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tert-Butyl phenyl carbonate

Product Name
tert-Butyl phenyl carbonate
CAS No.
6627-89-0
Chemical Name
tert-Butyl phenyl carbonate
Synonyms
Einecs 229-601-8;BUTTPARK 52\11-34;t-Butyl phenyl carbonate;ert-Butyl phenyl carbonate;tart-Butylphenyl carbonate;TERT-BUTYL PHENYL CARBONATE;(2-tert-butylphenyl) carbonate;(tert-Butoxycarbonyloxy)benzene;tert-Butyl phenyl carbonate 98%;tert-Butyl Phenyl Carbonate >
CBNumber
CB9491922
Molecular Formula
C11H14O3
Formula Weight
194.23
MOL File
6627-89-0.mol
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tert-Butyl phenyl carbonate Property

Boiling point:
83 °C/0.6 mmHg (lit.)
Density 
1.05 g/mL at 20 °C (lit.)
refractive index 
n20/D 1.480
Flash point:
214 °F
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Chloroform (Slightly)
form 
Liquid or Low Melting Solid
color 
Colorless
Water Solubility 
Slightly soluble in water.
BRN 
2361602
NIST Chemistry Reference
Carbonic acid 1,1-dimethylethyl ester(6627-89-0)
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Safety

Safety Statements 
23-24/25
WGK Germany 
3
F 
21
HS Code 
29209090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
124303
Product name
tert-Butyl phenyl carbonate
Purity
98%
Packaging
25g
Price
$75
Updated
2025/07/31
Sigma-Aldrich
Product number
124303
Product name
tert-Butyl phenyl carbonate
Purity
98%
Packaging
100g
Price
$156
Updated
2023/06/20
TCI Chemical
Product number
B3590
Product name
tert-Butyl Phenyl Carbonate
Purity
>96.0%(HPLC)
Packaging
5g
Price
$23
Updated
2025/07/31
TCI Chemical
Product number
B3590
Product name
tert-Butyl Phenyl Carbonate
Purity
>96.0%(HPLC)
Packaging
25g
Price
$92
Updated
2025/07/31
TRC
Product number
B809300
Product name
tert-Butyl phenyl carbonate
Packaging
25g
Price
$225
Updated
2021/12/16
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tert-Butyl phenyl carbonate Chemical Properties,Usage,Production

Chemical Properties

Clear light yellow liquid

Uses

tert-Butyl phenyl carbonate is used in determination of octanol-water partition coefficients by microemulsion electrokinetic chromatography. It is also used in the synthesis of 2-nitroindoles and as a reagent for mono-Boc protection of α,ω-diamines.

Synthesis

24424-99-5

108-95-2

6627-89-0

GENERAL METHOD: Di-tert-butyl dicarbonate (Boc2O, 1.0 mmol) was added to a round-bottomed flask containing phenol (1.0 mmol) and magnesium bromide ethyl ether compound (MgBr2-OEt2, 0.1 mmol). After gas escape was observed, the reaction mixture was magnetically stirred at room temperature (heated to about 60 °C if necessary). The progress of the reaction was monitored by thin-layer chromatography (TLC) and left until the phenol was completely consumed (reaction time was usually 3-16 h). Upon completion of the reaction, the mixture was diluted with water and extracted with ethyl acetate (EtOAc, 3 x 20 mL). The organic phases were combined, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure. The residue was purified by silica gel column chromatography using a gradient elution of 5-30% ethyl acetate/hexane to afford the target product tert-butyl phenyl carbonate.

Purification Methods

If IR is free from OH, then purify it by redistillation; otherwise dissolve it in Et2O, wash it with 5% HCl, then H2O, dry it (MgSO4), evaporate and distil it through a Claisen head under vacuum. Care should be taken as distillation of large quantities can lead to decomposition with liberation of CO2 and isobutylene; use the necessary precautions. [Carpino J Am Chem Soc 79 98 1957, Beilstein 6 IV 629.]

References

[1] Green Chemistry, 2011, vol. 13, # 2, p. 436 - 443
[2] Canadian Journal of Chemistry, 1985, vol. 63, p. 153 - 162
[3] Canadian Journal of Chemistry, 1985, vol. 63, p. 153 - 162
[4] Organic Letters, 2005, vol. 7, # 3, p. 427 - 430
[5] Synlett, 2006, # 13, p. 2104 - 2108

tert-Butyl phenyl carbonate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from tert-Butyl phenyl carbonate manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
tert-Butyl phenyl carbonate 6627-89-0
Price
US $2.20-8.80/kg
Min. Order
1kg
Purity
99%min
Supply Ability
100kg
Release date
2025-09-08
Career Henan Chemical Co
Product
tert-Butyl phenyl carbonate 6627-89-0
Price
US $8.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
10MT
Release date
2018-12-16

6627-89-0, tert-Butyl phenyl carbonateRelated Search:

BOC-OIC-OH tert-Butylhydrazine hydrochloride (4-TERT-BUTOXYCARBOXYPHENYL)BORONIC ACID tert-Butyl phenyl carbonate 3-(TERT-BUTOXYCARBONYL)PHENYLBORONIC ACID T -BUTYL-P-NITROPHENYL CARBONATE TERT-BUTYL PENTACHLOROPHENYL CARBONATE P-O-T-BOC-BENZYL ALCOHOL BPOC REAGENT DIBOC-6-TRIMETHYLSTANNYL-L-PHENYLALANINE ETHYL ESTER Tert-Butyl 4-Vinylphenyl Carbonate TERT-BUTYL-3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL CARBONATE CARBONIC ACID TERT-BUTYL 2,4,5-TRICHLOROPHENYL ESTER BOC-TYR(BOC)-OH P-O-T-BOC-BENZYLMETHANETHIOSULFONATE TERT-BUTYL 4-FORMYLPHENYL CARBONATE TERT-BUTYL 4-FORMYL-2-METHOXYPHENYL CARB ONATE, 99 Cholesterylp-tert.butylphenylcarbonate

  • (2-tert-butylphenyl) carbonate
  • (tert-Butoxycarbonyloxy)benzene
  • Carbonic acid O-phenyl O-tert-butyl ester
  • Carbonic acid O-tert-butyl O-phenyl ester
  • Carbonic acid tert-butylphenyl ester
  • Einecs 229-601-8
  • Carbonicacidtert-butylesterphenylester
  • ert-Butyl phenyl carbonate
  • 2-Methyl-2-propanyl phenyl carbonate
  • tert-Butyl phenyl carbonate Carbonic acid tert-butyl phenyl ester
  • Carbonic acid, 1,1-dimethylethyl phenyl ester
  • t-Butyl phenyl carbonate
  • BUTTPARK 52\11-34
  • TERT-BUTYL PHENYL CARBONATE
  • tert-Butyl phenyl carbonate 98%
  • tert-Butyl phenyl carbonate≥ 98%(HPLC)
  • tert-Butyl Phenyl Carbonate &gt
  • tart-Butylphenyl carbonate
  • Carbonic acid, 1,1-dimethylethyl phenyl ester (9CI, ACI)
  • <i>tert</i>-Butyl phenyl carbonate
  • 6627-89-0
  • CH33COCOOC6H5
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