ChemicalBook > CAS DataBase List > CYCLOBARBITAL

CYCLOBARBITAL

Product Name
CYCLOBARBITAL
CAS No.
52-31-3
Chemical Name
CYCLOBARBITAL
Synonyms
Adorm;Irifan;Amnosed;Cavonyl;Hexemal;Namuron;Palinum;Rapidal;Fanodorm;Hypnoval
CBNumber
CB9491306
Molecular Formula
C12H16N2O3
Formula Weight
236.27
MOL File
52-31-3.mol
More
Less

CYCLOBARBITAL Property

Melting point:
171-174°
Boiling point:
378.73°C (rough estimate)
Density 
1.1623 (rough estimate)
refractive index 
1.5460 (estimate)
solubility 
Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
form 
Solid
pka
8.03±0.10(Predicted)
color 
White to Off-White
Water Solubility 
8.27g/L(25 ºC)
More
Less

Safety

RIDADR 
3249
HazardClass 
6.1(b)
PackingGroup 
III
Toxicity
LD50 in mice, rats (mg/kg): 350, 290 i.p. (Hofrichter)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

More
Less

CYCLOBARBITAL Chemical Properties,Usage,Production

Originator

Cyclobarbital,Bayer

Uses

Cyclobarbital has been used as an anesthetic and sedative. Controlled substance (depressant).

Definition

ChEBI: Cyclobarbital is a member of barbiturates.

Manufacturing Process

772.0 g of δ-1,2-cyclohexenylcyanacetic acid ethyl ester are introduced into astirred and ice cooled solution of 92.0 g of sodium in 1500 ml of absolutealcohol. The sodium δ-1,2-cyclohexenylcyanacetic acid ester formed is thengradually treated without ice cooling with 750.0 g of ethyl iodide. The reactionmixture become warm, sodium iodide separates out and the whole is neutralafter a short time. The sodium iodide is filtered off, the filtrate freed fromalcohol by distillation, the residues taken up in water, siphoned off, dried overcalcium chloride and distilled in vacuum, yields δ-1,2-cyclohexenylethylcyanacetic acid ethyl ester, boil point 125°C. 72.0 g ofsodium are dissolved in 1086.0 g of absolute alcohol and boiled for 3.75 hwith 285.0 g of guanidine sulfate, then 221.0 g of δ-1,2-cyclohexenylethylcyanacetic acid ester are added and boiling is continued for afurther 12 h. The residue remaining after distilling off the alcohol is boiledwith 10 times its weight of dilute sulfuric acid and then δ-1,2-cyclohexenylethylbarbituric acid which separates out is recrystallized from hotwater, melting point 170°C

brand name

Phanodorn (Sterling Winthrop).

Therapeutic Function

Hypnotic

Safety Profile

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by ingestion: pulmonary consolidation. Used as a central nervous system depressant, hypnotic, and sedative. When heated to decomposition it emits toxic fumes of NOx. See also BARBITURATES.

CYCLOBARBITAL Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

CYCLOBARBITAL Suppliers

52-31-3, CYCLOBARBITALRelated Search:


  • 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-(1-cyclohexen-1-yl)-5-ethyl-
  • 5-(1-Cyclohexen-1-yl)-5-ethyl-2,4,6(1H,3H,5H)-pyrimidinetrione
  • 5-(1-cyclohexen-1-yl)-5-ethyl-barbituricaci
  • 5-(1-Cyclohexenyl)-5-ethylbarbituric acid
  • 5-(1-cyclohexenyl)-5-ethylbarbituricacid
  • 5-Ethyl-5-cyclohexenylbarbituric acid
  • 5-ethyl-5-cyclohexenylbarbituricacid
  • Adorm
  • Amnosed
  • Barbituric acid, 5-(1-cyclohexen-1-yl)-5-ethyl-
  • Cavonyl
  • Cyclobarbitol
  • Cyclobarbiton
  • Cyclobarbitone
  • Cyclodorm
  • Cyclohexal
  • Cyclohexenyl-ethyl barbituric acid
  • 5-(1-CYCLOHEXEN-1-YL)-5-ETHYLBARBITURIC ACID
  • 5-(cyclohex-1-enyl)-5-ethylbarturic acid
  • cyclohexenyl-ethylbarbituricacid
  • Cyklodorm
  • Fanodorm
  • Fanodormo
  • Hexemal
  • Hypnoval
  • Irifan
  • Namuron
  • Palinum
  • Phanodorm
  • Phanodorn
  • Philodorm
  • Praelumin
  • Pralumin
  • Pro-Sonil
  • Sonaform
  • Sonoform
  • Tetrahydrophenobarbital
  • 5-(1-Cyclohexen-1-yl)-5-ethyl-
  • 5-(1-Cyclohexen-1-yl)-5-ethylbarbituric Acid Ethylhexabital
  • Rapidal
  • 5-cyclohexen-1-yl-5-ethyl-1,3-diazinane-2,4,6-trione
  • 5-cyclohexen-1-yl-5-ethyl-barbituric acid
  • ETHYLHEXABITAL
  • CYCLOBARBITAL
  • CYCLOBARBITAL USP/EP/BP
  • Tibolone Impurity 13
  • 52-31-3
  • Amines
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals