tert-Butyl phenyl carbonate
- Product Name
- tert-Butyl phenyl carbonate
- CAS No.
- 6627-89-0
- Chemical Name
- tert-Butyl phenyl carbonate
- Synonyms
- Einecs 229-601-8;BUTTPARK 52\11-34;t-Butyl phenyl carbonate;ert-Butyl phenyl carbonate;tart-Butylphenyl carbonate;TERT-BUTYL PHENYL CARBONATE;(2-tert-butylphenyl) carbonate;(tert-Butoxycarbonyloxy)benzene;tert-Butyl phenyl carbonate 98%;tert-Butyl Phenyl Carbonate >
- CBNumber
- CB9491922
- Molecular Formula
- C11H14O3
- Formula Weight
- 194.23
- MOL File
- 6627-89-0.mol
tert-Butyl phenyl carbonate Property
- Boiling point:
- 83 °C/0.6 mmHg (lit.)
- Density
- 1.05 g/mL at 20 °C (lit.)
- refractive index
- n20/D 1.480
- Flash point:
- 214 °F
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Chloroform (Slightly)
- form
- Liquid or Low Melting Solid
- color
- Colorless
- Water Solubility
- Slightly soluble in water.
- BRN
- 2361602
- NIST Chemistry Reference
- Carbonic acid 1,1-dimethylethyl ester(6627-89-0)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 124303
- Product name
- tert-Butyl phenyl carbonate
- Purity
- 98%
- Packaging
- 25g
- Price
- $75
- Updated
- 2025/07/31
- Product number
- 124303
- Product name
- tert-Butyl phenyl carbonate
- Purity
- 98%
- Packaging
- 100g
- Price
- $156
- Updated
- 2023/06/20
- Product number
- B3590
- Product name
- tert-Butyl Phenyl Carbonate
- Purity
- >96.0%(HPLC)
- Packaging
- 5g
- Price
- $23
- Updated
- 2025/07/31
- Product number
- B3590
- Product name
- tert-Butyl Phenyl Carbonate
- Purity
- >96.0%(HPLC)
- Packaging
- 25g
- Price
- $92
- Updated
- 2025/07/31
- Product number
- B809300
- Product name
- tert-Butyl phenyl carbonate
- Packaging
- 5g
- Price
- $110
- Updated
- 2021/12/16
tert-Butyl phenyl carbonate Chemical Properties,Usage,Production
Chemical Properties
Clear light yellow liquid
Uses
tert-Butyl phenyl carbonate is used in determination of octanol-water partition coefficients by microemulsion electrokinetic chromatography. It is also used in the synthesis of 2-nitroindoles and as a reagent for mono-Boc protection of α,ω-diamines.
Synthesis
24424-99-5
108-95-2
6627-89-0
GENERAL METHOD: Di-tert-butyl dicarbonate (Boc2O, 1.0 mmol) was added to a round-bottomed flask containing phenol (1.0 mmol) and magnesium bromide ethyl ether compound (MgBr2-OEt2, 0.1 mmol). After gas escape was observed, the reaction mixture was magnetically stirred at room temperature (heated to about 60 °C if necessary). The progress of the reaction was monitored by thin-layer chromatography (TLC) and left until the phenol was completely consumed (reaction time was usually 3-16 h). Upon completion of the reaction, the mixture was diluted with water and extracted with ethyl acetate (EtOAc, 3 x 20 mL). The organic phases were combined, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure. The residue was purified by silica gel column chromatography using a gradient elution of 5-30% ethyl acetate/hexane to afford the target product tert-butyl phenyl carbonate.
Purification Methods
If IR is free from OH, then purify it by redistillation; otherwise dissolve it in Et2O, wash it with 5% HCl, then H2O, dry it (MgSO4), evaporate and distil it through a Claisen head under vacuum. Care should be taken as distillation of large quantities can lead to decomposition with liberation of CO2 and isobutylene; use the necessary precautions. [Carpino J Am Chem Soc 79 98 1957, Beilstein 6 IV 629.]
References
[1] Green Chemistry, 2011, vol. 13, # 2, p. 436 - 443
[2] Canadian Journal of Chemistry, 1985, vol. 63, p. 153 - 162
[3] Canadian Journal of Chemistry, 1985, vol. 63, p. 153 - 162
[4] Organic Letters, 2005, vol. 7, # 3, p. 427 - 430
[5] Synlett, 2006, # 13, p. 2104 - 2108
tert-Butyl phenyl carbonate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from tert-Butyl phenyl carbonate manufacturers
- Product
- tert-Butyl phenyl carbonate 6627-89-0
- Price
- US $2.20-8.80/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 100kg
- Release date
- 2025-09-08
- Product
- tert-Butyl phenyl carbonate 6627-89-0
- Price
- US $8.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 10MT
- Release date
- 2018-12-16