B-HT 933 DIHYDROCHLORIDE

Product Name: B-HT 933 DIHYDROCHLORIDE
CAS No.: 36067-72-8
Chemical Name: B-HT 933 DIHYDROCHLORIDE
Synonyms: b-ht933;Nsc310831;Azepexole hydrochloride;B-HT 933 (hydrochloride);Azepexole dihydrochloride;β2AR/M3-receptor agonist-1;B-HT 933 DIHYDROCHLORIDE SELECTIVE A2 AD RENORE;5-d)azepin-2-amine,5,6,7,8-tetrahydro-6-ethyl-4h-oxazolo(dihydrochloride;5,6,7,8-tetrahydro-6-ethyl-4h-oxazolo(4,5-d)azepin-2-aminedihydrochloride;2-amino-6-ethyl-4,5,7,8-tetrahydro-6h-oxazolo(5,4-d)azepinedihydrochloride
CBNumber: CB9496972
Molecular Formula: C9H16ClN3O
Formula Weight: 217.7
MOL File: 36067-72-8.mol

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B-HT 933 DIHYDROCHLORIDE Property

storage temp.: Desiccate at RT
solubility: H₂O: >20 mg/mL
form: solid
color: white to off-white

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Safety

WGK Germany: 2
RTECS: RQ5831345

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 11941
Product name: B-HT 933 (hydrochloride)
Purity: ≥95%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 11941
Product name: B-HT 933 (hydrochloride)
Purity: ≥95%
Packaging: 5mg
Price: $139
Updated: 2024/03/01

Cayman Chemical

Product number: 11941
Product name: B-HT 933 (hydrochloride)
Purity: ≥95%
Packaging: 10mg
Price: $199
Updated: 2024/03/01

Cayman Chemical

Product number: 11941
Product name: B-HT 933 (hydrochloride)
Purity: ≥95%
Packaging: 25mg
Price: $456
Updated: 2024/03/01

TRC

Product number: H671813
Product name: B-HT933Dihydrochloride
Packaging: 25mg
Price: $215
Updated: 2021/12/16

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B-HT 933 DIHYDROCHLORIDE Chemical Properties,Usage,Production

Description

B-HT 933 is an agonist of α₂-adrenergic receptors (α₂-ARs) with an EC₅₀ value of 0.65 μM for contraction of canine sapheneous veins. It induces concentration-dependent inhibition of the twitch response in rat vas deferens and guinea pig ileum. B-HT 933 induces sedation and reduces motor activity in mice, an effect that is reversed by the α₂-AR antagonist yohimbine . B-HT 933 decreases blood pressure and cardiac output in cats injected with 30 μg/kg intracisternally. It also exhibits antinociceptive effects in mice with ED₅₀ values of 12.5, 20.5, and 6.1 mg/kg for the tail-immersion, tail-pinch, and acetic acid writhing tests, respectively.

Uses

B-HT 933 Dihydrochloride is a selective α2-adrenoceptor agonist and has less potent inhibitory effect on the sympathetic vasopressor responses in diabetic rats.

in vitro

b-ht 933, a selective α2-adrenoceptor agonist, contracts human subcutaneous resistance arteries by a mechanism largely dependent on the influx of extracellular ca2+, probably through voltage-operated calcium channels. this action involves a pertussis toxin-sensitive g protein, possibly gq [1].

in vivo

the dose-related effects of the selective α2-adrenoceptor agonist b-ht 933 on the body temperature of untreated and reserpine-treated mice were investigated. in untreated mice b-ht 933 induced a dose-related hypothermia. the highest dose of b-ht 933 elicited a marked hypothermia, whereas the maximal hypothermic effect of clonidine was less pronounced and reached a plateau at a dose of 0.5 mg/kg [2].

IC 50

0.44 μm

storage

Desiccate at RT

References

[1] n. a. parkinson & a.d. hughes. the mechanism of action of 1c2-adrenoceptors in human isolated subcutaneous resistance arteries. british journal of pharmacology (1995) 115, 1463-1468
[2] d. j. bill, i.e. hughes & r.j. stephens. the thermogenic actions of x2-adrenoceptor agonists in reserpinized mice are mediated via a central postsynaptic ac2-adrenoceptor mechanism. br. j. pharmacol. (1989), 96, 133-143

B-HT 933 DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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B-HT 933 DIHYDROCHLORIDE Suppliers

China 14 India 1 South Korea 1 Switzerland 1 United Kingdom 1 United States 5 Global 23

3B Pharmachem (Wuhan) International Co.,Ltd.

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Energy Chemical

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Nantong QuanYi Biotechnology Co., Ltd

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RD International Technology Co., Limited

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Beijing Hassanal Technology Limited Liability Company

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36067-72-8, B-HT 933 DIHYDROCHLORIDERelated Search:

Azepexole 4,5-dimethyloxazol-2-amine B-HT 933 DIHYDROCHLORIDE 5-METHYL-OXAZOL-2-YLAMINE 2-AMINO-4-METHYLOXAZOLE

2-amino-6-ethyl-4,5,7,8-tetrahydro-6h-oxazolo(5,4-d)azepinedihydrochloride

5,6,7,8-tetrahydro-6-ethyl-4h-oxazolo(4,5-d)azepin-2-aminedihydrochloride

5-d)azepin-2-amine,5,6,7,8-tetrahydro-6-ethyl-4h-oxazolo(dihydrochloride

b-ht933

B-HT 933 DIHYDROCHLORIDE SELECTIVE A2 AD RENORE

Azepexole dihydrochloride, 6-Ethyl-5,6,7,8-tetrahydro-4H-oxazolo[4,5-d]azepin-2-amine dihydrochloride

Azepexole hydrochloride

Nsc310831

Azepexole dihydrochloride

B-HT 933 (hydrochloride)

β2AR/M3-receptor agonist-1

36067-72-8

C9H15N3O2HCl