HS Code: 2924190091

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: I719553
Product name: (3-Iodo-pyridin-4-yl)-carbamicacidtert-butylester
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: I719553
Product name: (3-Iodo-pyridin-4-yl)-carbamicacidtert-butylester
Packaging: 500mg
Price: $65
Updated: 2021/12/16

Matrix Scientific

Product number: 071866
Product name: N-Boc-4-Amino-3-iodopyridine
Purity: 95+%
Packaging: 1g
Price: $80
Updated: 2021/12/16

Apolloscientific

Product number: OR913048
Product name: (3-Iodo-pyridin-4-yl)-carbamicacidtert-butylester
Purity: 98%
Packaging: 5g
Price: $113
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: COR0000254
Product name: (3-IODO-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER
Purity: 95.00%
Packaging: 250MG
Price: $136.41
Updated: 2021/12/16

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(3-IODO-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production

Synthesis

98400-69-2

211029-67-3

General procedure for the synthesis of 4-(Boc-amino)-3-iodopyridine from 4-(tert-butoxycarbonylamino)pyridine: n-butyllithium (1.6 M hexane solution, 220 ml, 0.35 mol) was added slowly and dropwise over a period of 30 min to a stirred solution of 4-(tert-butoxycarbonylamino)pyridine (26.08 g, 0.13 mol) and N,N,N' ,N'-tetramethylethylenediamine (55 ml, 0.36 mol) in a solution of tetrahydrofuran (750 ml). The reaction mixture was stirred at -78°C for 15 minutes, followed by warming to -10°C and continued stirring for 2 hours. The reaction mixture was re-cooled to -78°C and a solution of iodine (95.11 g, 0.37 mol) in tetrahydrofuran (250 ml) was added dropwise over 30 minutes. After the dropwise addition, the mixture was continued to be stirred at -78°C for 2 hours. Upon completion of the reaction, the reaction mixture was cooled to 0°C using an ice water bath and the reaction was quenched by the slow addition of water (250 ml). Saturated sodium sulfite solution (100 ml) was then added and the organic layer was separated. The aqueous layer was extracted with dichloromethane (2 x 500 ml), the organic layers were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to give a brown oil. The crude product was purified by silica gel fast column chromatography with 20% ethyl acetate/heptane as eluent to afford tert-butyl (3-iodopyridin-4-yl)-carbamate (25.00 g, 58%) as an off-white solid.1H NMR (400 MHz, CDCl3) δ 8.76 (1H, s), 8.35 (1H, d, J = 5.7 Hz), 8.11 (1H , d, J = 5.7 Hz), 7.04 (1H, br s), 1.55 (9H, s); retention time (Tr) = 0.99 min, m/z (ES+) (M+H)+ 321.08.

References

[1] Patent: WO2005/121141, 2005, A1. Location in patent: Page/Page column 13; 20
[2] Journal of Organic Chemistry, 2004, vol. 69, # 20, p. 6772 - 6780

(3-IODO-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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(3-IODO-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER Suppliers

China 80 France 1 Germany 3 India 3 United Kingdom 4 United States 24 Global 115

J & K SCIENTIFIC LTD.

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View Lastest Price from (3-IODO-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER manufacturers

Dideu Industries Group Limited

Product: (3-IODO-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER 211029-67-3
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-09-01

Zhuozhou Wenxi import and Export Co., Ltd

Product: (3-IODO-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER 211029-67-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Career Henan Chemical Co

Product: (3-IODO-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER 211029-67-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-31

211029-67-3, (3-IODO-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTERRelated Search:

(2-IODO-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER (6-IODO-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER (2-CHLORO-3-IODO-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER (4-IODO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER (4-IODO-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER (5-IODO-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER (2-CHLORO-4-IODO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER (3-IODO-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER 3-Iodo-4-aminopyridine 4-(Boc-amino)pyridine

(3-Iodopyridin-4-yl)carbamic acid 1,1-dimethylethyl ester

tert-butyl N-(3-iodopyridin-4-yl)carbamate

tert-Butyl-(3-iodopyridine-4-yl)carbamate

TERT-BUTYL 3-IODO-4-PYRIDINYLCARBAMATE

(3-IODO-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER

4-(Boc-amino)-3-iodopyridine, 96%

4-(Boc-amino)-3-iodopyridine 96%

N-Boc-4-amino-3-iodopyridine

Carbamic acid, (3-iodo-4-pyridinyl)-, 1,1-dimethylethyl ester (9CI)

tert-butyl 3-iodopyridin-4-ylcarbaMate

Carbamic acid, N-(3-iodo-4-pyridinyl)-, 1,1-dimethylethyl ester

ert-butylN-(3-iodopyridin-4-yl)carbamate

(3-IODO-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER ISO 9001：2015 REACH

4-(tert-Butoxycarbonylamino)-3-iodopyridine

tert-butyl N-(3-iodo-4-pyridyl)carbamate

CAS:211029-67-3

4-(Boc-amino)-3-iodopyridine

211029-67-3

CMLLYL

Heterocycle-Pyridine series

Pyridines