4-AMINO-N-(2-PHENYLETHYL)BENZENESULFONAMIDE

Product Name: 4-AMINO-N-(2-PHENYLETHYL)BENZENESULFONAMIDE
CAS No.: 587850-67-7
Chemical Name: 4-AMINO-N-(2-PHENYLETHYL)BENZENESULFONAMIDE
Synonyms: CS-1909;C7280948;AKOS BBB/007;C7280948, >98%;ASISCHEM B51558;C 7280948;C-7280948;C-7280948, 10 mM in DMSO;C 7280948, PRMT1 inhibitor;4-AMINO-N-PHENETHYL-BENZENESULFONAMIDE;4-AMINO-N-(2-PHENYLETHYL)BENZENESULFONAMIDE
CBNumber: CB9493764
Molecular Formula: C14H16N2O2S
Formula Weight: 276.35
MOL File: Mol file

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4-AMINO-N-(2-PHENYLETHYL)BENZENESULFONAMIDE Property

Melting point:: 143℃
Boiling point:: 481.1±55.0 °C(Predicted)
Density: 1.258±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: insoluble in H2O; insoluble in EtOH; ≥13.9 mg/mL in DMSO
form: solid
pka: 12.47±0.50(Predicted)
color: White to off-white

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Safety

Hazard Codes: Xi
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21601
Product name: C-7280948
Purity: ≥98%
Packaging: 100mg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 21601
Product name: C-7280948
Purity: ≥98%
Packaging: 250mg
Price: $172
Updated: 2024/03/01

Cayman Chemical

Product number: 21601
Product name: C-7280948
Purity: ≥98%
Packaging: 500mg
Price: $324
Updated: 2024/03/01

Cayman Chemical

Product number: 21601
Product name: C-7280948
Purity: ≥98%
Packaging: 1g
Price: $575
Updated: 2024/03/01

ApexBio Technology

Product number: B5913
Product name: C7280948
Packaging: 10mM(in 1mL DMSO)
Price: $50
Updated: 2021/12/16

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4-AMINO-N-(2-PHENYLETHYL)BENZENESULFONAMIDE Chemical Properties,Usage,Production

Uses

C-7280948 is a selective and potent protein methyltransferase1 (PRMT1) inhibitor with an IC50 value of 12.75 μM[1].

Biological Activity

c7280948 is a novel prmt1 inhibitor with ic50 value of 12.75 μm [1].protein arginine methyltransferase 1 (prmt1) is a histone methyltransferase specific for histone h4. prmt1 catalyzes the transfer of the methyl group from sam to the guanidine nitrogen atoms of arginine residues to produce monomethyl arginines (mma) and asymmetric dimethyl arginines (adma) [2].c7280948 is a novel prmt1 inhibitor. c7280948 interacts with aromatic residues at the hprmt1 substrate binding pocket (tyr 147 and tyr 160) [1]. c7280948 inhibited hprmt1 with ic50 value of 26.7 μm [3].

Synthesis

52374-24-0

587850-67-7

General procedure for the synthesis of 4-amino-N-phenethylbenzenesulfonamide from 4-nitro-N-phenethylbenzenesulfonamide: Concentrated hydrochloric acid (10-15 mL) was slowly added to a mixture of ethanol (10 mL) containing 4-nitro-N-phenethylbenzenesulfonamide or its analog (13a-q, 1.4 mmol, 1 equiv.) and tin particles (2-2.5 equiv.). The reaction mixture was refluxed for 3.5-6 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) until the feedstock completely disappeared. Upon completion of the reaction, the mixture was cooled to room temperature. Subsequently, 30% or 5 M aqueous sodium hydroxide solution was slowly added to the mixture until the reaction mixture became alkaline. The mixture was extracted with ethyl acetate (EA) or dichloromethane (DCM) and the organic layer was dried with anhydrous sodium sulfate (Na2SO4). The solvent was removed by evaporation under reduced pressure. If necessary, the product was purified by column chromatography. Using 13j (0.37 g, 1.2 mmol) as raw material, 4-amino-N-phenylethylbenzenesulfonamide (14j) was obtained as a yellow solid (0.39 g, 100% yield), which was ready to be used without further purification, according to the above described General Procedure B. The 1H NMR (DMSO-d6) data were as follows: δ 2.64 (2H, t, J = 7.7 Hz), δ 2.85 (2H, dt, J = 7.7, 5.8 Hz), 5.92 (2H, s), 6.60 (2H, d, J = 8.6 Hz), 7.12 (2H, d, J = 8.2 Hz), 7.20 (1H, t, J = 6.3 Hz), 7.26 (2H, t, J = 7.6 Hz), 7.40 (2H, d, J = 8.6 Hz).

IC 50

PRMT1

References

[1]. heinke r, spannhoff a, meier r, et al. virtual screening and biological characterization of novel histone arginine methyltransferase prmt1 inhibitors. chemmedchem, 2009, 4(1): 69-77.
[2]. itoh y, suzuki t, miyata n. small-molecular modulators of cancer-associated epigenetic mechanisms. mol biosyst, 2013, 9(5): 873-896.
[3]. bissinger em, heinke r, spannhoff a, et al. acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methyltransferase hprmt1. bioorg med chem, 2011, 19(12): 3717-3731.

4-AMINO-N-(2-PHENYLETHYL)BENZENESULFONAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-AMINO-N-(2-PHENYLETHYL)BENZENESULFONAMIDE Suppliers

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View Lastest Price from 4-AMINO-N-(2-PHENYLETHYL)BENZENESULFONAMIDE manufacturers

Career Henan Chemical Co

Product: 4-AMINO-N-(2-PHENYLETHYL)BENZENESULFONAMIDE 587850-67-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%~99%
Supply Ability: per week:100kg
Release date: 2019-09-05

587850-67-7, 4-AMINO-N-(2-PHENYLETHYL)BENZENESULFONAMIDERelated Search:

C7280948, >98%

CS-1909

C 7280948;C-7280948

C7280948

ASISCHEM B51558

4-AMINO-N-PHENETHYL-BENZENESULFONAMIDE

4-AMINO-N-(2-PHENYLETHYL)BENZENESULFONAMIDE

AKOS BBB/007

4-Amino-N-(2-phenylethyl)benzenesulfonamide C 7280948

Benzenesulfonamide, 4-amino-N-(2-phenylethyl)-

C 7280948, PRMT1 inhibitor

C-7280948, 10 mM in DMSO

587850-67-7

Inhibitors